Fuzhuan tea consumption imparts hepatoprotective effects and alters intestinal microbiota in high saturated fat diet‐fed rats

Foster, Michelle T.; Gentile, Christopher L.; Cox-York, Kimberly; Wei, Yu; Wang, Dong; Estrada, Andrea; Reese, Lauren; Miller, Tirrel; Pagliassotti, Michael J.; Weir, Tiffany L.

doi:10.1002/mnfr.201500654

Cited by 62 publications

(55 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that the relative abundance of Lactobacillus spp. showed a threefold increase due to FBT intervention in high saturated fat diet‐fed rats . However, the increase in the relative abundance of Lactobacillus spp.…”

Section: Discussionmentioning

confidence: 98%

“…Furthermore, Lactobacillus johnsonii and another Lactobacillus sp. in high saturated fat diet‐fed rats could be enhanced by FBT intake . However, the potential role of gut microbiota modulated by KDC and FBT in the prevention of obesity is still not clearly understood.…”

Section: Discussionmentioning

confidence: 99%

“…For example, black, Oolong, and green teas could alter the structure of gut microbiota in high‐fat‐diet (HFD) fed mice, including Parabacteroides , Allobaculum , Bacteroides , Akkermansia , Lachnospiraceae , Alistipes , and Rikenella . Likewise, FBT could also alter gut microbiota in HFD‐induced rats with a threefold increase in two Lactobacillus spp . However, the potential role of gut microbiota modulated by FBT in the prevention of obesity is still not clearly understood.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Kudingcha and Fuzhuan Brick Tea Prevent Obesity and Modulate Gut Microbiota in High‐Fat Diet Fed Mice

Chen

Xie

Dai

et al. 2018

Molecular Nutrition Food Res

181

136

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Kudingcha and Fuzhuan Brick Tea Prevent Obesity and Modulate Gut Microbiota in High‐Fat Diet Fed Mice

Chen

Xie

Dai

et al. 2018

Molecular Nutrition Food Res

181

136

View full text Add to dashboard Cite

show abstract

“…In addition, tea has exhibited the neuro-protective effect, in terms of protecting against age-related neuro-degenerative disorders, depression and regulating the circadian clock [184][185][186][187][188][189][190]. Moreover, tea could inhibit gastric ulcer and improve gastrointestinal function [191][192][193][194][195]. Besides, tea could modulate gut microbiota composition (increase beneficial microorganisms and decrease harmful microorganisms), which might be beneficial to those in the risk of obesity, metabolic syndrome, hyperlipidemia, and cardiovascular diseases [196][197][198][199][200][201][202].…”

Section: Other Health Functionsmentioning

confidence: 99%

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

Tang

Meng

Gan

et al. 2019

IJMS

270

150

View full text Add to dashboard Cite

Tea is widely consumed all over the world. Generally, tea is divided into six categories: White, green, yellow, oolong, black, and dark teas, based on the fermentation degree. Tea contains abundant phytochemicals, such as polyphenols, pigments, polysaccharides, alkaloids, free amino acids, and saponins. However, the bioavailability of tea phytochemicals is relatively low. Thus, some novel technologies like nanotechnology have been developed to improve the bioavailability of tea bioactive components and consequently enhance the bioactivity. So far, many studies have demonstrated that tea shows various health functions, such as antioxidant, anti-inflammatory, immuno-regulatory, anticancer, cardiovascular-protective, anti-diabetic, anti-obesity, and hepato-protective effects. Moreover, it is also considered that drinking tea is safe to humans, since reports about the severe adverse effects of tea consumption are rare. In order to provide a better understanding of tea and its health potential, this review summarizes and discusses recent literature on the bioactive components, bioavailability, health functions, and safety issues of tea, with special attention paid to the related molecular mechanisms of tea health functions.

show abstract

“…Fuzhuan brick tea (FBT, also named Fu brick tea) is a fermented tea in the presence of a dominant fungi species named Eurotium cristatum, which is yellow-colored and is thus also called "golden flora" (" 金花") in Chinese 23 . Human consumption of FBT dated back to the 16 th century 24 , while recent pilot dietary interventions on humans in China have also shown that FBT consumption could improve metabolic disease conditions, which were summarized in Supplementary Table 1. FBT consumption or polysaccharides extracted from FBT were shown to reduce obesity, hyperlipidemia and arterial stiffening, as well as to improve metabolic syndrome in animals [25][26][27][28] . The water or ethanol extracts of FBT reduced obesity through normalizing gut microbiota in mice 25,29 .…”

Section: Introductionmentioning

confidence: 99%

Eurotium cristatum, a new fungi probiotic from Fuzhuan brick tea, alleviated obesity in mice by modulating gut microbiota

Kang

Duan

et al. 2019

Preprint

View full text Add to dashboard Cite

Obesity is one of the major public health problems worldwide, mainly resulting from unhealthy lifestyles and diet. Gut microbiota dysbiosis may also lead to obese humans and animals. Modulating gut bacteria through fecal transplantation, the use of probiotics or certain dietary supplements, could normalize gut microbiota and subsequently alleviate obesity. Daily consumption of Fuzhuan brick tea (FBT) or its extracts have been observed to alleviate obesity in humans and experimental animals. In this study, high-fat diet-induced dysbiosis of gut microbiota in C57BL/6J mice was partially reversed by consumption of Eurotium cristatum, the dominant fungi during the manufacturing and storage of FBT. E. cristatum was able to modulate both gut fungi and bacteria composition, based on the analysis of microbiota composition of mice fecal samples. E. cristatum increased acetate and butyrate-producing bacteria in mice gut, and produced five times more butyrate than both obese and normal mice. Our results suggested that E. cristatum may be used as a fungi probiotic to beneficially modulate gut microbiota and to alleviate obesity in humans. ResultsE. cristatum may survive in mouse intestine. In order to clarify if E. cristatum could survive during tea brewing and consumption, 10 4 spores of E. cristatum isolated from FBT, were heated in water containing 20% (v/v) glycerol at 50, 70, 80, 85, 90 and 100 °С for 2, 5 or 10 min, respectively (Supplemental Fig.1). E. cristatum survived even after 10 min in 90 °С and 2 min in 100 °С. E. cristatum was next mixed with drinking water and fed to Kunming mice. E. cristatum could be isolated from mouse feces, even without feeding of E. cristatum for two weeks (Supplemental Fig. 2). There were no significant differences in body weight among mice fed with or without E. cristatum, as well as mice fed with the water extracts or filtered water extracts of Fuzhuan brick tea. These results suggested that E. cristatum from Fuzhuan brick tea is non-toxic and could survive in mice intestine. E. cristatum reduced HFD-induced obesity in C57BL/6J mice. The HFD-induced C57BL/6J obese mouse model was used to explore if live E. cristatum may have any antiobesity effect, in comparison to mice that received normal chow diet (NCD). The high-fat diet mice that received FBT or filtered Fuzhuan brick tea (FFBT), in which live E. cristatum were removed by filtering the FBT extracts using a 0.22 µm filter, were also used as controls ( Fig. 1a-e). The mice in HFD group showed significant increases in body and liver weights, and epididymal fat accumulation, compared with mice in the NCD group ( Fig. 1ae). In contrast, the high-fat diet mice that received E. cristatum (10 3 CFU/day) in drinking water showed significantly decreased body weight gain, liver weight and epididymal fat accumulation. The FFBT-treated mice also showed significant decrease in liver and

show abstract

Fuzhuan tea consumption imparts hepatoprotective effects and alters intestinal microbiota in high saturated fat diet‐fed rats

Abstract: These data suggest that Fuzhuan tea protects against liver and adipose tissue stress induced by a high SAT diet and positively influences intestinal function. Further investigation of the molecular targets of Fuzhuan tea is warranted.

Cited by 62 publications

References 36 publications

Kudingcha and Fuzhuan Brick Tea Prevent Obesity and Modulate Gut Microbiota in High‐Fat Diet Fed Mice

Kudingcha and Fuzhuan Brick Tea Prevent Obesity and Modulate Gut Microbiota in High‐Fat Diet Fed Mice

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

Eurotium cristatum, a new fungi probiotic from Fuzhuan brick tea, alleviated obesity in mice by modulating gut microbiota

Contact Info

Product

Resources

About