The prediction of performance measures is an essential one for manufacturers to increase the service life. This paper deals with the application of Artificial Intelligence (AI) to predict the performance measures like surface roughness, material removal rate, and flank wear during the milling process from the experimental data. The milling experiments were conducted in wet conditions based on the Response Surface Methodology (RSM) design of experiments. The spindle speed, feed rate, and axial depth of cut were considered as process parameters. The experimental data were used to develop the regression model, Mamdani fuzzy inference system, Backpropagation Neural Network (BPNN), and Adaptive Neuro-Fuzzy Inference System (ANFIS) model. The output of regression, fuzzy, neural network, and ANFIS model was compared with the experimental data, and predicted results were found to be in good conformity with the measured data. The prediction capability of the quadratic and Artificial Neural Network (ANN) model was very close to experimentally measured values and the quadratic model had an accuracy of 97.89% for surface roughness, 98.38% for material removal rate (MRR), and 95.72% for flank wear.