In this paper, we investigate the invertibility of generalized g-Bessel multipliers. We show that for semi-normalized symbols, the inverse of any invertible generalized g-frame multiplier can be represented as a generalized g-frame multiplier. Also we give several approaches for constructing invertible generalized g-frame multipliers from the given one. It is worth mentioning that some of our results are quite different from those studied in the previous literatures on this topic. 2010 MSC : 42C15, 47A05, 41A58.