G-protein coupled estrogen receptor (GPER) inhibits final oocyte maturation in common carp, Cyprinus carpio

Majumder, Suravi; Das, Saswati; Moulik, Sujata Roy; Mallick, B.; Pal, Puja; Mukherjee, Dilip

doi:10.1016/j.ygcen.2014.11.011

Cited by 43 publications

(28 citation statements)

References 43 publications

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“…This led to its renaming as G protein coupled estrogen receptor (GPER). Homologous GPER have since also been identified in teleosts (Atlantic croaker: Pang et al, 2008;zebrafish: Liu et al, 2009;Pang and Thomas, 2009; common carp, Cyprinus carpio: Majumder et al, 2015). While in genome databases two GPER genes have been recently annotated in some teleosts species, to our knowledge, this study in the European eel constitutes the first investigation of two GPER in teleosts, and in vertebrates.…”

Section: Introductionmentioning

confidence: 83%

Three nuclear and two membrane estrogen receptors in basal teleosts, Anguilla sp.: Identification, evolutionary history and differential expression regulation

Lafont

Rousseau

Tomkiewicz

et al. 2016

General and Comparative Endocrinology

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Section: Introductionmentioning

confidence: 83%

Three nuclear and two membrane estrogen receptors in basal teleosts, Anguilla sp.: Identification, evolutionary history and differential expression regulation

Lafont

Rousseau

Tomkiewicz

et al. 2016

General and Comparative Endocrinology

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“…In carp and zebrafish ovaries, gper mRNA was detected in pre-vitellogenic, latevitellogenic and post-vitellogenic oocytes but was not detected in ovarian follicle cells [27,34]. Thus, gper expression in teleost ovaries is consistent with a cell-autonomous role in oocyte maturation.…”

Section: Introductionmentioning

confidence: 85%

G protein-coupled estrogen receptor is not required for sex determination or ovary function in zebrafish

Crowder

Romano

Gorelick

2018

Preprint

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Estrogens regulate vertebrate development and function through binding to nuclear estrogen receptors alpha and beta (ERa, ERb) and the G protein-coupled estrogen receptor (GPER). Studies in mutant animal models demonstrated that ERa and ERb are required for normal ovary development and function. However, the degree to which GPER signaling contributes to ovary development and function is less well understood. Previous studies using cultured fish oocytes found that estradiol inhibits oocyte maturation in a GPER-dependent manner, but whether GPER regulates oocyte maturation in vivo is not known. To test the hypothesis that GPER regulates oocyte maturation in vivo, we assayed ovary development and function in gper mutant zebrafish. We found that homozygous mutant gper embryos developed into male and female adults with normal sex ratios and fertility. Adult mutant fish exhibited normal secondary sex characteristics and fertility. Additionally, mutant ovaries were histologically normal. We observed no differences in the number of immature versus mature oocytes in mutant versus wild-type ovaries from both young and aged adults.Furthermore, expression of genes associated with sex determination and ovary function were normal in gper mutant ovaries compared to wild type. Our findings suggest that GPER is not required for sex determination, ovary development or fertility in zebrafish.

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“…Furthermore, results from TEM and Hoechst 33342 staining suggested that AgNPs induced apoptosis of ovarian follicle cells. Previous studies in zebrafish and carp ( Cyprinus carpio ) have shown that removal of ovarian follicle layer led to a striking increase in spontaneous GVBD (Pang and Thomas, 2010; Majumder et al, 2015). In teleost, the inhibitory influence of ovarian follicle cells on GVBD is mediated, at least partly, through increases in cAMP concentrations via estrogen produced by the ovarian follicle cells (Pang et al, 2008; Pang and Thomas, 2010; Majumder et al, 2015).…”

Section: Discussionmentioning

confidence: 97%

“…Previous studies in zebrafish and carp ( Cyprinus carpio ) have shown that removal of ovarian follicle layer led to a striking increase in spontaneous GVBD (Pang and Thomas, 2010; Majumder et al, 2015). In teleost, the inhibitory influence of ovarian follicle cells on GVBD is mediated, at least partly, through increases in cAMP concentrations via estrogen produced by the ovarian follicle cells (Pang et al, 2008; Pang and Thomas, 2010; Majumder et al, 2015). It is possible that apoptosis of the ovarian follicle cells induced by the AgNPs resulted in termination of the transfer of cAMP from the follicle cells to the oocyte and production of estrogen, both of which result in a decrease of cAMP concentration in the oocyte that triggered the resumption of meiosis.…”

Section: Discussionmentioning

confidence: 97%

Silver nanoparticles induce oocyte maturation in zebrafish (Danio rerio)

et al. 2017

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Public concern regarding silver nanoparticles (AgNPs) in the environment has been increasing since they can cause adverse effects in some aquatic species. However, few data are actually available on the effects of AgNPs on the germ cells. In the present study, we used the zebrafish ovarian follicle as a model to assess the potentially adverse effects of AgNPs on oocyte maturation (germinal vesicle breakdown, GVBD) in vitro. Similar to the maturation inducing hormone (17α, 20β-dihydroxy-4-pregnen-3-one), AgNPs induced GVBD, and reduced the total cyclic adenosine monophosphate (cAMP) concentration in zebrafish ovarian follicles. The results from transmission electron microscope observation and Hoechst 33342 staining clearly indicated that AgNPs induced apoptosis in ovarian follicle cells surrounding the oocyte. Similar to AgNPs, AgNO3 also induced GVBD, decreased cAMP concentration and induced apoptosis of ovarian follicle cells. However, the results from gene expression analysis showed that transcript levels of oxidative stress related genes were more sensitive to AgNPs than AgNO3. Further more, H2O2 has an ability to induce zebrafish oocytes maturation by induction of apoptosis in ovarian follicle cells. Taken together, the results from our study indicated that oxidative stress appeared to be one of important mechanisms in AgNP induced apoptosis in ovarian follicle cells, which further triggered the GVBD.

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G-protein coupled estrogen receptor (GPER) inhibits final oocyte maturation in common carp, Cyprinus carpio

Cited by 43 publications

References 43 publications

Three nuclear and two membrane estrogen receptors in basal teleosts, Anguilla sp.: Identification, evolutionary history and differential expression regulation

Three nuclear and two membrane estrogen receptors in basal teleosts, Anguilla sp.: Identification, evolutionary history and differential expression regulation

G protein-coupled estrogen receptor is not required for sex determination or ovary function in zebrafish

Silver nanoparticles induce oocyte maturation in zebrafish (Danio rerio)

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