British Inherited Metabolic Disease Group and British Paediatric Neurology Association 2017
DOI: 10.1136/archdischild-2017-313087.383
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G390(P) Evaluation of the magnitude, determinants and impact of treatment lag in west syndrome

Abstract: AimsWest Syndrome is an age dependent epileptic encephalopathy with variable therapeutic response. Worldwide, there is scarce data on magnitude and effect of treatment lag on therapeutic response with adrenocorticotrophic hormone (ACTH) or steroid therapy in West Syndrome. There is conflicting evidence regarding impact of treatment lag in West Syndrome. The present study aimed to elucidate magnitude of diagnostic and treatment lag, potential determinants of treatment lag and its impact on short-term therapeuti… Show more

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“…16 Pre-existing developmental delay of children, educational status of the parents and qualification of the first practitioner visited are important determinants of treatment lag. 19,20 In the present study, treatment response was poor in both groups. The efficacy of ACTH was 40% at 6 weeks of initiation of therapy.…”
Section: Discussioncontrasting
confidence: 44%
“…16 Pre-existing developmental delay of children, educational status of the parents and qualification of the first practitioner visited are important determinants of treatment lag. 19,20 In the present study, treatment response was poor in both groups. The efficacy of ACTH was 40% at 6 weeks of initiation of therapy.…”
Section: Discussioncontrasting
confidence: 44%
“…Furthermore, the study showed shorter treatment lag (<1 month) was associated with a better spasms cessation rate (85% vs. 15%; p = 0.011). 32 In a meta-analysis of seven studies–five from India, one from Sri Lanka and Pakistan, the pooled estimate of treatment lag was 2.4 months (CI: 2.1–2.6 months). 24 …”
Section: Treatment Lag In South Asiamentioning
confidence: 99%