G801A Polymorphism of Human Stromal Cell-Derived Factor 1 Gene Raises No Susceptibility to Neoplastic Lesions of Uterine Cervix

Tee, Yi Torng; Yang, Shun Fa; Wang, Po Hui; Tsai, Hsiu Ting; Lin, Long Yau; Lee, Shu Kuei; Liao, Chiung Ling; Chang, Jinghau Tsai; Shih, Yang Tse

doi:10.1097/igc.0b013e318265d334

Cited by 9 publications

(8 citation statements)

References 26 publications

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“…In the present study, the SDF1-3' G801A SNP was not identified as a risk factor for cervical cancer. The present observations are in agreement with those by Maley et al (23) and Tee et al (24), which also observed no association between the SDF1-3' G801A polymorphism and risk of cervical cancer. However, in the present study, the P-value assessment of the trend observed for the SDF1-3' G801A polymorphism was on the borderline of statistical significance.…”

Section: Discussionsupporting

confidence: 83%

“…The possible role of the SDF1-3' A variant in the increased levels of transcription and protein has been reported (22). Certain studies have demonstrated no association between the SDF1-3' G801A single nucleotide polymorphism (SNP) and cervical carcinoma (23,24), however, the interaction between the SDF1-3' G801A SNP with other known risk factors of cervical cancer remain to be fully elucidated. In the present study, the SDF1-3' G801A genotype and allele frequencies were investigated in patients with cervical cancer (n=462) and healthy controls (n=497) in the Polish population, stratified based on contraceptive use, menopausal status, parity and history of tobacco smoking.…”

Section: Introductionmentioning

confidence: 99%

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Stromal cell-derived factor-1 G801A polymorphism and the risk factors for cervical cancer

Roszak¹,

Misztal²,

Sowińska³

et al. 2015

Molecular Medicine Reports

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Stromal cell-derived factor-1 G801A polymorphism and the risk factors for cervical cancer

Roszak¹,

Misztal²,

Sowińska³

et al. 2015

Molecular Medicine Reports

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“…A higher frequency of HPV was observed among allele A carriers, confirmed by binary logistic regression model adjusted for several factors as confounders, demonstrating that CXCL12 rs1801157 is independently associated to HPV infection. Some studies observed that the polymorphism was not a risk factor for cervical cancer development [ 13 , 14 , 27 ] however, none of them have evaluated whether the polymorphism could represent a risk factor for HPV infection as demonstrated in this study.…”

Section: Discussionmentioning

confidence: 78%

Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study

et al. 2018

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BackgroundHuman papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelial lesions (LSIL/HSIL). Immunological system plays an important role in the resolution of infections. In this context, we highlight the chemokines, which are important regulators in the development of viral infections and inflammation. Among which CXCL12 stands out, due to its pro-inflammatory features, acting as chemoattractant recruiting immune cells. Several polymorphisms were identified in CXCL12 gene including rs1801157 in the 3′-untranslated region, which is characterized by a substitution of a guanine for an adenine.MethodsIn this study, 195 women were classified as HPV non-infected and 169 as HPV-infected. HPV-DNA was detected by polymerase chain reaction (PCR) and the polymorphism was assessed in blood cells through restriction fragment length polymorphism analysis.ResultsHPV infection was more incident in women who had more than 4 sexual partners during lifetime (p = 0.007), among those who presented lower number of pregnancies (p = 0.017). HPV was more prevalent among allele A carriers confirmed by logistic regression analysis adjusted for several confounding factors [ORADJ = 4.985; CI95% (2.85–8.72), p < 0.001]. An association between allele A carriers and HSIL development (p = 0.003) was also observed.ConclusionsIn the present study, we demonstrated that CXCL12 rs1801157 is independently associated with HPV infection and exerts influence in HSIL development, suggesting it as a promising susceptibility biomarker for HPV infection and lesions development.

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“…These researches involved 36 case-control studies, 4932 cancer cases and 7917 healthy controls, and assessed the association between CXCL12 G801A polymorphism and cancer risk [10,[12][13][14] . Among the 29 eligible papers, 7 of them enrolled Asian subjects [10, [28][29][30][31][32][33] and 22 examined Caucasian ones [12][13][14][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52] (table 1). In all studies, cancer cases were diagnosed histologically or pathologically and blood samples were used for genotyping.…”

Section: Characteristics Of Eligible Studiesmentioning

confidence: 99%

CXCL12 G801A polymorphism and cancer risk: An updated meta-analysis

Meng

Heerah

et al. 2015

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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Many studies have reported the relationship between CXCL12 G801A polymorphism and cancer risk, with conflicting results. In this study, we tried to clarify the possibility that this polymorphism may increase cancer risk by conducting an updated meta-analysis. PubMed and EMbase were searched for case-control studies regarding the association of the gene polymorphism and cancer risk. Data were extracted and odds ratios (ORs) with 95% confidence intervals (95% CIs) were used to assess the strength of the association. Heterogeneity among articles and publication bias was also assessed. Significantly increased risk for cancer was found (A vs. G: OR=1.26, 95% CI=1.13-1.40, P<0.01; AA+AG vs. GG: OR=1.33, 95% CI=1.16-1.52, P<0.01). In subgroup analysis, statistically elevated cancer risk was found in both Asian and Caucasian populations (for Asian, AA+AG vs. GG: OR=1.74, 95% CI=1.22-2.47, P<0.01; for Caucasian, AA+AG vs. GG: OR=1.24, 95% CI=1.09-1.42, P<0.01). Our result indicated that CXCL12 G801A polymorphism is a risk factor for cancer. To validate the finding, further large-size case-control studies are warranted.

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G801A Polymorphism of Human Stromal Cell-Derived Factor 1 Gene Raises No Susceptibility to Neoplastic Lesions of Uterine Cervix

Abstract: Although the expression of SDF-1 was reported to be significantly increased in cervical carcinogenesis in previous studies, our results, however, show that SDF-1 gene polymorphism could not be considered as a factor related to an increased susceptibility to cervical neoplasia.

Cited by 9 publications

References 26 publications

Stromal cell-derived factor-1 G801A polymorphism and the risk factors for cervical cancer

Stromal cell-derived factor-1 G801A polymorphism and the risk factors for cervical cancer

Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study

CXCL12 G801A polymorphism and cancer risk: An updated meta-analysis

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