Stromal cell-derived factor-1 G801A polymorphism and the risk factors for cervical cancer

Roszak, A.; Misztal, Matthew; Sowińska, Anna; Jagodzińśki, Paweł P.

doi:10.3892/mmr.2015.3315

Cited by 3 publications

(3 citation statements)

References 36 publications

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“…A higher frequency of HPV was observed among allele A carriers, confirmed by binary logistic regression model adjusted for several factors as confounders, demonstrating that CXCL12 rs1801157 is independently associated to HPV infection. Some studies observed that the polymorphism was not a risk factor for cervical cancer development [ 13 , 14 , 27 ] however, none of them have evaluated whether the polymorphism could represent a risk factor for HPV infection as demonstrated in this study.…”

Section: Discussionmentioning

confidence: 78%

“…In a case-control study the rs1801157 polymorphism was not associated with invasive squamous carcinoma and adenocarcinoma in situ [ 13 ]. On the other hand, analysis between this polymorphism genotype distribution and cervical cancer risk, showed that allele A of this polymorphism may be a risk factor for patients with a positive history of tobacco smoking [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study

et al. 2018

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BackgroundHuman papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelial lesions (LSIL/HSIL). Immunological system plays an important role in the resolution of infections. In this context, we highlight the chemokines, which are important regulators in the development of viral infections and inflammation. Among which CXCL12 stands out, due to its pro-inflammatory features, acting as chemoattractant recruiting immune cells. Several polymorphisms were identified in CXCL12 gene including rs1801157 in the 3′-untranslated region, which is characterized by a substitution of a guanine for an adenine.MethodsIn this study, 195 women were classified as HPV non-infected and 169 as HPV-infected. HPV-DNA was detected by polymerase chain reaction (PCR) and the polymorphism was assessed in blood cells through restriction fragment length polymorphism analysis.ResultsHPV infection was more incident in women who had more than 4 sexual partners during lifetime (p = 0.007), among those who presented lower number of pregnancies (p = 0.017). HPV was more prevalent among allele A carriers confirmed by logistic regression analysis adjusted for several confounding factors [ORADJ = 4.985; CI95% (2.85–8.72), p < 0.001]. An association between allele A carriers and HSIL development (p = 0.003) was also observed.ConclusionsIn the present study, we demonstrated that CXCL12 rs1801157 is independently associated with HPV infection and exerts influence in HSIL development, suggesting it as a promising susceptibility biomarker for HPV infection and lesions development.

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study

et al. 2018

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“…In addition, a silent sequence variant with a C/T substitution (+414 C > T; rs2228014) has been found in medulloblastomas, with no association between the +414 C>T variant and the subtype of medulloblastomas (30). Until now, numerous studies have reported that SDF-1 rs1801157 and CXCR4 rs2228014 are significantly associated with susceptibility to carcinogenesis in humans (28,(31)(32)(33)(34)(35)(36)(37)(38). However, the association of SDF-1 and CXCR4 polymorphisms with the risk and the clinicopathological development of OPSCC remain inconclusive and controversial (39,40).…”

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confidence: 99%

Association of SDF-1 and CXCR4 Polymorphisms With Susceptibility to Oral and Pharyngeal Squamous Cell Carcinoma

Huang

Tseng

et al. 2019

Anticancer Res

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Background/Aim: Long-term exposure to betel quid (BQ)-, cigarette-, and alcohol-induced chronic inflammation is a crucial risk factor for oral and pharyngeal squamous cell carcinoma (OPSCC) progression. We analyzed the genotypes of stromal-cell-derived factor-1 (SDF-1) and CXC-chemokine receptor-4 (CXCR4) and determined the association between their polymorphisms and the risk of OPSCC. Materials and Methods: This study consisted of 452 patients with pathologically proved OPSCC and 424 sex-and age-matched cancer-free controls. The genotypes of SDF-1 and CXCR4 were detected through the TaqMan real-time polymerase chain reaction (PCR) method. Results: Our data indicated that the C allele and C/C genotypes of CXCR4 were significantly associated with OPSCC [adjusted odds ratio (AOR)=1.41,

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CXCL12/CXCR4 axis gene variants contribute to an increased vulnerability to HPV infection and cervical oncogenesis

Okuyama

Cezar-dos-Santos

Trugilo

et al. 2022

J Cancer Res Clin Oncol

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Stromal cell-derived factor-1 G801A polymorphism and the risk factors for cervical cancer

Abstract: Abstract.Although certain studies have demonstrated no association between the stromal cell-derived factor-1 (SDF1-3')

Cited by 3 publications

References 36 publications

Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study

Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study

Association of SDF-1 and CXCR4 Polymorphisms With Susceptibility to Oral and Pharyngeal Squamous Cell Carcinoma

CXCL12/CXCR4 axis gene variants contribute to an increased vulnerability to HPV infection and cervical oncogenesis

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