Ga-67 Citrate and F-18 FDG Uptake in Spironolactone-Induced Gynecomastia

Fukuchi, Kazuki; Sasaki, Hideyuki; Yokoya, Takahiro; Noguchi, Teruo; Goto, Yoichi; Hayashida, Kentaro; Ishida, Yoshiteru

doi:10.1097/00003072-200502000-00008

Cited by 10 publications

(2 citation statements)

References 8 publications

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“…21 ). 66 – 68 Unilateral nodular gynecomastia with increased FDG uptake may mimic a primary or secondary tumor. 69 When interpreting FDG PET/CT as a staging tool in oncological male patients, one should consider gynecomastia as a possible cause for increased FDG uptake in the breast.…”

Section: Diseases Of the Male Breastmentioning

confidence: 99%

Spectrum of the Breast Lesions With Increased 18F-FDG Uptake on PET/CT

Dong

Wang

et al. 2016

Clinical Nuclear Medicine

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Interpretation of 18F-FDG PET/CT studies in breast is challenging owing to nonspecific FDG uptake in various benign and malignant conditions. Benign conditions include breast changes in pregnancy and lactation, gynecomastia, mastitis, fat necrosis, fibroadenoma, intraductal papilloma, and atypical ductal hyperplasia. Among malignancies, invasive ductal carcinoma and invasive lobular carcinoma are common histological types of breast carcinoma. Rarely, other unusual histological types of breast carcinomas (eg, intraductal papillary carcinoma, invasive micropapillary carcinoma, medullary carcinoma, mucinous carcinoma, and metaplastic carcinoma), lymphoma, and metastasis can be the causes. Knowledge of a wide spectrum of hypermetabolic breast lesions on FDG PET/CT is essential in accurate reading of FDG PET/CT. The purpose of this atlas article is to demonstrate features of various breast lesions encountered at our institution, both benign and malignant, which can result in hypermetabolism on FDG PET/CT imaging.

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Section: Diseases Of the Male Breastmentioning

confidence: 99%

Spectrum of the Breast Lesions With Increased 18F-FDG Uptake on PET/CT

Dong

Wang

et al. 2016

Clinical Nuclear Medicine

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“…[7] Glandular breast tissue may show moderate uptake of FDG. [8] Factors that affect FDG uptake of normal breast tissue are the mammographic density, age, and menstrual cycle.…”

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confidence: 99%

Increased F-FDG uptake in bilateral gynecomastia secondary to feminizing adrenal tumor: A rare case report and review of literature

et al. 2017

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A 21 year old male who presented with painful enlargement of both the breasts and a hyperestrogenic state, was found to harbor a heterogeneous mass arising from the right adrenal on contrast enhanced Computed Tomography abdomen. The mass was hypermetabolic with no regional, nodal or distant metastases on Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography /Computed Tomography examination. Notably, substantial tracer uptake was seen in bilateral gynecomastia. The patient underwent a right adrenalectomy with the histopathology report confirming adrenocortical carcinoma. This case demonstrates utility of FDG PET/CT in adrenocortical carcinoma. However, when interpreting FDG PET/CT as a staging tool in oncological male patients, one should consider gynecomastia as a possible cause for increased FDG uptake in the breast as it may lead to a false positive interpretation.

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