“…The artificial neural network (ANN), which is based on the brain's neural structure (Rosenblatt, 1958 ), raised the interest of scientific community worldwide in the field of medicine due to its potential for diagnostic and prognostic applications (Smith et al, 1988 ; Salim, 2004 ; Kamruzzaman et al, 2010 ; Patil and Mudholkar, 2012 ). It has been used in heart disease (Kamruzzaman et al, 2010 ), predicting headache, pre-diagnosis of hypertension (Sumathi and Santhakumaran, 2011 ), kidney stone diseases (Kumar and Abhishek, 2012 ), classifying breast masses to identify breast cancer (Das and Bhattacharya, 2008 ; Pandey et al, 2012 ), dermatologist-level classification of skin diseases/cancer (Bakpo and Kabari, 2011 ; Esteva et al, 2017 ), prediction of skin cancer and blood cancer (Payandeh et al, 2009 ; Esteva et al, 2017 ; Roffman et al, 2018a ), and diagnosis of PC (Sanoob et al, 2016 ). As an example of the workflow in these applications, classification of skin cancer was performed via a single convolutional neural network, which was trained with a dataset of 129,450 clinical images (Esteva et al, 2017 ).…”