GABA alleviates high glucose-induced podocyte injury through dynamically altering the expression of macrophage M1/M2-derived exosomal miR-21a-5p/miR-25-3p

Zhuang, Yibo; Zheng, Hongxue; Yang, Yong; Ni, Huiping

doi:10.1016/j.bbrc.2022.06.019

Cited by 13 publications

(4 citation statements)

References 19 publications

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“…Consequently, they have emerged as a promising therapeutic target for the treatment of CKD. Zhuang et al, 2022 demonstrated that GABA could mitigate the pro-inflammatory effects of macrophages on podocytes by modulating miR-21a-5p/miR-25-3p in macrophage-derived EVs. Ding et al, 2021 discovered that the exosome inhibitor GW4869 effectively attenuated cyst growth in Autosomal Dominant Polycystic Kidney Disease (ADPKD) and reduced macrophage infiltration in cystic kidneys.…”

Section: Therapeutic Role Of Evs In Chronic Kidney Diseasementioning

confidence: 98%

Extracellular vesicles in chronic kidney disease: diagnostic and therapeutic roles

Zheng,

Wang,

et al. 2024

Front. Pharmacol.

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Chronic kidney disease (CKD) is a progressive disorder characterized by structural and functional changes in the kidneys, providing a global health challenge with significant impacts on mortality rates. Extracellular vesicles (EVs), are vital in the physiological and pathological processes associated with CKD. They have been shown to modulate key pathways involved in renal injury, including inflammation, fibrosis, apoptosis, and oxidative stress. Currently, the application research of EVs in the diagnosis and treatment of CKD is highly prevalent. However, there is currently a lack of standardized guidelines for their application, and various methodologies have advantages and limitations. Consequently, we present an comprehensive summary elucidating the multifaceted involvement of EVs in both physiological and pathological aspects in CKD. Furthermore, we explore their potential as biomarkers and diverse therapeutic roles in CKD. This review provides an overview of the current state of research on application of EVs in the diagnosis and therapeutic management of CKD.

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Section: Therapeutic Role Of Evs In Chronic Kidney Diseasementioning

confidence: 98%

Extracellular vesicles in chronic kidney disease: diagnostic and therapeutic roles

Zheng,

Wang,

et al. 2024

Front. Pharmacol.

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“…Zhuang et al. [ 92 ] reported that G-aminobutyric acid (GABA) can regulate the Tnpo1/ATXN3 signaling pathway by affecting the expression of exosomal miR-21a-5p/miR-25-3 secreted by macrophages under HG conditions, thereby promoting podocyte proliferation and inhibiting podocyte apoptosis. Furthermore, Li et al.…”

Section: Therapeutic Perspectives Of Evs In Dkdmentioning

confidence: 99%

Research progress on the role of extracellular vesicles in the pathogenesis of diabetic kidney disease

Jin,

Zhang

2024

Renal Failure

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Diabetic kidney disease (DKD) is a serious complication of diabetes mellitus (DM) and has become the main cause of end-stage renal disease worldwide. In recent years, with the increasing incidence of DM, the pathogenesis of DKD has received increasing attention. The pathogenesis of DKD is diverse and complex. Extracellular vesicles (EVs) contain cell-derived membrane proteins, nucleic acids (such as DNA and RNA) and other important cellular components and are involved in intercellular information and substance transmission. In recent years, an increasing number of studies have confirmed that EVs play an important role in the development of DKD. The purpose of this paper is to explain the potential diagnostic value of EVs in DKD, analyze the mechanism by which EVs participate in intercellular communication, and explore whether EVs may become drug carriers for targeted therapy to provide a reference for promoting the implementation and application of exosome therapy strategies in clinical practice.

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“…The experiment conducted by ZHUANG et al. ( 51 ) to investigate the effect of γ-aminobutyric acid in high-glucose-induced podocyte injury showed that M1 macrophages aggravated high-glucose-induced podocyte injury by secreting exosomes to reduce the proliferation ability and increase the apoptosis rate of cells under high glucose conditions. In the study, miR-21a-5p expression was found to be significantly upregulated in macrophage-derived exosomes, and miR-25-3p expression showed no significant alteration.…”

Section: Exosomes Mediate Communication Between Other Cells and Podoc...mentioning

confidence: 99%

“…HUANG et al (50) further found that M2 macrophage-derived exosome miR-25-3p activated podocyte autophagy and attenuated podocyte apoptosis and EMT by inhibiting DUSP1 expression, thereby protecting podocytes from high-glucose-induced injury. The experiment conducted by ZHUANG et al (51) to investigate the effect of gaminobutyric acid in high-glucose-induced podocyte injury showed that M1 macrophages aggravated high-glucose-induced podocyte injury by secreting exosomes to reduce the proliferation ability and increase the apoptosis rate of cells under high glucose conditions. In the study, miR-21a-5p expression was found to be significantly upregulated in macrophage-derived exosomes, and miR-25-3p expression showed no significant alteration.…”

Section: Macrophage-derived Exosomes and Podocyte Injurymentioning

confidence: 99%

Research progress on exosomes in podocyte injury associated with diabetic kidney disease

Zheng

Chen

et al. 2023

Front. Endocrinol.

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Diabetic kidney disease (DKD), a common cause of end-stage renal disease, is a serious complication that develops with the progression of chronic diabetes. Its main clinical manifestations are persistent proteinuria and/or a progressive decline in the estimated glomerular filtration rate. Podocytes, terminally differentiated glomerular visceral epithelial cells, constitute the glomerular filtration barrier together with the basement membrane and endothelial cells, and the structural and functional barrier integrity is closely related to proteinuria. In recent years, an increasing number of studies have confirmed that podocyte injury is the central target of the occurrence and development of DKD, and research on exosomes in podocyte injury associated with DKD has also made great progress. The aim of this review is to comprehensively describe the potential diagnostic value of exosomes in podocyte injury associated with DKD, analyze the mechanism by which exosomes realize the communication between podocytes and other types of cells and discuss the possibility of exosomes as targeted therapy drug carriers to provide new targets for and insights into delaying the progression of and treating DKD.

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GABA alleviates high glucose-induced podocyte injury through dynamically altering the expression of macrophage M1/M2-derived exosomal miR-21a-5p/miR-25-3p

Cited by 13 publications

References 19 publications

Extracellular vesicles in chronic kidney disease: diagnostic and therapeutic roles

Extracellular vesicles in chronic kidney disease: diagnostic and therapeutic roles

Research progress on the role of extracellular vesicles in the pathogenesis of diabetic kidney disease

Research progress on exosomes in podocyte injury associated with diabetic kidney disease

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