GABA, glutamate, dopamine and serotonin transporters expression on memory formation and amnesia

Tellez, Ruth; Gómez-Víquez, Leticia; Meneses, Alfredo

doi:10.1016/j.nlm.2011.12.002

Cited by 36 publications

(22 citation statements)

References 68 publications

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“…CB 1 receptors are expressed in presynaptic terminals of excitatory neurons (Sharkey et al, 2014). Functionally, GABA A receptors seem to be located both pre-and post-synapses (Tellez et al, 2012). GABA A receptors are ionotropic receptors which couple to a Cl -ionophore (Jonaidi et al, 2012).…”

Section: Involvement Of Gaba and Cannabinoid Receptors In Central Foomentioning

confidence: 99%

Involvement of Gaba and Cannabinoid Receptors in Central Food Intake Regulation in Neonatal Layer Chicks: Role of CB1 and Gabaa Receptors

Zendehdel

Tirgari

Shohre

et al. 2017

Rev. Bras. Cienc. Avic.

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Feeding behavior is regulated via a complex network which interacts via diverse signals from central and peripheral tissues. Endocannabinoids modulate release of GABA in a variety of regions of the central nervous system. Endocannabinoids and GABAergic system have an important role in the central regulation of appetite. Thus, the present study examines the possible interaction of central canabinoidergic and GABAergic systems on food intake in 3-h food-deprived (FD 3 ) neonatal layer-type chicks. The results of this study showed that intracerebroventricular (ICV) injection of 2-AG (2-Arachidonoylglycerol, selective CB 1 receptors agonist, 2µg) significantly increased food intake and this effect of 2-AG was attenuated by Picrotoxin (GABA A antagonist, 0.5µg) (P<0.001); but 21ng CGP54626 (GABA B antagonist) had no effect (p>0.05).Also, hyperphagic effect of CB65 (CB 2 receptors agonist, 1.25µg) was not affected by Picrotoxin or CGP54626 (p>0.05). Moreover, the food intake of chicks was significantly increased by ICV injection of GABA A agonist (Gaboxadol, 0.2 µg) and SR141716A (CB 1 receptors antagonist, 6.25µg) significantly decreased Gaboxadol-induced hyperphagia (P<0.001) but CB 2 receptors antagonist (AM630, 1.25µg) had no effect. In contrast, co-injection of SR141716A or AM630 with GABA B agonist (baclofen, 0.2µg) had no effect on the hyperphagia induced by baclofen (p>0.05). These data showed there might be an interaction between central cannabinoidergic and GABAergic systems via CB 1 and GABA A receptors in control of food intake in neonatal layer chicks.

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Section: Involvement Of Gaba and Cannabinoid Receptors In Central Foomentioning

confidence: 99%

Involvement of Gaba and Cannabinoid Receptors in Central Food Intake Regulation in Neonatal Layer Chicks: Role of CB1 and Gabaa Receptors

Zendehdel

Tirgari

Shohre

et al. 2017

Rev. Bras. Cienc. Avic.

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“…5-HT drugs may present promnesic and/or antiamnesic effects. For instance, the effects of 5-HT endogenous on memory formation were studied by using a 5-HT uptake facilitator (tianeptine), facilitating memory consolidation and selective 5-HT 1À7 receptor antagonists reversed it (Meneses, 2002) interacting with other neurotransmission systems (Meneses, 2002;and also Briand et al, 2007;Tellez et al, 2012a). Notably, disorders such as AD and schizophrenia have an important component of dysfunctional memory; their etiology includes dysfunction of cholinergic, glutamatergic, and serotonergic systems (Berger et al, 2009;Engelborghs et al, 2013;Rodríguez et al, 2012), and certainly 5-HT has been also implicated in diseases with memory disorders, including depression, compulsive disorder, and posttraumatic stress disorder (Hermann et al, 2012;Jones and Moller, 2011;Millan et al, 2012;Vermetten and Lanius, 2012) (Table 2.1).…”

Section: -Ht Systems and Neurobiological Markers Related To Memory Smentioning

confidence: 99%

“…Importantly, determination if drugs, age and/or memory alone alter 5-HT 6 receptor expression and/or signal cascades is very important. Actually, memory tasks modify the expression of neurobiological markers (e.g., serotonergic receptors, SERT, signaling) (Marcos et al, 2010;Tellez et al, 2012aTellez et al, , 2012b. Likewise, even, different instruments for measuring memory also are relevant (see e.g., Gonzalez et al, 2013).…”

Section: -Ht Pathways Receptors and Transporter: Memory Functions mentioning

confidence: 99%

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Neurotransmitters and Memory

Meneses

2014

Identification of Neural Markers Accompanying Memory

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“…GABA exerts its effects by acting on two distinct receptors including the bicuculline-sensitive GABA A receptor and the bicuculline-insensitive GABA B receptors (Stratford and Wirtshafter 2013). Functionally, GABA A and GABA B receptors appear to be located both pre-and post synaptically (Tellez et al 2012). In avian species, it is reported ICV injection of a GABA A receptor agonist (muscimol) increased food intake in turkeys (Denbow 1991) and meat-type chicks (Jonaidi et al 2002;Zendehdel et al 2009), but ICV injection of a GABA B receptor agonist (baclofen) had no effect on food intake in meat-type chicks (Jonaidi et al 2002).…”

Section: Introductionmentioning

confidence: 99%

The interaction of central nitrergic and GABAergic systems on food intake in neonatal layer-type chicks

et al. 2016

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Most physiological behaviors such as food intake are controlled by the hypothalamus and its nuclei. It has been demonstrated that injection of the paraventricular nucleus of the hypothalamus with nitric oxide (NO) donors elicited changes in the concentration of some amino acids, including GABA. Also, central nitrergic and GABAergic systems are known to provide inputs to the paraventricular nucleus and are involved in food intake control. Therefore, the present study examines the probable interaction of central nitrergic and GABAergic systems on food intake in neonatal layer-type chicks. The results of this study showed that intracerebroventricular (ICV) injection of L-arginine (400 and 800 nmol), as a NO donor, significantly decreased food intake (P < 0.001), but ICV injection of Nω-Nitro-L-arginine methyl ester (L-NAME) (200 and 400 nmol), a NO synthesis inhibitor, increased food intake (P < 0.001). In addition, the orexigenic effect of gaboxadol (0.2 µg), a GABAA agonist, was significantly attenuated in ICV co-injection of L-arginine (200 nmol) and gaboxadol (0.2 µg) (P < 0.001), but it was significantly amplified in ICV co-injection of L-NAME (100 nmol) and gaboxadol (0.2 µg) (P < 0.001). On the other hand, the orexigenic effect of baclofen (0.2 µg), a GABAB agonist, did not change in ICV co-injection of L-arginine (200 nmol) or L-NAME (100 nmol) with baclofen (0.2 µg) (P > 0.05). Also, the hypophagic effect of L-arginine (800 nmol) was significantly amplified in ICV co-injection of picrotoxin (0.5 µg), a GABAA antagonist, or CGP54626 (21 ng), a GABAB antagonist, with L-arginine (800 nmol) (P < 0.001). These results probably suggest an interaction of central nitrergic and GABAergic systems on food intake in neonatal layer-type chicks and GABAA receptors play a major role in this interaction.

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GABA, glutamate, dopamine and serotonin transporters expression on memory formation and amnesia

Cited by 36 publications

References 68 publications

Involvement of Gaba and Cannabinoid Receptors in Central Food Intake Regulation in Neonatal Layer Chicks: Role of CB1 and Gabaa Receptors

Involvement of Gaba and Cannabinoid Receptors in Central Food Intake Regulation in Neonatal Layer Chicks: Role of CB1 and Gabaa Receptors

Neurotransmitters and Memory

The interaction of central nitrergic and GABAergic systems on food intake in neonatal layer-type chicks

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