Neurotransmitters and Memory

Meneses, Alfredo

doi:10.1016/b978-0-12-408139-0.00002-x

Cited by 6 publications

(2 citation statements)

References 250 publications

(320 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IR affects key neurotransmitters like acetylcholine, dopamine, and serotonin, essential for memory, mood, and cognitive function[ 129 - 131 ]. This imbalance leads to a disruption in the equilibrium between excitatory and inhibitory neurotransmissions, particularly impacting the cholinergic system and exacerbating memory loss[ 132 , 133 ]. Furthermore, IR-induced chronic inflammation and alterations in pathways of neurotrophic factors, notably brain-derived neurotrophic factor (BDNF), further destabilize neurotransmitter systems.…”

Section: Molecular Mechanisms Linking Ir To Admentioning

confidence: 99%

Insulin resistance as the molecular link between diabetes and Alzheimer's disease

Abdalla

2024

World J Diabetes

View full text Add to dashboard Cite

Diabetes mellitus (DM) and Alzheimer's disease (AD) are two major health concerns that have seen a rising prevalence worldwide. Recent studies have indicated a possible link between DM and an increased risk of developing AD. Insulin, while primarily known for its role in regulating blood sugar, also plays a vital role in protecting brain functions. Insulin resistance (IR), especially prevalent in type 2 diabetes, is believed to play a significant role in AD's development. When insulin signalling becomes dysfunctional, it can negatively affect various brain functions, making individuals more susceptible to AD's defining features, such as the buildup of beta-amyloid plaques and tau protein tangles. Emerging research suggests that addressing insulin-related issues might help reduce or even reverse the brain changes linked to AD. This review aims to explore the rela-tionship between DM and AD, with a focus on the role of IR. It also explores the molecular mechanisms by which IR might lead to brain changes and assesses current treatments that target IR. Understanding IR's role in the connection between DM and AD offers new possibilities for treatments and highlights the importance of continued research in this interdisciplinary field.

show abstract

Section: Molecular Mechanisms Linking Ir To Admentioning

confidence: 99%

Insulin resistance as the molecular link between diabetes and Alzheimer's disease

Abdalla

2024

World J Diabetes

View full text Add to dashboard Cite

show abstract

“…These processes require neurotransmitter receptors for the acquisition and storage of new memories [36]. Examples of these are N-methyl-D-aspartate (NMDA) [52], Adenosine A2A [53], dopamine Drd1a [54], AMPA, GABA and metabotropic glutamate receptors [36], as well as acetylcholine, serotonin and norepinephrine [55,56]. It has been established that during the consolidation process, the medial temporal areas play a critical role; this system undergoes several functions related to memory, such as encoding, consolidation and retrieval.…”

Section: Molecular Mechanisms Behind Memorymentioning

confidence: 99%

l-Lactate: Food for Thoughts, Memory and Behavior

2021

View full text Add to dashboard Cite

More and more evidence shows how brain energy metabolism is the linkage between physiological and morphological synaptic plasticity and memory consolidation. Different types of memory are associated with differential inputs, each with specific inputs that are upstream diverse molecular cascades depending on the receptor activity. No matter how heterogeneous the response is, energy availability represents the lowest common denominator since all these mechanisms are energy consuming and the brain networks adapt their performance accordingly. Astrocytes exert a primary role in this sense by acting as an energy buffer; glycogen granules, a mechanism to store glucose, are redistributed at glance and conveyed to neurons via the Astrocyte–Neuron Lactate Shuttle (ANLS). Here, we review how different types of memory relate to the mechanisms of energy delivery in the brain.

show abstract

Autoshaping Memory Formation and Retention Loss: Are Serotonin and Other Neurotransmitter Transporters Involved?

Meneses

Tellez

2014

Neuromethods

View full text Add to dashboard Cite

Neurotransmitters and Memory

Cited by 6 publications

References 250 publications

Insulin resistance as the molecular link between diabetes and Alzheimer's disease

Insulin resistance as the molecular link between diabetes and Alzheimer's disease

l-Lactate: Food for Thoughts, Memory and Behavior

Autoshaping Memory Formation and Retention Loss: Are Serotonin and Other Neurotransmitter Transporters Involved?

Contact Info

Product

Resources

About