GABAA receptors in the basolateral amygdala are involved in mediating morphine reward

Zarrindast, Mohammad‐Reza; Ahmadi, Shamseddin; Haeri-Rohani, Ali; Rezayof, Ameneh; Jafari, Mohammad-Reza; Jafari‐Sabet, Majid

doi:10.1016/j.brainres.2003.12.048

Cited by 53 publications

(28 citation statements)

References 61 publications

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“…The BLA is known to be important for stimuluscontrolled behaviors, and lesions or chemical inactivation of this structure can result in the loss of both CPP acquisition [16,18,59] and cue-induced reinstatement of drug self-administration [17,50,57]. Lesions of the Cg do not impair reward seeking or consumption of rewards per se, but instead disrupt the ability to discriminate between a rewarded stimulus (CS+) and an unrewarded stimulus (CS-), causing an animal to approach both stimuli in an equal manner [5][6][7]43].…”

Section: Discussionmentioning

confidence: 99%

Activation in extended amygdala corresponds to altered hedonic processing during protracted morphine withdrawal

Harris

Aston‐Jones

2007

Behavioural Brain Research

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Previously we reported that during protracted morphine abstinence rats show reduced conditioned place preferences (CPP) for food-associated environments, compared to non-dependent subjects. To determine the brain regions involved in this altered reward behavior, we examined neural activation (as indexed by Fos-like proteins) induced by a preference test for a food-associated environment in five-week morphine-abstinent vs non-dependent animals. The results indicate that elevated Fos expression in the anterior cingulate cortex (Cg) and basolateral amygdala (BLA) correlated positively with preference behavior in all groups. In contrast, Fos expression in stress-associated brain areas, including the ventral lateral bed nucleus of the stria terminalis (VL-BNST), central nucleus of the amygdala (CE), and noradrenergic (A2) neurons in the nucleus tractus solitarius (NTS) was significantly elevated only in morphine-abstinent animals. Furthermore, the number of Fos positive neurons in these areas was found to correlate negatively with food preference in abstinent animals. These results indicate that the altered hedonic processing during protracted morphine withdrawal leading to decreased preference for cues associated with natural rewards may involve heightened activity in stress-related brain areas of the extended amygdala and their medullary noradrenergic inputs.

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Section: Discussionmentioning

confidence: 99%

Activation in extended amygdala corresponds to altered hedonic processing during protracted morphine withdrawal

Harris

Aston‐Jones

2007

Behavioural Brain Research

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“…Nevertheless treatments most of these methods have given unsatisfied results until now [1]. According to the results of previous studies, several neurotransmitter systems, including dopamine, glutamate, acetylcholine, GABA, histamine and nitric oxide have been implicated in rewarding properties of morphine [3,4].…”

Section: Introductionmentioning

confidence: 99%

Treadmill exercise reduces self-administration of morphine in male rats

et al. 2009

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“…For instance working memory was impaired by intra-septal (Yamamoto et al, 2007) and intra-hippocampal (Ohno et al, 1992) injections of this drug. It was also shown that intra-BLA injection of muscimol reduced the acquisition of conditioned place preference (CPP) induced by morphine (Zarrindast et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have shown that GABA A receptors are involved in modulation of memory processes (Izquierdo et al, 1990;Myhrer, 2003;Zarrindast et al, 2004). There is a high density of GABA A receptors in most regions of the brain including the amygdaloid complex (Salinas and McGaugh, 1996) and the hippocampus (Mao and Robinson, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Involvement of basolateral amygdala GABAA receptors in the effect of dexamethasone on memory in rats

Khajehpour

Alizadeh-Makvandi

Kesmati

et al. 2011

J. Zhejiang Univ. Sci. B

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Abstract:In this study we investigated whether GABA A receptors of the basolateral amygdala (BLA) interact with the effect of dexamethasone on the retrieval stage of memory. Adult male Wistar rats were bilaterally cannulated in the BLA by stereotaxic surgery. The animals were trained in step-through apparatus by induction of electric shock (1.5 mA, 3 s) and were tested for memory retrieval after 1 d. The time of latency for entering the dark compartment of the instrument and the time spent by rats in this chamber were recorded for evaluation of the animals' retrieval in passive avoidance memory. Administration of dexamethasone (0.3 and 0.9 mg/kg, subcutaneously (s.c.)), immediately after training, enhanced memory retrieval. This effect was reduced by intra-BLA microinjection of muscimol (0.125, 0.250 and 0.500 µg/rat), when administered before 0.9 mg/kg of dexamethasone. Microinjection of bicuculline (0.75 µg/rat, intra-BLA) with an ineffective dose of dexamethasone (0.1 mg/kg, s.c.) increased memory retrieval. However, the same doses of muscimol and bicuculline without dexamethasone did not affect memory processes. Our data support reports that dexamethasone enhances memory retrieval. It seems that GABA A receptors of the BLA mediate the effect of dexamethasone on memory retrieval in rats.

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GABAA receptors in the basolateral amygdala are involved in mediating morphine reward

Cited by 53 publications

References 61 publications

Activation in extended amygdala corresponds to altered hedonic processing during protracted morphine withdrawal

Activation in extended amygdala corresponds to altered hedonic processing during protracted morphine withdrawal

Treadmill exercise reduces self-administration of morphine in male rats

Involvement of basolateral amygdala GABAA receptors in the effect of dexamethasone on memory in rats

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