GABAergic blockade of cocaine-associated cue-induced increases in nucleus accumbens dopamine

Gerasimov, Madina R.; Schiffer, Wynne K.; Gardner, Eliot L.; Marsteller, Douglas; Lennon, Ian C.; Taylor, Stephen J.; Brodie, Jonathan D.; Ashby, Charles R.; Dewey, Stephen L.

doi:10.1016/s0014-2999(01)00800-7

Cited by 50 publications

(34 citation statements)

References 21 publications

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“…Therefore, in an extensive series of preclinical rodent and primate studies using in vivo microdialysis and PET, respectively, we reported that GVG blocked drug and cue-induced increases in nucleus accumbens and striatal DA Gerasimov et al, 2001;Morgan et al, 1997;Morgan and Dewey, 1998). Further, we demonstrated that GVG blocked cocaine self-administration and cocaineinduced lowering of brain stimulation reward thresholds (Kushner et al, 1997).…”

mentioning

confidence: 62%

Treating cocaine addiction: From preclinical to clinical trial experience with γ‐vinyl GABA

Brodie

Figueroa²,

Dewey

2003

Synapse

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mentioning

confidence: 62%

Treating cocaine addiction: From preclinical to clinical trial experience with γ‐vinyl GABA

Brodie

Figueroa²,

Dewey

2003

Synapse

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“…On the other hand, Wise and colleagues have argued compellingly for a crucial role for meso-accumbens DA in the actual mediation of reward-if not a final common path for all rewards, at least an intermediate common path for most rewards [303], and we [104] and others [34,46,79,139,140,220,288] have argued that elevation of brain DA constitutes a neurochemical substrate of the reward produced by addictive drugs (and by drug-associated environmental cues; see e.g., Refs. [82,109,141]), not merely a correlate.…”

Section: Discussionmentioning

confidence: 98%

“…In this regard, the absence of SB-277011-A dose-dependence in blocking cocaine-induced CPP within the dose range used in the reported experiments may be relevant; dose dependence may exist at lower doses. Similarly, it is possible that cocaineassociated cue-induced increases in forebrain DA are substantially lower than cocaineinduced increases [35,109], and perhaps easier for D 3 antagonism to surmount.…”

Section: Summary Of Effects Of Sb-277011-a On Addictive Drug Actionmentioning

confidence: 99%

The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence

Heidbreder

Gardner

et al. 2005

Brain Research Reviews

305

249

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The cDNA for the dopamine D 3 receptor was isolated and characterized in 1990. Subsequent studies have indicated that D 3 receptors, as well as D 3 receptor mRNA, are primarily localized in limbic regions in mammals. This finding led to the postulate that D 3 receptors may be involved in drug dependence and addiction. However, this hypothesis has been difficult to test due to the lack of compounds with high selectivity for central D 3 receptors. The interpretation of results from studies using mixed D 2 /D 3 agonists and/or antagonists is problematic because these agents have low selectivity for D 3 over D 2 receptors and it is likely that their actions are primarily related to D 2 receptor antagonism and possibly interaction with other neurotransmitter receptors. Currently, with the synthesis and characterization of new highly selective D 3 receptor antagonists such as SB-277011-A this difficulty has been surmounted. The purpose of the present article is to review, for the first time, the effects of various putative D 3 receptor selective compounds in animal models of drug dependence and addiction. The results obtained with highly selective D 3 receptor antagonists such as SB-277011-A, SB-414796, and NGB-2904 indicate that central D 3 receptors may play an important role in drug-induced reward, drug-taking, and cue-, drug-, and stressinduced reinstatement of drug-seeking behavior. Provided these results can be extrapolated to human drug addicts, they suggest that selective DA D 3 receptor antagonists may prove effective as potential pharmacotherapeutic agents to manage drug dependence and addiction.

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“…Pretreatment with the GABA receptor agonist vigabatrin blocked conditioned increases in nucleus accumbens DA efflux (Gerasimov et al, 2001) that were associated with exposure to environmental stimuli predictive of drug reward (Di Ciano et al, 1998a, b;Weiss et al, 2000). Thus, baclofen may attenuate conditioned increases in DA efflux via actions on ventral tegmental DA neurons, as further indicated by the observation that its infusion directly into the VTA disrupted conditioned place preference to a morphine-paired environment (Tsuji et al, 1996).…”

Section: Potential Mechanism By Which Baclofen Reduced Cocaine-and Hementioning

confidence: 98%

The GABAB Receptor Agonist Baclofen Attenuates Cocaine- and Heroin-Seeking Behavior by Rats

Ciano

Everitt

2002

Neuropsychopharmacol

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Conditioned stimuli paired with drugs of abuse can acquire motivational properties, and are capable of inducing drug-seeking behavior and relapse to cocaine use. Converging evidence implicates the mesolimbic dopamine (DA) system, through interactions with limbic afferents to the nucleus accumbens, in behavior controlled by conditioned stimuli. The GABA B receptor agonist baclofen has been shown to decrease break points in rats responding for cocaine under progressive ratio schedules and also to attenuate activation of limbic cortical areas in human cocaine addicts. The purpose of the present study was therefore to investigate the effects of baclofen on drug-associated cue-controlled cocaine-or heroin-seeking behavior by rats. Under the second-order schedule of reinforcement used in the present study, cocaine or heroin were available after a fixed time interval, while high rates of responding during the interdrug intervals were maintained by the response-contingent presentations of drug-associated conditioned reinforcers. Baclofen decreased stimulusmaintained responding for either heroin or cocaine, but decreased only cocaine intake under an FR1 schedule. These results therefore support preliminary clinical findings and suggest that drugs with GABA B receptor agonist properties may aid abstinence in human drug addicts by decreasing the propensity to cue-induced drug-seeking and relapse.

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GABAergic blockade of cocaine-associated cue-induced increases in nucleus accumbens dopamine

Cited by 50 publications

References 21 publications

Treating cocaine addiction: From preclinical to clinical trial experience with γ‐vinyl GABA

Treating cocaine addiction: From preclinical to clinical trial experience with γ‐vinyl GABA

The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence

The GABAB Receptor Agonist Baclofen Attenuates Cocaine- and Heroin-Seeking Behavior by Rats

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