GABAergic control of food intake in the meat-type chickens

Jonaidi, Hossein; Babapour, Vahab; Denbow, D. Michael

doi:10.1016/s0031-9384(02)00692-3

Cited by 47 publications

(24 citation statements)

References 31 publications

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“…As an inhibitory neurotransmitter, GABA is widely present in the central nervous system and peripheral tissues; it can promote food intake in animals, regulate endocrine, autoimmune, hormonal, and reproductive physiology, and improve functions of anti-hypoxia, anti-HS, etc. in animals (Chen et al, 2001;Jonaidi et al, 2002;Chen et al, 2014;Chen et al, 2015). GABA exerts its biological functions via interaction with GABA receptor.…”

Section: Introductionmentioning

confidence: 99%

Effect of Heat Stress on the Expression of GABA Receptor mRNA in the HPG Axis of Wenchang Chickens

Xie

et al. 2016

Rev. Bras. Cienc. Avic.

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We investigated the effect of heat stress (HS) on the expression of the GABA receptor in the hypothalamic-pituitary-gonadal (HPG) axis of Wenchang chickens. Real-time quantitative RT-PCR (qRT-PCR) was used to quantify the GABA receptor mRNA levels along the HPG axis of chickens under HS (40±0.5 °C) for 1-6 weeks. Our results showed that the expression of GABA A and GABA B receptor at the mRNAs levels in the tissues of HPG axis exhibited fluctuation and variability. After HS, the mRNA level of GABA A receptor was significantly reduced in the hypothalamus of 1-week-old and in the pituitary of 3-week-old chickens, but significantly increased in the pituitary of 1-, 4-, and 5-weekold chickens. The GABA B receptor mRNA level significantly declined in the hypothalamus of 1-week-old and in the pituitary of 3-week-old chickens, but was significantly upregulated in the pituitary and testis of 1-and 2-week-old chickens. At other time points, the expressions of GABA A receptor and GABA B receptor showed no significant differences compared with control group. These results indicated that the levels of GABA A receptor and GABA B receptor mRNAs varied in different tissues of the HPG axis in chickens of different ages, displaying temporal and spatial variations. GABA receptor behaved as a positively-regulated gene by HS, i.e., its mRNA was increased by HS; similarly, it was a negativelyregulated gene by HS, when its expression was reduced by HS.

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Section: Introductionmentioning

confidence: 99%

Effect of Heat Stress on the Expression of GABA Receptor mRNA in the HPG Axis of Wenchang Chickens

Xie

et al. 2016

Rev. Bras. Cienc. Avic.

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“…It appears GABA has orexigenic effect in domestic fowls (Jonaidi et al, 2012). ICV injection of Muscimol (a GABA A agonist) and Baclofen (a GABA B agonist) increased food consumption in rats (Ebenezer, 1990), turkeys (Denbow, 1991), meat-type (broiler) and layer-type chicks (hens) (Jonaidi et al, 2002). Both CB 1 and CB 2 receptors have a role in food intake regulation in the rat (Chen et al, 2006).…”

Section: Involvement Of Gaba and Cannabinoid Receptors In Central Foomentioning

confidence: 99%

“…For example, food intake mediates via both CB 1 and CB 2 receptors in layer-type chicken (Alizadeh et al, 2015) but only CB 2 receptors interact on feeding in meat-type chicken (Emadi et al, 2011;Novoseletsky et al, 2011). For instance, ICV injection of Baclofen had no effect on food intake in broilers (Jonaidi et al, 2002;Tajalli et al, 2006;Zendehdel et al, 2008Zendehdel et al, , 2009.…”

Section: Involvement Of Gaba and Cannabinoid Receptors In Central Foomentioning

confidence: 99%

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Involvement of Gaba and Cannabinoid Receptors in Central Food Intake Regulation in Neonatal Layer Chicks: Role of CB1 and Gabaa Receptors

Zendehdel

Tirgari

Shohre

et al. 2017

Rev. Bras. Cienc. Avic.

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Feeding behavior is regulated via a complex network which interacts via diverse signals from central and peripheral tissues. Endocannabinoids modulate release of GABA in a variety of regions of the central nervous system. Endocannabinoids and GABAergic system have an important role in the central regulation of appetite. Thus, the present study examines the possible interaction of central canabinoidergic and GABAergic systems on food intake in 3-h food-deprived (FD 3 ) neonatal layer-type chicks. The results of this study showed that intracerebroventricular (ICV) injection of 2-AG (2-Arachidonoylglycerol, selective CB 1 receptors agonist, 2µg) significantly increased food intake and this effect of 2-AG was attenuated by Picrotoxin (GABA A antagonist, 0.5µg) (P<0.001); but 21ng CGP54626 (GABA B antagonist) had no effect (p>0.05).Also, hyperphagic effect of CB65 (CB 2 receptors agonist, 1.25µg) was not affected by Picrotoxin or CGP54626 (p>0.05). Moreover, the food intake of chicks was significantly increased by ICV injection of GABA A agonist (Gaboxadol, 0.2 µg) and SR141716A (CB 1 receptors antagonist, 6.25µg) significantly decreased Gaboxadol-induced hyperphagia (P<0.001) but CB 2 receptors antagonist (AM630, 1.25µg) had no effect. In contrast, co-injection of SR141716A or AM630 with GABA B agonist (baclofen, 0.2µg) had no effect on the hyperphagia induced by baclofen (p>0.05). These data showed there might be an interaction between central cannabinoidergic and GABAergic systems via CB 1 and GABA A receptors in control of food intake in neonatal layer chicks.

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“…Intracerebroventricular (i.c.v.1 injections of GABA receptor agonists have been shown L-pipecolic acid increased release of site(s) in the brain (Charles, 1986). Together, y-amino butyric acid (GABA), decreased its uptake in mouse brain slices (Gutierrez and Delgado-Coello, 1989) and enhanced the GABA response in rat neurons (Takahama t o increase food intake in rats (Pu et al, 1999) and chicks (Jonaidi et al, 2002;Bungo et al, 2003), which was significantly attenuated by pretreatment with bicuculline (a GABA(A) antagonist) (Pu et al, 1999;Jonaidi et al, 2002). We have previously demonstrated that i.c.v.…”

Section: Introductionmentioning

confidence: 99%

Effect of Intracerebroventricular Injection of L-pipecolic Acid on GAB A Concentrations in Brain Sites of Neonatal Chicks

Takagi

Choi

Tachibana

et al. 2005

Journal of Applied Animal Research

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GABAergic control of food intake in the meat-type chickens

Cited by 47 publications

References 31 publications

Effect of Heat Stress on the Expression of GABA Receptor mRNA in the HPG Axis of Wenchang Chickens

Effect of Heat Stress on the Expression of GABA Receptor mRNA in the HPG Axis of Wenchang Chickens

Involvement of Gaba and Cannabinoid Receptors in Central Food Intake Regulation in Neonatal Layer Chicks: Role of CB1 and Gabaa Receptors

Effect of Intracerebroventricular Injection of L-pipecolic Acid on GAB A Concentrations in Brain Sites of Neonatal Chicks

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