Gabapentin attenuates intestinal inflammation: Role of PPAR-gamma receptor

Brito, Tarcísio Vieira de; Júnior, Genilson José Dias; Júnior, José Simião da Cruz; Silva, Renan Oliveira; Monteiro, Carlos Eduardo da Silva; Franco, Álvaro Xavier; Vasconcelos, Daniel Fernando Pereira; Oliveira, Jefferson Soares de; Costa, Deiziane Viana da Silva; Carneiro, Teiliane Rodrigues; Duarte, Antoniella Souza Gomes; Souza, Marcellus H.; Soares, Pedro Marcos Gomes; Barbosa, André Luiz dos Reis

doi:10.1016/j.ejphar.2020.172974

Cited by 32 publications

(17 citation statements)

References 48 publications

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“…Recently we showed that gabapentin has a significant anti-inflammatory action in models of inflammatory bowel diseases (de Brito et al, 2020); in this same research, we show that this effect attributed to GBP is due in part to its interrelation with the PPAR-gamma receptor. Even though we know about this GBP mechanism of action, we need to further unravel the alternative pathways by which GBP may be acting during its intestinal anti-inflammatory effect.…”

Section: Discussionsupporting

confidence: 57%

“…In addition, they can result in significant side effects and severe recurrence spikes. Therefore, new strategies against IBD are necessary ( de Brito et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Evidence points also that, peroxisome proliferator-activated receptors, PPARs modulate the activity of endocannabinoids receptors (O'Sullivan, 2016). In addition, GBP exerts its intestinal anti-inflammatory activity by activating the PPAR-gamma receptor (de Brito et al, 2020). For these reasons, we believe that GBP may also have some relationship with other CBs.…”

Section: Introductionmentioning

confidence: 86%

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Gabapentin improves colonic inflammatory damage and oxidative stress on acetic acid-induced colitis independent of cannabinoid pathway

Batista¹,

Magalhães²,

Sousa³

et al. 2021

RSD

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Objective: Gabapentin (GBP) possess a systemic anti-inflammatory action confirmed and endocannabinoids system have been effectives in reduces inflammatory disorders on intestinal tract. The aim of this study is evaluate the participation of the endogenous cannabinoids pathway in the anti-inflammatory and antioxidant effects of GBP in acetic acid (AA) induced colitis in mice. Methods: Colitis induction was performed using AA (6%) and mice treated intraperitoneally with GBP or dexamethasone (subcutaneously) at 17 h or 17:30 h after induction of colitis, respectively. After 18 h of colitis induction, the animals were euthanized and colonic sample was taken for evaluation of macroscopic and microscopic lesion, wet weight and biochemical analyzes. Results: The administration of GBP was effective in reduce the macro and microscopic lesions, significant decreasing the colonic wet weight of colitis mice. The drug reduced the concentration myeloperoxidase (MPO), malondialdehyde (MDA) and interleukin 1 (IL-1) and increased the level glutathione (GSH) in colitis mice compared to normal mice. The treatment with endocannabinoids (ECs) receptors antagonists did not alter the GBP effect. Conclusion: Gabapentin was able to reduce inflammatory parameters in acid acetic-induced colitis, but its effect seems to be independent of cannabinoid pathway.

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Section: Discussionsupporting

confidence: 57%

“…In addition, they can result in significant side effects and severe recurrence spikes. Therefore, new strategies against IBD are necessary ( de Brito et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 86%

See 1 more Smart Citation

Gabapentin improves colonic inflammatory damage and oxidative stress on acetic acid-induced colitis independent of cannabinoid pathway

Batista¹,

Magalhães²,

Sousa³

et al. 2021

RSD

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“…32 Brito et al reported that gabapentin has anti-inflammatory effects and reduces the levels of inflammatory parameters. 33 There are a couple of limitations in our study such as the small number of patients, variable treatment periods, and different drug dosages.…”

Section: Discussionmentioning

confidence: 98%

The efficacy of alpha-lipoic acid and/or gabapentin on the oxidant-antioxidant system in patients with diabetic polyneuropathy

Kömürcü

Baran²,

Erel

et al. 2020

Int J Res Med Sci

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Background: Diabetic peripheral sensorimotor polyneuropathy is the most common complication seen in patients with diabetes mellitus (DM). Oxidant system plays a crucial role in its physiopathology. We investigated the changes in the serum levels of total antioxidant status (TAS), total oxidant status (TOS), paraoxonase-1 (PON1) and oxidative stress index (OSI) to evaluate the antioxidant efficacy of alpha lipoic acid (ALA) and/or gabapentin in patients with diabetic polyneuropathy (DPN).Methods: Sixty-three type 2 DM patients with diabetic polyneuropathy (DPN) were enrolled in the study. Patients with DPN were divided into four groups in terms of their treatment: Group 1 consisted of treatment-naive patients; patients treated with ALA, gabapentin or combination of ALA and gabapentin comprised groups 2, 3, and 4, respectively. The patients received the medications for at least six weeks. Serum levels of TAS, TOS, PON1 and OSI were analyzed.Results: No significant difference was observed between the groups according to the oxidative stress parameters studied.Conclusions: The use of ALA and/or gabapentin in patients with DPN did not significantly affect the oxidative stress parameters, including TAS, TOS, PON1, and OSI.

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“…Colitis was induced as previously described (Rodrigues et al 2018;Brito et al 2020). The animals underwent a fasting period of 12-14 h, every day before PLS administration, at the end of the third day and after the last treatment and before euthanasia the animals were fasting.…”

Section: Colitis Model Assaymentioning

confidence: 99%

Sulfated Polysaccharide from Digenea simplex Decreases Intestinal Inflammation in Rats

Monturil

Brito

Júnior

et al. 2020

Rev. Bras. Farmacogn.

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Sulfated polysaccharides derived from seaweeds have important biological activities. The aim of this work was to demonstrate the anti-inflammatory effect of a sulfated polysaccharide extracted from the seaweed Digenea simplex (Wulfen) C. Agardh 1822 on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats. After inducing colitis, rats were euthanized, and the colon was excised to determine macroscopic lesion scores and wet weight and to histologically evaluate and quantify glutathione, malondialdehyde, myeloperoxidase, nitrate/nitrite, and cytokines. The polysaccharide, composed of β-D-galactose and 3,6-α-L-anhydrogalactose residues, reduced wet weight as well as macroscopic and microscopic lesion scores. It also reduced myeloperoxidase activity; reduced proinflammatory cytokines, malondialdehyde, and nitrate/nitrite levels; and preserved glutathione consumption in the colon. According to these results, we can infer that the sulfated polysaccharide derived from D. simplex has an anti-inflammatory effect on induced colitis in vivo.

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Gabapentin attenuates intestinal inflammation: Role of PPAR-gamma receptor

Cited by 32 publications

References 48 publications

Gabapentin improves colonic inflammatory damage and oxidative stress on acetic acid-induced colitis independent of cannabinoid pathway

Gabapentin improves colonic inflammatory damage and oxidative stress on acetic acid-induced colitis independent of cannabinoid pathway

The efficacy of alpha-lipoic acid and/or gabapentin on the oxidant-antioxidant system in patients with diabetic polyneuropathy

Sulfated Polysaccharide from Digenea simplex Decreases Intestinal Inflammation in Rats

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