Gabapentin-Induced Myopathy in 2 Patients on Short Daily Hemodialysis

Lipson, Jennifer; Lavoie, Susan; Zimmerman, Deborah

doi:10.1053/j.ajkd.2005.02.024

Cited by 11 publications

(9 citation statements)

References 21 publications

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“…In contrast with the acute episode observed in the present case, the onset of myopathy in the 2 previous patients appeared after some weeks of treatment with gabapentin. However, our patient was older and received a daily dose of gabapentin 4.5-fold higher in comparison with dose regimens reported by Lipson et al 16 In all cases, concomitant medications (atorvastatin, 17 sertraline, 18 and haloperidol and lansoprazole in our patient) might be regarded as having contributed to the onset of myopathy, while other possible causes (trauma, compartmental syndrome, infections, thyroid diseases, intense physical activity) were ruled out. Electromyographic recordings, as well as muscle and nerve histopathologic examinations, were not reported for the previously described patients.…”

Section: Discussionmentioning

confidence: 56%

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Gabapentin-Induced Severe Myopathy

et al. 2007

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Pathogenetic and clinical investigations are required to explore what mechanisms account for gabapentin-related muscular alterations at the time of onset, including electromyographic recordings as well as muscle and nerve histopathologic examinations. Until more information is available, clinicians should consider the possibility of discontinuing gabapentin treatment in patients showing muscular pain and signs of myopathy.

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Section: Discussionmentioning

confidence: 56%

“…16 The first was a 52-year-old man with end-stage renal disease who had been on short daily hemodialysis for 6 months. Concomitant drug treatments included ranitidine, sertraline, erythropoietin, and vitamins.…”

Section: Discussionmentioning

confidence: 99%

Gabapentin-Induced Severe Myopathy

et al. 2007

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Section: Discussionmentioning

confidence: 99%

“…To our knowledge, there are only five cases of gabapentin‐associated rhabdomyolysis in the literature (Table ). Lipson et al reported two cases of myopathy in patients receiving daily hemodialysis. These patients were taking low gabapentin doses (100 mg/day) and displayed lower CPK level elevation and a longer symptoms onset time (4 weeks and 6 weeks, respectively) than other cases.…”

Section: Discussionmentioning

confidence: 99%

A case of gabapentin‐induced rhabdomyolysis requiring renal replacement therapy

Choi

Jeon

Kim

et al. 2016

Hemodialysis International

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Gabapentin is commonly used for controlling convulsions, restless pain syndrome, and pain in diabetic neuropathy. Common side effects include dizziness, somnolence, ataxia, peripheral edema, and confusion; gabapentin-induced rhabdomyolysis is rarely reported. To date, the reported cases of gabapentin-induced rhabdomyolysis have been associated with patients with multiple underlying diseases and assuming multiple medicines for various reasons. In this report, we describe a case of gabapentin-induced rhabdomyolysis in a 32-year-old woman with no medical history. We also review related literature and discuss the possible mechanism and the association with other factors. This case shows that gabapentin can induce rhabdomyolysis in healthy patients and that clinicians must consider the possible association between gabapentin and rhabdomyolysis.

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“…In the literature, to the best of our knowledge, there are two case reports with respect to GBP use and myopathy (4,5 (11,12). In literature, published cases of GBP related adverse events including rhabdomyolysis occurred mostly in the setting of either acute or chronic renal dysfunction (4,5,(13)(14)(15) (5,16,17).…”

Section: In This Report We Presented a Case Of Rhabdomyolysis Complicmentioning

confidence: 99%