Gac (Momordica cochinchinensis (Lour) Spreng.) Oil

Cang, Huỳnh; Debaste, Frédéric

doi:10.1007/978-3-030-12473-1_18

Cited by 6 publications

(2 citation statements)

References 44 publications

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“…17 Compound A3, a white solid, was identified as chondrillasterol (stigmasta-7,22-dien-3β-ol, molecular weight 397.3148 and molecular formula C 29 H 48 O). 18 , 19 Compound A4, a yellow solid, was identified as lutein (molecular weight 568.9 and molecular formula C 40 H 56 O 2 ). 20…”

Section: Resultsmentioning

confidence: 99%

Antiulcerogenic effects of Celosia trigyna plant extracts on ethanol-induced gastric ulcer in adult Wistar rats

Ofusori

Moodley

Jonnalagadda

2020

Journal of Traditional and Complementary Medicine

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Background and aim Gastric ulcer is a chronic disease and serious health issue. Celosia trigyna is a medicinal plant used traditionally for wound healing. This study aimed to isolate the bioactive compounds from Celosia trigyna and to investigate the in vitro and in vivo anti-ulcerogenic effects of the extract s on ethanol-induced gastric ulcer on adult Wistar rats to determine their regenerative potential. Experimental procedure Seven groups (A – negative control, B – vehicle control, C, D, E, F and G – positive control, n = 5) of five adult Wistar rats received treatment for ethanol-induced gastric ulcer. Results and conclusion Phytochemical analysis led to the isolation of chondrillasterol, lutein, pheophytin a and chondrillasterol acetate. The in vitro results showed dichloromethane and hexane extracts to have maximum chymotrypsin inhibition relative to the standard (chymostatin) while in vivo results showed a significant increase in ulcer parameters of the vehicle control relative to groups treated with plant extracts (P < 0.05). Ulcer parameters and DNA density in groups treated with dichloromethane and hexane extracts were comparable to the negative control. Gross and histopathological findings confirmed gastric mucosa lesions in the vehicle control. There were mild ulcerations in groups treated with the ethyl acetate and methanol extracts with no observable ulcerations in the groups treated with dichloromethane and hexane extracts as the histoarchitectural outlines do not show any form of necrosis, distortion or cellular vacuolation. It was concluded that non-polar, hydrophobic compounds are able to remediate the degree of ulceration but not polar compounds.

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Section: Resultsmentioning

confidence: 99%

Antiulcerogenic effects of Celosia trigyna plant extracts on ethanol-induced gastric ulcer in adult Wistar rats

Ofusori

Moodley

Jonnalagadda

2020

Journal of Traditional and Complementary Medicine

View full text Add to dashboard Cite

show abstract

“…Gac fruit has a wide range of biological functions, including antioxidant, anti-cancer, anti-inflammatory, antimicrobial, and immunomodulatory properties. Thanks to such remarkable properties, gac fruits and their products attract the attention of scientists of various specialties [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%