Gadofosveset trisodium in the investigation of focal liver lesions in noncirrhotic liver: Early experience

Milot, Laurent; Haider, Masoom A.; Foster, Lynette; McGregor, Cailtin; Law, Calvin

doi:10.1002/jmri.23650

Cited by 14 publications

(22 citation statements)

References 10 publications

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“…For all target lesions, the contrast-to-noise ratio (CNR) on 10-min delayed phase was calculated using previously described methods [9]. At the axial level where the lesion was the largest, a round region of interest (ROI) most closely approximating the entire tumour was drawn to determine the lesion’s mean signal intensity (SI).…”

Section: Methodsmentioning

confidence: 99%

Late gadolinium enhancement of colorectal liver metastases post-chemotherapy is associated with tumour fibrosis and overall survival post-hepatectomy

et al. 2018

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PurposeTo determine whether late gadolinium MRI enhancement of colorectal liver metastases (CRCLM) post-chemotherapy is associated with tumour fibrosis and survival post-hepatectomy.Materials and methodsThe institutional review board approved this retrospective cohort study and waived the requirement for informed consent. A cohort of 121 surgical patients who received preoperative MRI after chemotherapy between 2006-2012 was included in this study. Target tumour enhancement (TTE), defined as the mean contrast-to-noise ratio of up to two target lesions on late-phase gadobutrol-enhanced MRI, was determined by two independent raters. The average TTE was correlated with tumour fibrosis on post-hepatectomy specimens using Spearman correlation and with survival post-hepatectomy using Kaplan-Meier and Cox regression. Inter-rater reliability was determined using relative intra-class correlation coefficients.ResultsIn the surgical cohort (mean age: 63.0 years; male: 58%), TTE was associated with tumour fibrosis (r = 0.43, p < 0.001). Strong TTE was associated with improved survival compared to weak TTE (3-year survival: 88.4% vs. 58.8%, p = 0.003) with a hazard ratio of 0.32 (95% CI: 0.14-0.75, p = 0.008), after taking into account known prognostic variables. Inter-rater reliability was very good with a relative intraclass correlation of 0.84 (95% CI: 0.77-0.89).ConclusionLate gadolinium MRI enhancement of CRCLM post-chemotherapy is associated with tumour fibrosis and survival.Key Points • MRI enhancement of colorectal liver metastases is associated with survival post-hepatectomy • MRI enhancement of chemotherapy-treated colorectal liver metastases correlates with tumour fibrosis • Measuring late MRI enhancement using target tumour enhancement is reliable

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Section: Methodsmentioning

confidence: 99%

Late gadolinium enhancement of colorectal liver metastases post-chemotherapy is associated with tumour fibrosis and overall survival post-hepatectomy

et al. 2018

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“…Only four cases (from two studies) on the use of MRI with intravascular contrast agents to image colorectal liver metastases has been described in the literature, with similar findings (6,7). Two other studies have described the use of combined gadofosveset and gadoxetic acid, which suggest this may be helpful for improved detection of liver metastases (8,9).…”

Section: Discussionmentioning

confidence: 97%

“…It is thought that there would be minimal late retention of contrast into colorectal liver metastases with intravascular contrast agents since the contrast remains within the intravascular space (6,7).…”

Section: Discussionmentioning

confidence: 99%

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Gadofosveset-enhanced magnetic resonance imaging as a problem-solving tool for diagnosing colorectal liver metastases: a case report

Cheung

Karanicolas

Coburn

et al. 2018

Quant. Imaging Med. Surg.

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Due to significant improvements in morbidity and mortality, surgery with curative intent is now the standard of care for patients with colorectal liver metastases who are surgical candidates. As a result, highly accurate preoperative per-lesion diagnosis is crucial. However, in some instances, this remains limited with standard techniques, including magnetic resonance imaging (MRI) with conventional contrast agents.Delayed retention of contrast of fibrotic liver metastases on MRI with extracellular contrast agents may mimic the late retention of contrast in hemangiomas and represent a diagnostic pitfall that limits diagnosis.Early preliminary work suggests that this imaging pitfall may not be seen on MRI with intravascular contrast agents (e.g., gadofosveset). This case report describes a surgical patient with colorectal liver metastases where gadofosveset-enhanced liver MRI was helpful in determining patient management.

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“…Ablavar chelates gadolinium intravenously and binds reversibly to serum albumin thereby enabling a prolonged optimal intravascular simultaneous enhancement of both the arterial and venous system as the flow transitions from the arterial phase to the venous phase (33)(34)(35). In particular the lesion's anatomic relationship to adjacent structures can be defined and is consequently a vital aide in planning of therapy.…”

Section: Mrimentioning

confidence: 99%

Venous malformations: clinical diagnosis and treatment

Behravesh

Yakes²,

Gupta

et al. 2016

Cardiovasc. Diagn. Ther.

192

150

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Venous malformation (VM) is the most common type of congenital vascular malformation (CVM). They are present at birth and are often symptomatic, causing morbidity and pain. VMs can be challenging to diagnose and are often confused with hemangioma in terminology as well as with imaging. An accurate clinical history and cross-sectional imaging are critical for diagnosis and for devising management. This manuscript will review imaging approaches to diagnosing VMs and current treatment strategies.

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Gadofosveset trisodium in the investigation of focal liver lesions in noncirrhotic liver: Early experience

Abstract: Hemangiomas accumulate Gdfos on delayed phase and metastases do not, a key additional differentiating feature. Liver imaging with Gdfos may improve characterization of liver lesions.

Cited by 14 publications

References 10 publications

Late gadolinium enhancement of colorectal liver metastases post-chemotherapy is associated with tumour fibrosis and overall survival post-hepatectomy

Late gadolinium enhancement of colorectal liver metastases post-chemotherapy is associated with tumour fibrosis and overall survival post-hepatectomy

Gadofosveset-enhanced magnetic resonance imaging as a problem-solving tool for diagnosing colorectal liver metastases: a case report

Venous malformations: clinical diagnosis and treatment

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