Gadolinium-doped carbon quantum dots loaded magnetite nanoparticles as a bimodal nanoprobe for both fluorescence and magnetic resonance imaging

Huang, Yan; Li, Long; Zhang, Donghui; Gan, Liping; Zhao, Pei; Zhang, Yinfeng; Zhang, Qi; Hua, Mingqing; Jia, Chunman

doi:10.1016/j.mri.2020.02.003

Cited by 46 publications

(20 citation statements)

References 50 publications

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“…Huanga and co-authors [ 124 ] reported a new strategy for the fabrication of a single hybrid nanostructure consisting of carbon quantum dots (CQDs), Gd(III) ions, and Fe 3 O 4 nanoparticles as a new bimodal imaging agent and demonstrated that the nanocomposite could emit fluorescence; thus, it had potential for reliable fluorescence imaging. The r 1 and r 2 relaxivities of the nanocomposite were measured to be 5.16 and 115.6 mM −1 s −1 , which nominated the nanocomposite as a suitable T 1 -T 2 contrast agent.…”

Section: Application Of Magnetic Ferrofluids In Optics and Nanophotonicsmentioning

confidence: 99%

Magnetite Nanoparticles: Synthesis and Applications in Optics and Nanophotonics

et al. 2022

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Magnetite nanoparticles with different surface coverages are of great interest for many applications due to their intrinsic magnetic properties, nanometer size, and definite surface morphology. Magnetite nanoparticles are widely used for different medical-biological applications while their usage in optics is not as widespread. In recent years, nanomagnetite suspensions, so-called magnetic ferrofluids, are applied in optics due to their magneto-optical properties. This review gives an overview of nanomagnetite synthesis and its properties. In addition, the preparation and application of magnetic nanofluids in optics, nanophotonics, and magnetic imaging are described.

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Section: Application Of Magnetic Ferrofluids In Optics and Nanophotonicsmentioning

confidence: 99%

Magnetite Nanoparticles: Synthesis and Applications in Optics and Nanophotonics

et al. 2022

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“…Iron-doped CDs were synthesized by introducing iron benzoate [ 69 ], FeCl 3 [ 70 ], or Fe-gluconate [ 71 ] as precursors. Moreover, other metal-doped CQDs have also been synthesized and applied for different applications, such as manganese-doped CDs [ 72 ], Zn-doped CDs [ 73 ], cobalt(II)-doped CDs [ 74 ], gadolinium-doped CDs [ 75 ], europium-doped CDs [ 76 ], Ce doped-CDs [ 77 ], terbium-doped CDs [ 78 ], europium-doped CDs [ 79 ], ruthenium-doped CDs [ 80 ], and germanium-doped CDs [ 81 ].…”

Section: Preparation and Modification Of Cdsmentioning

confidence: 99%

Recent Advances in Synthesis, Modification, Characterization, and Applications of Carbon Dots

Pundi

Chang

2022

Polymers

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Although there is significant progress in the research of carbon dots (CDs), some challenges such as difficulty in large-scale synthesis, complicated purification, low quantum yield, ambiguity in structure-property correlation, electronic structures, and photophysics are still major obstacles that hinder the commercial use of CDs. Recent advances in synthesis, modification, characterization, and applications of CDs are summarized in this review. We illustrate some examples to correlate process parameters, structures, compositions, properties, and performances of CDs-based materials. The advances in the synthesis approach, purification methods, and modification/doping methods for the synthesis of CDs are also presented. Moreover, some examples of the kilogram-scale fabrication of CDs are given. The properties and performance of CDs can be tuned by some synthesis parameters, such as the incubation time and precursor ratio, the laser pulse width, and the average molar mass of the polymeric precursor. Surface passivation also has a significant influence on the particle sizes of CDs. Moreover, some factors affect the properties and performance of CDs, such as the polarity-sensitive fluorescence effect and concentration-dependent multicolor luminescence, together with the size and surface states of CDs. The synchrotron near-edge X-ray absorption fine structure (NEXAFS) test has been proved to be a useful tool to explore the correlation among structural features, photophysics, and emission performance of CDs. Recent advances of CDs in bioimaging, sensing, therapy, energy, fertilizer, separation, security authentication, food packing, flame retardant, and co-catalyst for environmental remediation applications were reviewed in this article. Furthermore, the roles of CDs, doped CDs, and their composites in these applications were also demonstrated.

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“…The anti-PSA specific DNA aptamer Multimodal bioimaging, drug release, PDT, biosensing [54] Semiconductor nanoparticles (QDs) Inorganic The MUC1 aptamer-(CGA) 7 /S3.1/ S2.2 Bioimaging, biosensing, and drug delivery [55] Plasmonic nanocarriers (gold nanospheres, nanorods) Inorganic A9 Sgc8c CSC1/CSC13 Bioimaging [56], PTT [57,58], plasmonic sensors, gene therapy actively targeted nanoprobes [85,86]. Once entering the body, these multifunctional molecular probes conjugated with related tumor-targeted biomolecules are expected to be directly located at the target sites through specific binding, such as antigen-antibody reactions [87] and ligandreceptor reactions [88], thereby inducing changes in the local MR signal (Figure 3).…”

Section: Silica-based Nanoparticles Inorganicmentioning

confidence: 99%

The Aptamer Functionalized Nanocomposite Used for Prostate Cancer Diagnosis and Therapy

Feng

Zhu

Wang

et al. 2022

Journal of Nanomaterials

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Prostate cancer is one of the major malignancies that threaten men’s health all over the world. Due to the lack of specific symptoms and signs in the early stage, as well as the limitations of existing detection methods, it is difficult to achieve early diagnosis for prostate cancer. As short single-stranded oligonucleotides (DNA or RNA) with specific 3D structure which can be produced using an in vitro selection process termed systematic evolution of ligands by exponential enrichment (SELEX), aptamers can specifically bind to the corresponding targets. They have become a class of novel targeting ligand for accurate diagnosis and effective treatment of cancer. Owing to distinctive physicochemical features, and some other special properties such as easy modifiability, good biocompatibility, being easily coupled with other ligands, nanomaterials are extensively used in biological medical field research. Enlighteningly, the combination of aptamers with nanomaterials, including metal nanoparticles, nanosilica, quantum dots, and carbon nanomaterials, can enhance the ability of nanomaterials to recognize tumor cells, which is beneficial to overcome the shortcomings such as low sensitivity in early detection and lack of specificity of traditional antineoplastic drugs, thus, clinically helpful to improve the early metaphase diagnosis rate, providing a technical guarantee for the “personalized treatment” strategy for prostate cancer. Herein, we mainly review the basic and applied research of aptamer functionalized nanocomposite in prostate cancer diagnosis and treatment, including biosensing, bioimaging, and cancer therapy, hoping to provide new ideas for prostate cancer diagnosis and treatment.

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Gadolinium-doped carbon quantum dots loaded magnetite nanoparticles as a bimodal nanoprobe for both fluorescence and magnetic resonance imaging

Cited by 46 publications

References 50 publications

Magnetite Nanoparticles: Synthesis and Applications in Optics and Nanophotonics

Magnetite Nanoparticles: Synthesis and Applications in Optics and Nanophotonics

Recent Advances in Synthesis, Modification, Characterization, and Applications of Carbon Dots

The Aptamer Functionalized Nanocomposite Used for Prostate Cancer Diagnosis and Therapy

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