Gadoxetate disodium-enhanced MR imaging: Differentiation between early-enhancing non-tumorous lesions and hypervascular hepatocellular carcinomas

Goshima, Satoshi; Kanematsu, Masayuki; Watanabe, Hidenobu; Kondo, Hiroshi; Mizuno, Nozomi; Kawada, Hiroshi; Shiratori, Yoshimune; Onozuka, Minoru; Moriyama, Noriyuki; Bae, Kyongtae T.

doi:10.1016/j.ejrad.2011.04.041

Cited by 14 publications

(12 citation statements)

References 20 publications

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“…This is in contrast to the recommendations of the consensus report of the Second International Forum for Liver MRI published in 2009 (23). The use of faster, higher spatial resolution 3D pulse sequences is well supported by more recent work from around the world (20,(24)(25)(26)(27)(28). We also noted that although this technique was useful at both 3T and 1.5T, the increased projected energy deposition at 3T (SAR) caused the MR scanner console to reduce the FA of the pulse sequence in four of seven cases performed at 3T in our initial review, a phenomenon that has been previously described (20).…”

Section: Discussioncontrasting

confidence: 51%

Liver MRI in the hepatocyte phase with gadolinium‐EOB‐DTPA: Does increasing the flip angle improve conspicuity and detection rate of hypointense lesions?

Bashir

Husarik

Ziemlewicz

et al. 2011

Magnetic Resonance Imaging

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Purpose: To compare conspicuity and detection rate of hypointense lesions on T1-weighted (T1w) gradient echo (GRE) sequences with low and high flip angles (FA) in hepatocyte phase magnetic resonance imaging (MRI) using gadoxetate disodium. Materials and Methods:This Health Insurance Portability and Accountability Act (HIPAA)-compliant study was Institutional Review Board (IRB)-approved. The study population consisted of patients with hypointense liver lesions undergoing MRI with gadoxetate disodium, with hepatocyte-phase fat suppressed 3D T1w GRE sequences at both low (10)(11)(12) ) and high (30-35 ) FA. Contrast-tonoise ratios (CNRs) were calculated for liver parenchyma vs. large lesions and common bile duct (CBD) vs. liver. Three radiologists each assigned a conspicuity score (CS) for each lesion detected at low or high FA. Paired Student's t-tests compared the lesion detection (LD) rate using only the hepatocyte phase data set compared with the entire MRI examination, and CS for low and high FA.Results: In all, 57 large and 70 small lesions were identified in 18 patients. Average LD and CS were significantly greater at high FA versus low FA overall (LD 89.0% vs. 79.5%; CS 2.8 vs. 2.2; P < 0.05) and for small lesions (81.4% vs. 65.7%; 2.5 vs. 1.8; P < 0.05). Average liver-tolesion CNR for large lesions and CBD-to-liver CNR was significantly greater at high FA (P < 0.05). Conclusion:Increasing the FA in hepatocyte phase MRI with gadoxetate disodium improves hypointense lesion detection and conspicuity, particularly for small lesions.

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Section: Discussioncontrasting

confidence: 51%

Liver MRI in the hepatocyte phase with gadolinium‐EOB‐DTPA: Does increasing the flip angle improve conspicuity and detection rate of hypointense lesions?

Bashir

Husarik

Ziemlewicz

et al. 2011

Magnetic Resonance Imaging

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“…In agreement with previous studies (26, 33–35), the vast majority of benign arterial enhancing‐only nodules smaller than 2 cm in our series revealed HP iso‐hyperintensity. Differently from previous studies (36) we only observed 7 benign lesions appearing hypointense on HP which corresponded to high‐flow liver hemangiomas. In any case, the relative prevalence of benign lesions observed is not in agreement with some previous studies which showed that small arterial enhancing‐only nodules, isointense to the liver on T1‐ and T2‐weighted images, are more likely to be HCC in patients with hepatitis B‐related cirrhosis (37).…”

Section: Discussioncontrasting

confidence: 99%

Characterization of TALE genes expression during the first lineage segregation in mammalian embryos

Sonnet

Rezsöhazy

Donnay

2012

Developmental Dynamics

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Background: Three amino acid loop extension (TALE) homeodomain-containing transcription factors are generally recognized for their role in organogenesis and differentiation during embryogenesis. However, very little is known about the expression and function of Meis, Pbx, and Prep genes during early development. Results: In order to determine whether TALE proteins could contribute to the early cell fate decisions in mammalian development, this study aimed to characterize in a systematic manner the pattern of expression of all Meis, Pbx, and Prep genes from the precompaction to blastocyst stage corresponding to the first step of cell differentiation in mammals. To reveal to what extent TALE genes expression at these early stages is a conserved feature among mammals, this study was performed in parallel in the bovine and mouse models. We demonstrated the transcription and translation of TALE genes, before gastrulation in the two species. At least one member of Meis, Pbx, and Prep subfamilies was found expressed at the RNA and protein levels but different patterns of expression were observed between genes and between species, suggesting specific gene regulations. Conclusions: Taken together, these results suggest a previously unexpected involvement of these factors during the early development in mammals. Developmental Dynamics 241:1827-1839, 2012. V C 2012 Wiley Periodicals, Inc.Key words: Meis; Pbx; Prep; TALE; homeodomain proteins; preimplantation development; bovine; mouse Key findings:By a systematic approach, we demonstrated the transcription and translation of TALE genes before gastrulation during the first steps of cell differentiation in bovine and in mouse embryos. TALE genes are expressed during the first cell lineage specification in mammals. TALE proteins are present before gastrulation in mammalian morulae and blastocysts. TALE genes expression is differently regulated in mouse and bovine early embryos. TALE mRNA and protein levels are well correlated in early mammalian embryos. TALE proteins are found both in the inner cell mass and trophectoderm cells of mammalian blastocysts.

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“…In this series, the percentage of HCCs with hepatobiliary phase isohyperintensity (5/57) was low in comparison with previous studies [32], in which about 30% of HCCs revealed iso-or hyperintensity; however, the percentage of dysplastic nodules with hepatobiliary phase hypointensity (2/25) in this study is comparable to that in previous patient series evaluated after gadobenate dimeglumine injection [32]. Other recent studies [33,34] reported an even higher percentage of benign hepatocellular nodules with hepatobiliary phase hypointensity, which was probably due to the use of a different hepatospecific contrast agent (i.e., gadoxetate disodium).…”

Section: Mri Predictors Of Dysplastic Nodule In Patients With Liver Csupporting

confidence: 66%

Predictors of Dysplastic Nodule Diagnosis in Patients With Liver Cirrhosis on Unenhanced and Gadobenate Dimeglumine–Enhanced MRI With Dynamic and Hepatobiliary Phase

Quaia

Paoli²,

Pizzolato³

et al. 2013

American Journal of Roentgenology

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Gadoxetate disodium-enhanced MR imaging: Differentiation between early-enhancing non-tumorous lesions and hypervascular hepatocellular carcinomas

Cited by 14 publications

References 20 publications

Liver MRI in the hepatocyte phase with gadolinium‐EOB‐DTPA: Does increasing the flip angle improve conspicuity and detection rate of hypointense lesions?

Liver MRI in the hepatocyte phase with gadolinium‐EOB‐DTPA: Does increasing the flip angle improve conspicuity and detection rate of hypointense lesions?

Characterization of TALE genes expression during the first lineage segregation in mammalian embryos

Predictors of Dysplastic Nodule Diagnosis in Patients With Liver Cirrhosis on Unenhanced and Gadobenate Dimeglumine–Enhanced MRI With Dynamic and Hepatobiliary Phase

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