“…From a theoretical perspective (Dayan and Abbott, 2001), these forms of plasticity relate to unsupervised learning rules, i.e., the behavioral relevance of synaptic changes is not taken into account. Recently, however, it was shown that the outcome of many plasticity experiments, including STDP, depends on neuromodulation (Seol et al, 2007), in particular the presence of dopamine (Jay, 2003;Pawlak and Kerr, 2008;Wickens, 2009;Zhang et al, 2009), a neuromodulator known to encode behavioral reward signals (Schultz et al, 1997). Inspired by these findings, a number of theoretical studies have investigated the hypothesis that reward-modulated STDP could be the neuronal basis for reward learning (Seung, 2003;Xie and Seung, 2004;Farries and Fairhall, 2007;Florian, 2007;Izhikevich, 2007;Legenstein et al, 2008).…”