Galactosylated chitosan–polycaprolactone nanoparticles for hepatocyte-targeted delivery of curcumin

Zhou, Nuo; Zan, Xiaoli; Wang, Zheng; Wu, Hua; Yin, Dengke; Liao, Chunyan; Wan, Ying

doi:10.1016/j.carbpol.2013.01.014

Cited by 80 publications

(35 citation statements)

References 38 publications

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“…In this dimension, nanoscience and nanotechnology opens a very exciting window of opportunity via enabling the enhanced curcumin delivery through nanoscale carriers, carrying far lesser amount of the drug and promising a slow, targeted and gradual release. The delivery of curcumin through various nanocarriers including nanoparticles, nanoemulsions, nanosuspensions, nanofibers and many others has enabled a great deal of improvement in its systemic localized availability and the corresponding increase or amplification of its therapeutic and protective effects [49][50][51][52]. Studies have reported the enhanced benefits of curcumin delivered through nanoroutes to the extents of even 27 times [53].…”

Section: Nanotechnological Interventions To Enhance Bioavailability Omentioning

confidence: 99%

Structure-Function Elucidation of Antioxidative and Prooxidative Activities of the Polyphenolic Compound Curcumin

Malik

Mukherjee

2014

Chinese Journal of Biology

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Phenolic compounds have been very well known for their antioxidant properties, owing to their unique ability to act as free radical scavengers which, in turn, is an outstanding attribute of their unique biochemical structure. Recent accumulating lines of evidence inculcate sustainable interest and curiosity towards the chemoprotective nature of the natural polyphenolic compound curcumin (diferuloylmethane) against oxidative stress-mediated disorders. Curcumin is naturally found as a constituent of dietary spices called turmeric, extracted from the plant Curcuma longa. However, like every phenolic antioxidant, curcumin possesses a concentration and medium dependent anti-and pro-oxidant behaviour. A detailed study of the structure-function analysis and the understanding of the mode of action of curcumin as well as its chemical analogues is thus essential to understand the selective biochemical consequences of curcumin. Moreover, the presence of transition metal ions, route of administration, and localized tissue are also the vital decisive factors to determine curcumin behaviour. With this viewpoint, this paper sheds lights on the medium dependent prooxidative and antioxidative attributes of curcumin. Further, with respect to emergence of nanocarriers, a brief discussion focusing on the biochemical effect exertion of curcumin chiefly due to targeted and slow release has also been added towards the end.

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Section: Nanotechnological Interventions To Enhance Bioavailability Omentioning

confidence: 99%

Structure-Function Elucidation of Antioxidative and Prooxidative Activities of the Polyphenolic Compound Curcumin

Malik

Mukherjee

2014

Chinese Journal of Biology

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“…One of the effective targeting delivery approaches is to utilize some ligand-receptor interactions [75]. Receptor-targeted nanocarrier delivery mechanism has been shown to improve therapeutic responses both in vitro and in vivo [76].…”

Section: Ligand-receptor Chitosan Nanocarriersmentioning

confidence: 99%

“…This is due to the fact that asialoglyco-protein receptors on hepatoma cells can specifically bind with certain types of ligands containing specific terminals such as β-D-galactose and Nacetylgalactosamine residues [75].…”

Section: Ligand-receptor Chitosan Nanocarriersmentioning

confidence: 99%

Application of Chitosan-Based Nanocarriers in Tumor-Targeted Drug Delivery

et al. 2014

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Cancer is one of the major malignant diseases in the world. Current anti tumor agents are restricted during the chemotherapy due to their poor solubility in aqueous media, multidrug resistance problems, cytotoxicity, and serious side effects to healthy tissues. Development of targeted drug nanocarriers would enhance the undesirable effects of anticancer drugs and also selectively deliver them to cancerous tissues. Variety of nanocarriers such as micelles, polymeric nanoparticles, liposomes nanogels, dendrimers, and carbon nanotubes have been used for targeted delivery of anticancer agents. These nanocarriers transfer loaded drugs to desired sites through passive or active efficacy mechanisms. Chitosan and its derivatives, due to their unique properties such as hydrophilicity, biocompatibility, and biodegradability, have attracted attention to be used in nanocarriers. Grafting cancer-specific ligands onto the Chitosan nanoparticles, which leads to ligand-receptor interactions, has been successfully developed as active targeting. Chitosan-conjugated components also respond to external or internal physical and chemical stimulus in targeted tumors that is called environment triggers. In this study, mechanisms of targeted tumor deliveries via nanocarriers were explained; specifically, chitosan-based nanocarriers in tumor-targeting drug delivery were also discussed.

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“…Nevertheless, a simple blend of DOX and CUR will not be a favorable formulation for their combined use because CUR has poor aqueous solubility and low bioavailability; moreover, CUR could be rapidly cleared by the circulation. 19,20 To date, several nanocarriers involving liposomes, polyethylene glycol (PEG)-linked (PEGylated) polycaprolactone nanoparticles and chitosan/poly(butyl cyanoacrylate) nanoparticles have been used to deliver DOX and CUR together. [21][22][23][24] Although these nanocarriers have shown improved anticancer efficacy against different tumors, whether they have the potential to reverse MDR of cancer cells has not been examined.…”

mentioning

confidence: 99%

“…On the other hand, CUR is known to be hydrophobic, and in particular, it can be easily degraded under physiological conditions. 19,34 In contrast to free CUR, the loaded CUR in (DOX + CUR)-PMs would be completely protected from degradation before CUR gets into cells, and thus, more CUR molecules with sensitizing activity can finally be transferred into the cells during the endocytosis of (DOX + CUR)-PMs compared to the case of the simple combination of DOX and CUR. As a result, (DOX + CUR)-PMs result in enhanced cytotoxicity toward A549 cells, as shown in Figure 6.…”

mentioning

confidence: 99%

Nanomicelles loaded with doxorubicin and curcumin for alleviating multidrug resistance in lung cancer

Gu¹,

Li²,

Yang³

et al. 2016

IJN

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Galactosylated chitosan–polycaprolactone nanoparticles for hepatocyte-targeted delivery of curcumin

Cited by 80 publications

References 38 publications

Structure-Function Elucidation of Antioxidative and Prooxidative Activities of the Polyphenolic Compound Curcumin

Structure-Function Elucidation of Antioxidative and Prooxidative Activities of the Polyphenolic Compound Curcumin

Application of Chitosan-Based Nanocarriers in Tumor-Targeted Drug Delivery

Nanomicelles loaded with doxorubicin and curcumin for alleviating multidrug resistance in lung cancer

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