Galanin

Vrontakis, Maria; Torsello, Antonio; Friesen, Henry G.

doi:10.1007/bf03347918

Cited by 56 publications

(21 citation statements)

References 86 publications

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“…However, estrogen-independent GH and PRL producing adenoma formation was suggested in the galanin Tg mouse [46]. Galanin is widely distributed in the central and peripheral nervous system, and most abundantly in the hypothalamus where it may serve in the regulation of anterior pituitary hormones [52]. In the galanin Tg mice, the overexpression of galanin under the control of rat GH promoter was localized within GH and PRL secretory granules.…”

Section: Othersmentioning

confidence: 99%

Molecular and Histological Studies of Pituitary Tumorigenesis Using Experimental Animal Models

Minematsu

Miyai

Suzuki³

et al. 2005

Acta Histochem. Cytochem

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Pituitary tumorigenesis is a complex pathway involving numerous factors and conditions, such as hormonal stimulations, cell cycle regulators, growth factors, and transcription factors. To better understand this disease, to date, several experimental animal models have been established and analyzed. This article reviews and updates the studies on molecular mechanisms of pituitary tumorigenesis which were investigated using experimental model animals.

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Section: Othersmentioning

confidence: 99%

Molecular and Histological Studies of Pituitary Tumorigenesis Using Experimental Animal Models

Minematsu

Miyai

Suzuki³

et al. 2005

Acta Histochem. Cytochem

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“…Thus, in many ways, galanin can be considered a neural peptide. In fact, experimental findings suggest that galanin acts as a neurotransmitter or neuromodulator affecting glandular, nervous, and muscular tissues (Tatemoto et al 1983;Ahrén et al 1988;Vrontakis et al 1991;Konopka et al 1992).…”

Section: Introductionmentioning

confidence: 99%

Galanin-like immunoreactivity in the sea cucumber Holothuria glaberrima

Díaz‐Miranda

Pardo-Reoyo

Martínez

et al. 1996

Cell and Tissue Research

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Galanin, a neuropeptide of 29 amino acids originally purified from porcine small intestine, has been found in most vertebrate groups, where it is present in both the central and peripheral nervous systems. In this study, galanin-like immunoreactivity was detected in an invertebrate, the sea cucumber Holothuria glaberrima. In this organism, fibers and cells expressing galanin-like immunoreactivity were found in the enteric nerve plexuses of the esophagus, and large and small intestine, particularly in the serosal layer. Immunoreactivity was also found in the ectoneural portion of the radial nerve and in nervous elements within the body wall. Preabsorbtion tests indicated that the observed immunoreactivity was not due to cross-reactivity of the antibody with other peptides also found in the intestinal plexuses. The immunoreactivity to galanin was quantified in various tissues using radioimmunoassay and partially characterized with high performance liquid chromatography. These results show that although the holothurian peptide shows common immunological determinants with porcine galanin, it differs with regard to certain biochemical properties.

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“…Galanin, a 29-amino acid neuropeptide, is widely distributed in the peripheral and central nervous system (1). High concentrations of galanin-like immu¬ noreactivity have been reported in the median eminence (1), where specific binding sites for galanin have been demonstrated (1).…”

mentioning

confidence: 99%

Effect of galanin on basal and stimulated secretion of prolactin, gonadotropins, thyrotropin, adrenocorticotropin and cortisol in humans

Arvat

Gianotti

Ramunni

et al. 1995

European Journal of Endocrinology

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Galanin enhances both baseline and growth hormone-releasing hormone (GHRH)-induced GH secretion both in animals and in man. Although galanin has a clear influence on the secretion of other anterior pituitary hormones in animals, in man it increases prolactin (PRL) slightly but does not affect spontaneous thyrotropin (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH) or adrenocorticotropin (ACTH) secretion. The aim of our study was to verify the effect of galanin on basal and releasing hormone-stimulated release of gonadotropins, PRL, TSH, ACTH and cortisol secretion. As GH release has been shown to be inhibited by corticotropin-releasing hormone (CRH), we also studied the effect of CRH on galanin-stimulated GH increase. The effect of porcine galanin (15 micrograms/kg iv infused in 60 min) alone and in combination with thyrotropin-releasing hormone (TRH, 200 micrograms iv bolus), CRH (100 micrograms iv bolus) and gonadotropin-releasing hormone (GnRH, 100 micrograms iv bolus) on GH, PRL, TSH, ACTH, cortisol, FSH and LH secretion in seven normal young women (aged 25-30 years) was studied. Galanin infusion caused an increase in serum GH levels (p < 0.02) but failed to modify significantly the spontaneous PRL, LH, FSH, TSH, ACTH and cortisol secretion. The combined administration of TRH, GnRH and CRH caused a significant increase in PRL (p < 0.02), LH (p < 0.02), FSH (p < 0.02), TSH (p < 0.02), ACTH (p < 0.02) and cortisol (p < 0.05), but not in GH levels.(ABSTRACT TRUNCATED AT 250 WORDS)

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Galanin

Cited by 56 publications

References 86 publications

Molecular and Histological Studies of Pituitary Tumorigenesis Using Experimental Animal Models

Molecular and Histological Studies of Pituitary Tumorigenesis Using Experimental Animal Models

Galanin-like immunoreactivity in the sea cucumber Holothuria glaberrima

Effect of galanin on basal and stimulated secretion of prolactin, gonadotropins, thyrotropin, adrenocorticotropin and cortisol in humans

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