Galanin and its receptors: A novel strategy for appetite control and obesity therapy

Physiology, Signaling, and Pharmacology of Galanin Peptides and Receptors: Three Decades of Emerging Diversity

“…Importantly, a summary of much of the early data is available in a previous review and in a series of chapters in a more recent multiauthor monograph (Hökfelt and Tatemoto, 2010). There have also been several more recent focused reviews of particular aspects of galanin actions (e.g., Fang et al, 2012a;Webling et al, 2012). However, the following sections provide a brief review of galanin actions in some major central processes, based largely on data from rats or from normal and transgenic mice.…”

“…For example, central administration of galanin increases food and ethanol consumption (Leibowitz et al, 2003), and galanin-OE mice display an increased intake of dietary fat and ethanol (Karatayev et al, 2009). Indeed, the actions of central and peripheral galanin and its receptors in the regulation of metabolism, obesity, and appetite, including galanin receptor-linked mechanisms in experimental obesity, were recently reviewed in detail (Fang et al, 2012a), with the authors recommending development of GAL 1 antagonism as a novel antiobesity strategy. However, in early clinical studies, there was no strong association reported between GAL or GAL 1 genetic variants and obesity or dietary fat intake in obese children and adolescents (Schauble et al, 2005) and no evidence for a GAL 2 linkage to obesity (Sutton et al, 2006) (Table 6).…”

The regulative effect of galanin family members on link of energy metabolism and reproduction

“…Firstly, administration of galanin or its agonist, galanin (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16), into paraventricular nucleus (PVN) and central nucleus of the amygdala of animals promoted food intake and weight gain when food was plentiful [29,44,92,100,107,151,183].…”

Effect of endogenous galanin on glucose transporter 4 expression in cardiac muscle of type 2 diabetic rats

“…Recently, there is increasing evidence focused on the important role of galanin as a critical factor to reduce insulin resistance and to benefit glucose uptake in insulin-independent diabetes [9]. Firstly, galanin may accelerate food intake, body weight and adiposity of subjects [10]. I.c.v.…”