2011
DOI: 10.1016/j.ygcen.2011.05.011
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Galanin antagonist increases insulin resistance by reducing glucose transporter 4 effect in adipocytes of rats

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Cited by 48 publications
(39 citation statements)
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“…The obese phenotype of these mice is associated with reduced energy expenditure and insulin resistance [28] . These findings support our previous findings that endogenous galanin contributes to decreased insulin resistance and improved insulin sensitivity in rats [29][30][31] .…”
Section: Effects Of Galanin On Food Intake and Energy Expendituresupporting
confidence: 93%
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“…The obese phenotype of these mice is associated with reduced energy expenditure and insulin resistance [28] . These findings support our previous findings that endogenous galanin contributes to decreased insulin resistance and improved insulin sensitivity in rats [29][30][31] .…”
Section: Effects Of Galanin On Food Intake and Energy Expendituresupporting
confidence: 93%
“…Interestingly, galanin also promotes insulin sensitivity [28,29] . Most recently, our studies in skeletal muscle and adipocytes preliminarily verified the hypothesis that endogenous galanin notably enhances insulin sensitivity and reduces insulin resistance [30,31] . As yet it is unknown which of the three receptor subtypes is/are the most effective in enhancing insulin sensitivity.…”
Section: Resultssupporting
confidence: 67%
“…injection of 3% amobarbital sodium (50 mg/kg) individualized to each subject's body weight and subjected to hyperglycemic clamp tests, as previously described (Guo et al 2011). Insulin at a constant rate of 2 mU/kg per min was infused through a catheter into the jugular vein until the end of the test.…”
Section: Hyperinsulinemic-euglycemic Clamp and 2dg Testsmentioning
confidence: 99%
“…As a versatile regulator, this peptide may ameliorate insulin resistance via boosting glucose transporter 4 (GLUT4) translocation, leading to glucose uptake into adipose and muscle tissues (Guo et al 2011, He et al 2011. Recent studies have provided compelling clues about the relationship between galanin and insulin sensitivity.…”
Section: Introductionmentioning
confidence: 99%
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