Galanin-Like Peptide: Neural Regulator of Energy Homeostasis and Reproduction

Lawrence, Catherine B.; Fraley, Gregory S.

doi:10.1007/978-3-0346-0228-0_18

Cited by 3 publications

(1 citation statement)

References 78 publications

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“…Other peptides known to interact with galanin receptors could potentially adopt a similar mode of binding. Galanin-like peptide (GALP) (Lawrence and Fraley 2010), for instance, is twice as long but contains fragment (33 -46) identical with galanin. Ligand docking attempts to dock longer galanin peptides to the receptors failed as the proposed helical model of the N-terminal region of galanin was not able to enter the binding pocket in any of the receptors, which questions validity of the previously proposed helical galanin structure (Morris et al 1995, Ohman et al 1998.…”

Section: Discussionmentioning

confidence: 99%

Ligand binding properties of human galanin receptors

Jurkowski

Elofsson

2012

Molecular Membrane Biology

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This is an accepted version of a paper published in Molecular membrane biology. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination.Citation for the published paper: Jurkowski, W., Yazdi, S., Elofsson, A. (2013) AbstractThe galanin receptor family comprises of three members, GalR1, GalR2 and GalR3, all belonging to the G-protein-couple receptor superfamily. All three receptors bind the peptide hormone galanin, but show distinctly di erent binding properties to other molecules and e ects on intracellular signaling. To gain insight on the molecular basis of receptor subtype speci ficity, we have generated a three-dimensional model for each of the galanin receptors based on its homologs in the same family. We found significant di erences in the organization of the binding pockets among the three types of receptors, which might be the key for specific molecular recognition o igands. Through docking o ragments of the galanin peptide and a number o igands, we investigated the involvement of transmembrane and loop residues in ligand interaction.

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Section: Discussionmentioning

confidence: 99%

Ligand binding properties of human galanin receptors

Jurkowski

Elofsson

2012

Molecular Membrane Biology

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The galanin peptide family in inflammation

Lang

Kofler

2011

Neuropeptides

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Development of a new method of intranasal injection of GALP regarding clinical application to obese people

Takenoya¹,

Hirako²,

Kageyama³

et al. 2013

Official Journal of the Japan Society of Drug Delivery System

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S D D 星薬科大学・薬学部・運動生理学＊1) 昭和大学・医学部・顕微解剖学部門＊２) 桐生大学・医療保健学部・栄養学科＊3) 昭和大学・歯学部・口腔解剖学＊4) 竹ノ谷文子＊1,2) ・平子哲史＊2) ・影山晴秋＊3) ・野中直子＊4) ・塩田清二＊2) GALP による抗肥満の臨床応用に向けた点鼻投与法の開発 Development of a new method of intranasal injection of GALP regarding clinical application to obese people Galanin-like peptide (GALP) was discovered in the porcine hypothalamus in 1999 and it was found to be a 60 amino-acid peptide. Administration of GALP is well known to decrease food intake and body weight. In addition, it is also shown to increase core body temperature and energy metabolism after intraventricular infusion. Therefore, GALP may be a potential therapeutic medicine to be sued for the treatment of life-related diseases. This review summarizes the current evidence regarding the function of GALP, particularly in relation to feeding and energy metabolism. Moreover, intranasal administration of GALP is an effective route for delivery to the brain. We have examined the effect of GALP on food intake, body weight and energy metabolism after intranasal infusion which is a clinically viable route of delivery. We will present here that GALP may be used for obese people and also be helpful to overcome lifestyle related diseases in the near future.

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Galanin-Like Peptide: Neural Regulator of Energy Homeostasis and Reproduction

Cited by 3 publications

References 78 publications

Ligand binding properties of human galanin receptors

Ligand binding properties of human galanin receptors

The galanin peptide family in inflammation

Development of a new method of intranasal injection of GALP regarding clinical application to obese people

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