Galectin‐7 as a potential predictive marker of chemo‐ and/or radio‐therapy resistance in oral squamous cell carcinoma

Matsukawa, Sho; Morita, Keiichi; Negishi, Ayako; Harada, Hiroyuki; Nakajima, Yusuke; Shiba, Hiroaki; Tomioka, Hirofumi; Tanaka, Kimihiro; Ono, M.; Yamada, Tesshi; Omura, Ken

doi:10.1002/cam4.195

Cited by 27 publications

(24 citation statements)

References 30 publications

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“…Consistence with reports in breast, ovarian and oral squamous cell carcinoma [19, 22, 23], elevated galectin-7 expression acted as a reverse predictive factor in non-metastasis ccRCC patients. This finding may result from the function of galectin-7 in enhancing tumor cells aggressiveness and inducing chemo-resistance [19].…”

Section: Discussionsupporting

confidence: 62%

High expression of galectin-7 associates with poor overall survival in patients with non-metastatic clear-cell renal cell carcinoma

et al. 2016

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BackgroundGalectin-7, has a controversial role in tumor progression, can either suppress tumor growth or induce chemoresistance depends on different tumor histology types. The aim was to appraise Galectin-7 expression on the overall survival (OS) of patients with non-metastatic clear cell renal cell carcinoma (ccRCC) following surgery.ResultsHigh galectin-7 expression was specifically correlated with necrosis (P = 0.015). Multivariate analysis confirmed galectin-7 as an independent prognosticator for OS (P = 0.005). High galectin-7 expression suggested poor OS (P < 0.001), particularly with UISS intermediate and high score groups. Notably, the predictive accuracy of the traditional prognostic scores was improved when combined with galectin-7 expression.Materials and MethodsWe retrospectively enrolled 416 patients who underwent nephrectomy at a single institute between 2008 and 2009 and detected their intratumor galectin-7 expression by immunohistochemistry. Kaplan-Meier method was conducted to plot survival curves and multivariate cox regression analysis for potential independent prognostic factors on OS. A nomogram was constructed with concordance index (C-index) and Akaike's Information Criteria (AIC) to appraise prognostic accuracy of different models.ConclusionsHigh galectin-7 expression is an independent adverse predictor for survival. Evaluation of galectin-7 could help guide postsurgical management for non-metastatic ccRCC patients.

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Section: Discussionsupporting

confidence: 62%

High expression of galectin-7 associates with poor overall survival in patients with non-metastatic clear-cell renal cell carcinoma

et al. 2016

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“…Matsukawa et al (18) reported previously that adenoviral delivery of the galectin-7 gene may induce modest apoptosis and reduce the viability of human OSCC HSC3 cells.…”

Section: Discussionmentioning

confidence: 99%

Galectin-7 promotes the invasiveness of human oral squamous cell carcinoma cells via activation of ERK and JNK signaling

Guo¹,

Li²

2017

Oncology Letters

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Abstract. Galectin-7 is a member of the β-galactoside-binding protein family, and is highly expressed in oral squamous cell carcinoma (OSCC). The aim of the present study was to investigate the effects of manipulating galectin-7 expression on the biological phenotype of human OSCC cells and the associated molecular mechanisms. Knockdown of endogenous galectin-7 via small interfering RNA (siRNA) was performed and cell proliferation, apoptosis, migration, and invasion were subsequently assessed. The data indicated that galectin-7 silencing had no impact on the proliferation or apoptosis of OSCC cells. However, compared with non-transfected cells, percentage wound closure was significantly lower in galectin-7-silenced cells following 24 h incubation, indicating decreased cell migration. Furthermore, Matrigel invasion assays demonstrated that galectin-7 knockdown significantly reduced the number of invaded cells, compared with the number in non-transfected cells. Western blot analysis indicated that galectin-7 overexpression resulted in a significant increase in the expression of the proteins matrix metalloproteinase (MMP)-2 and MMP-9. The invasive abilities of cells overexpressing galectin-7 significantly decreased following co-transfection with MMP-2-or MMP-9-specific siRNA. Increasing galectin-7 expression significantly enhanced the phosphorylation of extracellular signal-related kinase (ERK) 1/2 and c-Jun N-terminal kinase (JNK) 1/2. Pharmacological inhibition of ERK or JNK activity significantly suppressed the invasiveness of galectin-7-overexpressing cells and abrogated the upregulation of MMP-2 and MMP-9. Taken together, the results of the current study provide novel evidence for the pro-invasive activity of galectin-7 in OSCC cells, which is associated with activation of ERK and JNK signaling and the induction of MMP-2 and MMP-9.

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“…Recent study on oral SCC showed that galectin-7 can act as potential predictive marker of chemo/radio therapy resistance in this cancer. Oral SCC cell line showed decreased cell viability with elevated expression of galectin-7 (Matsukawa et al, 2014).…”

Section: 455 Expression and Roles Of Galectin-7 In Different Types Omentioning

confidence: 99%

Roles of Galectin-7 in Cancer

Kaur

Kaur²,

Kamboj³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Galectins are β-galactoside binding lectins that contain one or more carbohydrate recognition domains. As a consequence of sugar-binding properties, galectins exhibit a variety of interactions with glycoproteins, thus playing important roles in various pathological processes. A number of studies have shown roles of galectins in cancer. Galectin-7 is a prototype member of the galectin family implicated in epithelial stratification and cell migration. It can act as a potent dual regulator in different types of cancer. Galectin-7 may contribute either to neoplastic transformation and tumour progression through regulation of cell growth, cell cycle, angiogenesis, apoptosis and cell migration or may have a protective effect in cancer depending on the tissue type. A perusal of the literature indicates particular roles of galectin-7 in carcinomas and melanomas, while contributions await greater exploration in other types of cancers including sarcomas and leukemia. This review collectively summarizes available literature on expression and roles of galectin-7 in different cancers.

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Galectin‐7 as a potential predictive marker of chemo‐ and/or radio‐therapy resistance in oral squamous cell carcinoma

Cited by 27 publications

References 30 publications

High expression of galectin-7 associates with poor overall survival in patients with non-metastatic clear-cell renal cell carcinoma

High expression of galectin-7 associates with poor overall survival in patients with non-metastatic clear-cell renal cell carcinoma

Galectin-7 promotes the invasiveness of human oral squamous cell carcinoma cells via activation of ERK and JNK signaling

Roles of Galectin-7 in Cancer

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