We construct firstly the complete list of five quantum deformations of D = 4 complex homogeneous orthogonal Lie algebra o(4; C) ∼ = o(3; C) ⊕ o(3; C), describing quantum rotational symmetries of four-dimensional complex space-time, in particular we provide the corresponding universal quantum R-matrices. Further applying four possible reality conditions we obtain all sixteen Hopf-algebraic quantum deformations for the real forms of o(4; C): Euclidean o(4), Lorentz o(3, 1), Kleinian o(2, 2) and quaternionic o ⋆ (4). For o(3, 1) we only recall well-known results obtained previously by the authors, but for other real Lie algebras (Euclidean, Kleinian, quaternionic) as well as for the complex Lie algebra o(4; C) we present new results.