Gall bladder: The metabolic orchestrator

Li, Qi; Tian, Yu; Chen, Yongsheng

doi:10.1002/dmrr.3140

Cited by 16 publications

(11 citation statements)

References 76 publications

(91 reference statements)

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“…The possibility of correlation between cholecystectomy and LF or LC is further supported by the findings from the present study. After cholecystectomy, changes in bile flow and concentration of bile acid in the bile duct ( 33 ) might occur, which may cause chronic cholestasis, NAFLD and metabolic syndrome ( 10 , 34 – 36 ). Interestingly, the study showed that participants with cholecystectomy for over 14 years had a higher incidence of LF than those <14 years ( Supplementary Table 4 ).…”

Section: Discussionmentioning

confidence: 99%

“…Cholecystectomy is among the most common operations performed worldwide, with 750,000–1,000,000 procedures conducted in the United States, annually ( 42 ). Considering the early and delayed complications associated with cholecystectomy, it would be important to reassess the function and importance of the gallbladder ( 34 ). Strict surgical indications should also be implemented to reduce unnecessary cholecystectomy ( 43 ), given that preoperative evaluation of abdominal pain through gastroduodenoscopy was reported to be able to prevent 3.8% of cholecystectomies ( 44 ).…”

Section: Discussionmentioning

confidence: 99%

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Association of Cholecystectomy With Liver Fibrosis and Cirrhosis Among Adults in the USA: A Population-Based Propensity Score-Matched Study

Xie

Tan

et al. 2021

Front. Med.

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Background and Aims: Cholecystectomy is the “gold standard” for treating diseases of the gallbladder. In addition, non-alcoholic fatty liver disease (NAFLD), liver fibrosis or cirrhosis, are major causes of morbidity and mortality across the world. However, the association between cholecystectomy and these diseases is still unclear. We assessed the association among US adults and examined the possible risk factors.Methods: This cross-sectional study used data from 2017 to 2018 National Health and Nutrition Examination Survey, a population-based nationally representative sample of US. Liver fibrosis and cirrhosis were defined by median stiffness, which was assessed by transient elastography. Furthermore, patients who had undergone cholecystectomy were identified based on the questionnaire. In addition, Propensity Score Matching (PSM, 1:1) was performed based on gender, age, body mass index (BMI) and diabetes.Results: Of the 4,497 included participants, cholecystectomy was associated with 60.0% higher risk of liver fibrosis (OR:1.600;95% CI:1.278–2.002), and 73.3% higher risk of liver cirrhosis (OR:1.733, 95% CI:1.076–2.792). After PSM based on age, gender, BMI group and history of diabetes, cholecystectomy was associated with 139.3% higher risk of liver fibrosis (OR: 2.393;95% CI: 1.738–3.297), and 228.7% higher risk of liver cirrhosis (OR: 3.287, 95% CI: 1.496–7.218).Conclusions: The present study showed that cholecystectomy is positively associated with liver fibrosis and cirrhosis in US adults. The discovery of these risk factors therefore provides new insights on the prevention of NAFLD, liver fibrosis, and cirrhosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association of Cholecystectomy With Liver Fibrosis and Cirrhosis Among Adults in the USA: A Population-Based Propensity Score-Matched Study

Xie

Tan

et al. 2021

Front. Med.

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“…Another cause suggested that excessive amounts of bile acids in the colonic lumen could be irritating and toxic to the colonic epithelium [ 51 ]. Bile acid synthesis has a sharp rise after meals, and the peak occurs from 09:00 to 10:00 p.m. [ 52 ]. Hence, a higher calcium intake at dinner may be more likely to induce the conversion of bile acids to insoluble calcium compounds, thereby reducing the adverse effect of bile acids on the colonic epithelium and decreasing the incidence of gastrointestinal tumors.…”

Section: Discussionmentioning

confidence: 99%

The association of minerals intake in three meals with cancer and all-cause mortality: the U.S. National Health and Nutrition Examination Survey, 2003–2014

Wei

et al. 2021

BMC Cancer

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Background Intake time of diet has recently been demonstrated to be associated with the internal clock and circadian pattern. However, whether and how the intake time of minerals would influence the natural course of cancer was largely unknown. Methods This study aimed to assess the association of mineral intake at different periods with cancer and all-cause mortality. A total of 27,455 participants aged 18–85 years old in the National Health and Nutrition Examination Survey were recruited. The main exposures were the mineral intakes in the morning, afternoon and evening, which were categorized into quintiles, respectively. The main outcomes were mortality of cancer and all causes. Results During the 178,182 person-years of follow-up, 2680 deaths, including 601 deaths due to cancer, were documented. After adjusting for potential confounders, compared to the participants who were in the lowest quintile(quintile-1) of mineral intakes at dinner, the participants in the highest quintile intake(quintile-5) of dietary potassium, calcium and magnesium had lower mortality risks of cancer (HRpotassium = 0.72, 95% CI:0.55–0.94, P for trend = 0.023; HRcalcium = 0.74, 95% CI:0.57–0.98, P for trend = 0.05; HRmagnesium = 0.75, 95% CI:0.56–0.99, P for trend = 0.037) and all-cause (HRpotassium = 0.83, 95% CI:0.73–0.94, P for trend = 0.012; HRcalcium = 0.87, 95% CI:0.76–0.99, P for trend = 0.025; HRmagnesium = 0.85, 95% CI:0.74–0.97, P for trend = 0.011; HRcopper = 0.80, 95%CI: 0.68–0.94, P for trend = 0.012). Further, equivalently replacing 10% of dietary potassium, calcium and magnesium consumed in the morning with those in the evening were associated with lower mortality risk of cancer (HRpotassium = 0.94, 95%CI:0.91–0.97; HRcalcium = 0.95, 95%CI:0.92–0.98; HRmagnesium = 0.95, 95%CI: 0.92–0.98). Conclusions This study demonstrated that the optimal intake time of potassium, calcium and magnesium for reducing the risk of cancer and all-cause mortality was in the evening.

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“…Another cause suggested that excessive amounts of bile acids in the colonic lumen could be irritating and toxic to the colonic epithelium [30]. The bile acid synthesis has a sharp rise after meals, and the peak occurs at 09:00 to 10:00 p.m. [31]. Hence, higher calcium intake at dinner may be more likely to induce the conversion of bile acids to insoluble calcium compounds, thereby reducing the adverse effect of bile acids on the colonic epithelium and decreasing the incidence of gastrointestinal tumors.…”

Section: Discussionmentioning

confidence: 99%

The association of Minerals Intake in Three Meals with Cancer and All-Cause Mortality: The U.S. National Health and Nutrition Examination Survey, 2003-2014

Huang

et al. 2021

Preprint

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Background: Intake time of diet has recently been demonstrated to be associated with the internal clock and circadian pattern. However, whether and how the intake time of minerals would influence the natural course of cancer was largely unknown. Methods:This study aimed to assess the association of mineral intake at different periods with cancer and all-cause mortality. A total of 27455 participants aged 18-85 years old in the National Health and Nutrition Examination Survey were recruited. The main exposures were the mineral intakes in the morning, afternoon and evening, which were categorized into quintiles, respectively. The main outcomes were mortality of cancer and all causes. Results:During the 178,182 person-years of follow-up, 2680 deaths, including 601 deaths due to cancer, were documented. After adjusting for potential confounders, compared to the participants who were in the lowest quartile(Quartile-1) of mineral intakes at dinner, the participants in the highest quartile intake(Quartile-5) of dietary potassium, calcium and magnesium had lower mortality risks of cancer (HRpotassium=0.72, 95% CI:0.55-0.94; HRcalcium=0.74, 95% CI:0.57-0.98; HRmagnesium=0.75, 95% CI:0.56-0.99) and all-cause (HRpotassium=0.83, 95% CI:0.73-0.94; HRcalcium=0.87, 95% CI:0.76-0.99; HRmagnesium=0.85, 95% CI:0.74-0.97). Further, equivalently replacing 10% of dietary potassium, calcium and magnesium consumed in the morning with those in the evening were associated with lower mortality risk of cancer (HRpotassium=0.94, 95%CI:0.91-0.97; HRcalcium=0.95, 95%CI:0.92-0.98; HRmagnesium=0.95, 95%CI: 0.92-0.98). Conclusions: This study demonstrated that the optimal intake time of potassium, calcium and magnesium for reducing the risk of cancer and all-cause mortality was in the evening.

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Gall bladder: The metabolic orchestrator

Cited by 16 publications

References 76 publications

Association of Cholecystectomy With Liver Fibrosis and Cirrhosis Among Adults in the USA: A Population-Based Propensity Score-Matched Study

Association of Cholecystectomy With Liver Fibrosis and Cirrhosis Among Adults in the USA: A Population-Based Propensity Score-Matched Study

The association of minerals intake in three meals with cancer and all-cause mortality: the U.S. National Health and Nutrition Examination Survey, 2003–2014

The association of Minerals Intake in Three Meals with Cancer and All-Cause Mortality: The U.S. National Health and Nutrition Examination Survey, 2003-2014

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