Gallbladder Interleukins in Children with Calculous Cholecystitis

Deņisova, Arina; Pilmane, Māra; Eņģelis, Arnis; Pētersons, Aigars

doi:10.3390/pediatric13030054

Cited by 5 publications

(2 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IL-6 is a multifunctional glycoprotein consisting of 184 amino acids that can reflect the state of the body's response to inflammation and infection and is highly expressed in the bile and serum of patients with chronic cholecystitis [22,23].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Laparoscopic Cholecystectomy in Patients with Gallbladder Stones with Chronic Cholecystitis

Rao

Zhou

Gao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective. To assess the effectiveness of laparoscopic cholecystectomy in patients with gallbladder stones and chronic cholecystitis. Methods. From July 2018 to January 2020, 90 patients with gallbladder stones and chronic cholecystitis assessed for eligibility were recruited and concurrently assigned (1 : 1) to receive either small-incision cholecystectomy (observation group) or laparoscopic cholecystectomy (experimental group). Outcome measures included operation time, intraoperative bleeding volume, postoperative hospital stay, c-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor-α (TNF-α), gastrin (GAS), vasoactive intestinal peptide (VIP), motilin (MOT), and adverse events. Results. Patients given laparoscopic cholecystectomy showed lower levels of operation-related indices versus those receiving small-incision cholecystectomy ( P < 0.05 ). Laparoscopic cholecystectomy resulted in lower postoperative levels of CRP, IL-6, and TNF-α in the patients versus small-incision cholecystectomy ( P < 0.05 ). Patients receiving laparoscopic cholecystectomy showed better GAS, VIP, and MOT levels than those receiving small-incision cholecystectomy ( P < 0.05 ). The eligible patients after laparoscopic cholecystectomy had a significantly lower incidence of adverse events versus those after small-incision cholecystectomy ( P < 0.05 ). Conclusion. Laparoscopic cholecystectomy effectively shortens the operative time and length of hospital stay in patients with gallbladder stones and chronic cholecystitis, reduces intraoperative bleeding, attenuates the inflammatory response, and enhances the gastrointestinal function, with less surgical trauma and high safety. Clinical trials are, however, required prior to promotion.

show abstract

Section: Discussionmentioning

confidence: 99%

Effectiveness of Laparoscopic Cholecystectomy in Patients with Gallbladder Stones with Chronic Cholecystitis

Rao

Zhou

Gao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Based on the literature, chemerin may be both a pro-inflammatory and anti-inflammatory molecule [ 35 ]. The influence of other markers of inflammation was observed by Denisova et al [ 36 ]. In this study, increased expression of various interleukins (IL-1, IL-4, IL-6, IL-7, IL-8, and IL-17A) was observed in calculous cholecystitis.…”

Section: Reviewmentioning

confidence: 73%

The Etiology of Cholelithiasis in Children and Adolescents—A Literature Review

Zdanowicz

Daniluk

Lebensztejn

et al. 2022

IJMS

View full text Add to dashboard Cite

The incidence of gallstone disease has increased in recent years. The pathogenesis of cholelithiasis is not fully understood. The occurrence of the disease is influenced by both genetic and environmental factors. This article reviews the literature on cholelithiasis in children, with the exception of articles on hematological causes of cholelithiasis and cholelithiasis surgery. The aim of this review is to present the latest research on the pathogenesis of gallstone disease in children. The paper discusses the influence of all factors known so far, such as genetic predisposition, age, infections, medications used, parenteral nutrition, and comorbidities, on the development of gallstone disease. The course of cholelithiasis in the pediatric population is complex, ranging from asymptomatic to life-threatening. Understanding the course of the disease and predisposing factors can result in a faster diagnosis of the disease and administration of appropriate treatment.

show abstract

A Two-step Bayesian Mendelian Randomization Study on Cholecystitis and Dermatitis

Zhao,

Cen,

Zhang

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: Cholecystitis is an inflammatory disease involving the gallbladder, often associated with digestive disorders and systemic immune response. This systemic immune response could potentially influence the immune status of the skin, particularly in conditions like dermatitis. Despite extensive research on dermatitis, the causal relationship between cholecystitis and dermatitis subtypes (DSs) remains unclear. Objective: The aim of this study was to investigate the causal relationship between cholecystitis and DSs. Methods: Two-sample Mendelian randomization (MR) was used to analyze the causal relationship between cholecystitis and DSs. We then utilized the Bayesian Weighted Mendelian Randomization (BWMR) method to validate our findings and applied bidirectional MR analysis to confirm the causal direction. After establishing the associations between traits, we delved into the underlying mechanisms of this interesting finding. Subsequently, we used 91 inflammatory proteins as mediators and performed summary data-based mendelian randomization (SMR) analysis to further investigate the pathogenesis of DSs. Results: MR results evidently showed that cholecystitis can significantly reduce the risk of allergic contact dermatitis (ACD) (IVW, OR=0.8834, p=0.0368) and exfoliative dermatitis (ED) (IVW, OR=0.5738, p=0.0126). BWMR also provided secondary validation of the casual associations. In the subsequent reverse direction MR analyses, reverse causality was not present, so cholecystitis had a unidirectional effect and existed as a protective factor for ACD and ED. Interestingly, cholecystitis appears to lower the risk of ACD and ED by downregulating IL-6, IL-7, and IFN-γ. Additionally, the genes HCG27 and HLA-DRB5 may play a significant role in the pathogenesis of ACD. Conclusion: This study used a two-step MR analysis of genetic summary data to investigate to what extent inflammatory proteins impact the protective role of cholecystitis on dermatitis. We also identified several proteins and genes that could serve as potential drug targets.

show abstract

Gallbladder Interleukins in Children with Calculous Cholecystitis

Cited by 5 publications

References 35 publications

Effectiveness of Laparoscopic Cholecystectomy in Patients with Gallbladder Stones with Chronic Cholecystitis

Effectiveness of Laparoscopic Cholecystectomy in Patients with Gallbladder Stones with Chronic Cholecystitis

The Etiology of Cholelithiasis in Children and Adolescents—A Literature Review

A Two-step Bayesian Mendelian Randomization Study on Cholecystitis and Dermatitis

Contact Info

Product

Resources

About