Gallefluß und Pankreassekretion

Review:The Role of Bile in the Regulation of Exocrine Pancreatic Secretion

“…Under these conditions, 6 g of bile proved to be as potent as a combined stimulus with 1 CHR U/kg secretin and 1 IDU/kg CCK intravenously (17). The amount of bile applied was comparable to that of a full gallbladder (18).…”

“…Intraduodenal application of 2 , 4, and 6 g of dried cattle bile, dissolved in 20 ml of water, induced a dose-dependent increase of basal pancreatic trypsin, lipase, amylase, bicarbonate, and volume secretion (14,17). Under these conditions, 6 g of bile proved to be as potent as a combined stimulus with 1 CHR U/kg secretin and 1 IDU/kg CCK intravenously (17).…”

Exocrine Pancreatic Secretion and Output of Bile in Humans under Conditions of Hypoglycemia and Administration of Atropine

“…In addition we noticed a simultaneous increase in bile discharge into the duodenum. This finding becomes significant in view of experiments of Forell and Stahlheber [4] where for the first time a relation between bile content in the duodenum and excretory pancreatic secretion was described. However, it was surprising to find no effect of atropine on the pancreas and on bile output in insulin hypoglycemia, especially when it is assumed that insulin hypoglycemia is a strong vagal stimulus.…”

“…Possibly other vagolytic drugs with lesser side effects [2] would show an inhibition. The atropine dosage given, however, is sufficient to block the secretory stimulus of bile on the pancreas [4],…”

“…] The following investigation deals with the question whether pancreatic secretion stimulated by hypoglycemia can be suppressed by atropine. The output of bile into the duodenum was tested under these conditions as it is known that bile has a stimulatory effect on the exocrine pancreas [4],…”