Gallic acid for cancer therapy: Molecular mechanisms and boosting efficacy by nanoscopical delivery

Ashrafizadeh, Milad; Zarrabi, Ali; Mirzaei, Sepideh; Hashemi, Farid; Samarghandian, Saeed; Zabolian, Amirhossein; Hushmandi, Kiavash; Ang, Hui Li; Sethi, Gautam; Kumar, Alan Prem; Ahn, Kwang Seok; Nabavi, Noushin; Khan, Haroon; Makvandi, Pooyan; Varma, Rajender S.

doi:10.1016/j.fct.2021.112576

Cited by 84 publications

(32 citation statements)

References 242 publications

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“…In addition to flavonoids, phenolic acids in sea buckthorn are noteworthy. Gallic acid has been reported to have a wide range of biological activities [ 29 , 30 ], and it was recorded with the lowest content of 27.41 mg·100 g −1 in cultivar SG and the highest content of 61.32 mg·100 g −1 in W2; they were higher than the content of gallic acid in four Romanian sea buckthorn (6.51–19.37 mg·kg −1 ) [ 31 ]. The content range of protocatechuic acid was 0.1–3.5 mg·kg −1 in sea buckthorn from Slovakia [ 1 ].…”

Section: Resultsmentioning

confidence: 99%

Impact of Drying Methods on Phenolic Components and Antioxidant Activity of Sea Buckthorn (Hippophae rhamnoides L.) Berries from Different Varieties in China

Yang

et al. 2021

Molecules

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Sea buckthorn berries are rich in bioactive compounds and can be used for medicine and food. The variety and drying method used have an important influence on quality. In this study, different sea buckthorn varieties from China were selected and dried with four common drying methods. The total phenolic content (TPC), total flavonoids content (TFC), contents of 12 phenolic compounds and antioxidant capacity in vitro were analyzed. The results showed that the TPC, TFC and antioxidant activity of two wild sea buckthorn berries were higher than those of three cultivated berries, and for the same varieties, measured chemical contents and antioxidant activity of the freeze-dried fruit were significantly higher than those obtained with three conventional drying methods. In addition, forty-one compounds in sea buckthorn berry were identified by UPLC-PDA-Q/TOF-MS, most of which were isorhamnetin derivatives. Multivariate statistical analysis revealed narcissin and isorhamnetin-3-O-glucoside varied significantly in sea buckthorn berries of different varieties and with different drying methods; they were potential quality markers. Strong correlations were found between TPC, gallic acid and antioxidant capacity (p < 0.05). The results revealed how components and antioxidant activity varied in different sea buckthorn, which provides a valuable reference for quality control and further development and utilization of sea buckthorn.

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Section: Resultsmentioning

confidence: 99%

Impact of Drying Methods on Phenolic Components and Antioxidant Activity of Sea Buckthorn (Hippophae rhamnoides L.) Berries from Different Varieties in China

Yang

et al. 2021

Molecules

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“…However, the metal ions attached to albumin are prone to uncontrolled release without specificity, leading to unsatisfactory copper dosages for CDT and latent toxicity issues [ 33 , 34 ]. Gallic acid (GA) is a polyphenol derived from tea that has been widely used in the pharmaceutical industry due to its economical and accessible extraction procedure [ 35 ]. Several nanoscale coordination polymers (NCPs) have been synthesized through the chelation reaction between metal ions and the carboxyl and phenolic hydroxyl groups of GA [ 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Tumor microenvironment-responsive BSA nanocarriers for combined chemo/chemodynamic cancer therapy

Zhang

Teng

et al. 2022

J Nanobiotechnol

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Tumor microenvironment (TME), characterized by high glutathione (GSH), high hydrogen peroxide (H2O2) and acidic pH levels, is favorable for the growth, invasion and metastasis of cancer cells. Taking advantage of the specific characteristics of tumors, TME-responsive GCBD NPs are designed to deliver nanoscale coordination polymers (NCPs, GA-Cu) and chemotherapy drugs (doxorubicin, DOX) based on bovine serum albumin (BSA) nanocarriers into cancer cells for combined chemodynamic therapy (CDT) and chemotherapy. In an acidic environment, GCBD NPs could release approximately 90% copper ions, which can not only consume overexpressed GSH to modulate the TME but can also react with endogenous H2O2 in a Fenton-like reaction to achieve the CDT effect. Meanwhile, the released DOX could enter the nucleus of tumor cells and affect their proliferation to achieve efficient chemotherapy. Both in vitro and in vivo experiments showed that GCBD NPs had good biosafety and could effectively inhibit the growth of cancer cells. GCBD NPs are promising as a biocompatible nanoplatform to exploit TME characteristics for combined chemo and chemodynamic therapy, providing a novel strategy to eradicate tumors with high efficiency and specificity. Graphical Abstract

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“…Therefore, the differences in the anti-proliferative activity of the three compounds are probably dependent on factors other than the control of rRNA transcription. It has been reported that gallic acid down-regulates pathways involved in cancer progression, such as PI3K/Akt [ 24 ]. Therefore, we speculate that this signaling pathway may also affect the anti-proliferative activity of gallic acid derivatives.…”

Section: Discussionmentioning

confidence: 99%

Gallic Acid Derivatives Propyl Gallate and Epigallocatechin Gallate Reduce rRNA Transcription via Induction of KDM2A Activation

Tanaka

Tsuneoka

2021

Biomolecules

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We previously reported that lysine-demethylase 2A (KDM2A), a Jumonji-C histone demethylase, is activated by gallic acid to reduce H3K36me2 levels in the rRNA gene promoter and consequently inhibit rRNA transcription and cell proliferation in the breast cancer cell line MCF-7. Gallic acid activates AMP-activated protein kinase (AMPK) and increases reactive oxygen species (ROS) production to activate KDM2A. Esters of gallic acid, propyl gallate (PG) and epigallocatechin gallate (EGCG), and other chemicals, reduce cancer cell proliferation. However, whether these compounds activate KDM2A has yet to be tested. In this study, we found that PG and EGCG decreased rRNA transcription and cell proliferation through KDM2A in MCF-7 cells. The activation of both AMPK and ROS production by PG or EGCG was required to activate KDM2A. Of note, while the elevation of ROS production by PG or EGCG was limited in time, it was sufficient to activate KDM2A. Importantly, the inhibition of rRNA transcription and cell proliferation by gallic acid, PG, or EGCG was specifically observed in MCF-7 cells, whereas it was not observed in non-tumorigenic MCF10A cells. Altogether, these results suggest that the derivatization of gallic acid may be used to obtain new compounds with anti-cancer activity.

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Gallic acid for cancer therapy: Molecular mechanisms and boosting efficacy by nanoscopical delivery

Cited by 84 publications

References 242 publications

Impact of Drying Methods on Phenolic Components and Antioxidant Activity of Sea Buckthorn (Hippophae rhamnoides L.) Berries from Different Varieties in China

Impact of Drying Methods on Phenolic Components and Antioxidant Activity of Sea Buckthorn (Hippophae rhamnoides L.) Berries from Different Varieties in China

Tumor microenvironment-responsive BSA nanocarriers for combined chemo/chemodynamic cancer therapy

Gallic Acid Derivatives Propyl Gallate and Epigallocatechin Gallate Reduce rRNA Transcription via Induction of KDM2A Activation

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