Gallic acid-loaded montmorillonite nanostructure as a new controlled release system

Rabiei, Morteza; Sabahi, Hossein; Rezayan, Ali Hossein

doi:10.1016/j.clay.2015.10.020

Cited by 33 publications

(9 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Here, the adsorption may involve interaction mechanisms such as cationic bridges between anionic GA and divalent inorganic cations. Hence, even mostly compensated with Na + , around 20% of the compensating inorganic cations of Na-Mt are Ca 2+ , that are able to sorb anionic species through cationic bridges (Errais et al, 2012;Thiebault et al, 2016;Rabiei et al, 2016). It should be mentioned that this mechanism could also play a key-role at pH = 5, although the distinction between these mechanisms is not possible based on these experiments (Fig.…”

Section: Adsorption Mechanisms and Geochemical Model Of Ga-mt Complexesmentioning

confidence: 89%

Phenolic acids interactions with clay minerals: A spotlight on the adsorption mechanisms of Gallic Acid onto montmorillonite

Ahmat

Thiebault

Guégan

2019

Applied Clay Science

View full text Add to dashboard Cite

For a better understanding of the preservation of organic matter in clay minerals, the 1 adsorption of a model humic substance, the Gallic Acid (GA), onto a Na-montmorillonite 2 (Na-Mt) was performed in batch situation for various experimental conditions (pH=2, 5, 7) in 3 order to mimic the natural context. The adsorption efficiency and change in the clay mineral 4 were characterized via a set of complementary experimental techniques (Fourier transform 5 infrared spectroscopy, X-ray diffraction, elemental analyses). Adsorption isotherms at the 6 equilibrium were fitted with the models of Langmuir, Freundlich and Dubinin-Radushkevitch 7 allowing one to precisely quantify the adsorption through the derived fitting parameters. From 8 the adsorption data combined with complementary results of the modeled humic-clay 9 complexes, different types of interactional mechanisms were inferred as a function of 10 background acidity: (i) at pH=2 while protonated GA was the preponderant form, anionic GA 11 species can be adsorbed to the Na-Mt surface through electrostatic interaction, leading to the a 12

show abstract

Section: Adsorption Mechanisms and Geochemical Model Of Ga-mt Complexesmentioning

confidence: 89%

Phenolic acids interactions with clay minerals: A spotlight on the adsorption mechanisms of Gallic Acid onto montmorillonite

Ahmat

Thiebault

Guégan

2019

Applied Clay Science

View full text Add to dashboard Cite

show abstract

“…1 shows FTIR spectra of montmorillonite (MMT 0 ), citric acid activated montmorillonite (MMT 1 ) and drug delivery system metformin HCl/montmorillonite (MMT 2 ). In the FTIR spectrum of montmorillonite (MMT 0 ), absorption bands at 3626.17 and 3695.61 cm -1 indicate the stretching vibration of the -OH group (Al-OH and Si-OH of octahedral and tetrahedral layers) on the montmorillonite framework [12]. The absorption band at 1631.78 cm -1 indicates the H-O-H bending mode of adsorbed water [17,18].…”

Section: Resultsmentioning

confidence: 99%

“…Since the knowledge of their physical and chemical properties, the applications of montmorillonites were primarily focused on drug delivery systems [9]. The use of montmorillonite as a carrier of drugs has been reported by some researchers such as chlorhexidine acetate [10], platinum anticancer complex in vitro Controlled Drug Release of Antidiabetic Metformin HCl from Citric Acid Activated Natural Montmorillonite [11], gallic acid [12] and gentamycin [13]. Among the numerous studies, the use of montmorillonite as carrier of metformin HCl has not been reported.…”

Section: Introductionmentioning

confidence: 99%

in vitro Controlled Drug Release of Antidiabetic Metformin HCl from Citric Acid Activated Natural Montmorillonite

Putra¹,

Sitanggang²,

Suarya³

et al. 2017

Asian J. Chem.

View full text Add to dashboard Cite

In this work, metformin HCl was encapsulated on citric acid activated montmorillonite as drug delivery system. The as-synthetized drug delivery systems were characterized by using FTIR and X-ray diffraction. FTIR spectra showed the presence of bending vibration of N-H from primary amines group and streching vibration of C=N at 1635.64 and 1506.41 cm -1 , respectively. X-ray diffraction pattern also showed a widening of the diffraction peaks of montmorillonite after encapsulated by metformin HCl. In vitro drug release results showed that the release of metformin HCl from the drug delivery system in simulated intestinal fluid (pH 7.4) higher than that in simulatied gastric fluid (pH 1.2) with a value of drug release of 61.44 % and 39.41 %. Metformin HCl release kinetics at each pH follow the zero-order model (pH 1.2 with R = 0.9924; pH 7.4 with R = 0.9972) suggested diffusion-controlled release mechanism.

show abstract

“…In the lower pH (1.2), the release of metformin HCl was observed reaching 83.36% within 7 h. Furthermore, the release of metformin HCl took place slowly until it reaches 85.32% in 12 h. In the higher pH (7.4), the drug release occurred very fast until the first 2 h. This is due to the weak interaction between drug molecules and the surface of clinoptilolites. In addition, the hydrophilic properties of metformin HCl also have an effect on this stage [49]. Subsequently, drug release occurred quite slowly (71.10% of drug release in 12 h).…”

Section: Drug Release Studymentioning

confidence: 99%

The Use of Clinoptilolites as Carrier of Metformin Hydrochloride in Drug Delivery System: In Vitro Drug Release Study

Putra

Kusumawati

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: As an antidiabetic drug, metformin hydrochloride (HCl) has been well known to possess low oral bioavailability and short half-life. In this study, we prepared the drug delivery system (DDS) of metformin HCl and clinoptilolite as its carrier. The in vitro drug release profile was further investigated.Methods: DDS was made by encapsulating metformin HCl on clinoptilolite using the wet impregnation method at various pH and initial concentration of metformin HCl. Fourier transform infrared spectrometer (FTIR), X-ray diffractometer (XRD), and N2 Sorption Analyzer were used to characterize the as-synthesized DDS. Drug release study was conducted by stirring the DDS in simulated gastric fluid and simulated intestinal fluid over 12 h.Results: The encapsulation process was achieved optimally at pH 7.0 and initial concentration of metformin HCl of 300 mg/l (CLI2-300 denoted DDS). The results of FTIR and N2 sorption analyzer confirmed the existence of metformin HCl on clinoptilolites. Meanwhile, the XRD result showed that the crystallinity of clinoptilolites remained unchanged after the encapsulation process. The cumulative drug release in the simulated gastric fluid was found to be higher than that in the simulated intestinal fluid, which indicated the potent influence of pH on the release properties of the drugs. The drug release kinetics of metformin HCl from clinoptilolite was best fitted into the Korsmeyer-Peppas model with non-Fickian transport mechanism.Conclusion: We found that clinoptilolite was suitable for DDS application, particularly as a carrier of metformin HCl.

show abstract

Gallic acid-loaded montmorillonite nanostructure as a new controlled release system

Cited by 33 publications

References 62 publications

Phenolic acids interactions with clay minerals: A spotlight on the adsorption mechanisms of Gallic Acid onto montmorillonite

Phenolic acids interactions with clay minerals: A spotlight on the adsorption mechanisms of Gallic Acid onto montmorillonite

in vitro Controlled Drug Release of Antidiabetic Metformin HCl from Citric Acid Activated Natural Montmorillonite

The Use of Clinoptilolites as Carrier of Metformin Hydrochloride in Drug Delivery System: In Vitro Drug Release Study

Contact Info

Product

Resources

About