Gallic acid prevents ketamine-induced oxidative damages in brain regions and liver of rats

Schimites, Paula Ivanir; Segat, Hecson Jesser; Teixeira, Luciele Varaschini; Martins, Letícia Reginato; Mangini, Lynn; Baccin, Pery; Rosa, Higor Zuquetto; Milanesi, Laura Hautrive; Bürger, Marilise Escobar; Soares, André Luís Ramos

doi:10.1016/j.neulet.2019.134560

Cited by 25 publications

(16 citation statements)

References 35 publications

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“…GA is a planar molecule consisting of an aromatic ring with three phenolic hydroxyl groups that scavenge ROS and RNS and avoid reducing first-line antioxidant enzymes’ activity to prevent oxidative stress ( Badhani et al, 2015 ). GA scavenges reactive species and free radicals, avoiding neuronal death against different insults ( Mirshekari Jahangiri et al, 2020 ; Schimites et al, 2020 ). Another beneficial effect of GA on neuronal excitotoxicity is reducing the glutamate release and intracellular calcium currents that avoid subcellular stress in the mitochondria and the endoplasmic reticulum ( Ban et al, 2008 ).…”

Section: Discussionmentioning

confidence: 99%

Gallic Acid Prevents the Oxidative and Endoplasmic Reticulum Stresses in the Hippocampus of Adult-Onset Hypothyroid Rats

et al. 2021

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Thyroid hormone is essential for hippocampal redox environment and neuronal viability in adulthood, where its deficiency causes hypothyroidism related to oxidative and endoplasmic reticulum stresses in the hippocampus, resulting in neuronal death. One option of treatment is antioxidants; however, they must be transported across the blood-brain barrier. Gallic acid is a polyphenol that meets these criteria. Thus, this study aimed to prove that the neuroprotective mechanism of GA is associated with the prevention of oxidative and endoplasmic reticulum stresses in the hippocampus of adult-onset hypothyroid rats. Male Wistar rats were divided into euthyroid (n = 20) and hypothyroid groups (n = 20). Thyroidectomy with parathyroid gland reimplementation caused hypothyroidism. Each group was subdivided into two: vehicle and 50 mg/kg/d of gallic acid. 3 weeks after thyroidectomy, six animals of each group were euthanized, and the hippocampus was dissected to evaluate oxidative and endoplasmic reticulum stress markers. The rest of the animals were euthanized after 4 weeks of treatment for histological analysis of the hippocampus. The results showed that hypothyroidism increased lipid peroxidation, reactive oxygen species, and nitrites; it also increased endoplasmic reticulum stress by activating the inositol-requiring enzyme-1α (IRE1α) pathway, the protein kinase RNA-like endoplasmic reticulum kinase (PERK) and activated transcription factor 6α (ATF6α) pathways associated with a proapoptotic state that culminates in hippocampal neuronal damage. Meanwhile, the hypothyroid rat treated with gallic acid reduced oxidative stress and increased endoplasmic reticulum-associated degradation (ERAD) through IRE1α and ATF6. Also, the gallic acid treatment prevented the Bax/BCl2 ratio from increasing and the overexpression of p53 and caspase 12. This treatment in hypothyroid animals was associated with the neuronal protection observed in the hippocampus. In conclusion, gallic acid prevents hypothyroidism-induced hippocampal damage associated with oxidative and endoplasmic reticulum stresses.

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Section: Discussionmentioning

confidence: 99%

Gallic Acid Prevents the Oxidative and Endoplasmic Reticulum Stresses in the Hippocampus of Adult-Onset Hypothyroid Rats

et al. 2021

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“…Among many polyphenols, GA is a low molecular weight tri-phenolic compound with excellent anti-inflammatory and anti-oxidative activities [164]. In addition, GA also has several evident pharmacological effects including anti-tumor, anti-bacterial, antidiabetes, anti-obesity, anti-microbial and anti-cardio cerebral ischemia [165][166][167][168].…”

Section: Gallic Acidmentioning

confidence: 99%

Traditional medicine in China for ischemic stroke: bioactive components, pharmacology, and mechanisms

Xu¹,

Wu²,

Li³

et al. 2022

J. Integr. Neurosci.

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Ischemic stroke is an acute cerebrovascular disease and the third most common cause of death a ter ischemic heart disease. Increasing attention is being paid to finding e fective treatments through traditional medicine. Thus, studying the traditional medicine for the treatment of ischemic stroke is of great importance. Traditional medicine in China includes traditional Chinese medicine (TCM) and other ethnic medicines, which is rich in variety and resources. This review first introduces the treatment mechanisms associated with ischemic stroke, such as antioxidant nitrification, antiexcitotoxic, antiapoptotic, anti-in lammatory, antiplatelet and anticoagulation mechanisms. Then, we calculated the frequency of prescription use for ischemic stroke and summarized the treatments for ischemic stroke by investigating 13 drug monographs and standards. We found 192 prescriptions from the traditional medical system for ischemic stroke, including Angong Niuhuang pill, Qishiwei Zhenzhu Pills, Ginkgo biloba leaf, and other traditional Chinese patent medicines and national medicines. There were 398 kinds of traditional medicine, including 301 kinds of plant-based medicines, 54 kinds of animal-based medicines, 28 kinds of mineralbased medicines, and 15 kinds of other medicines. We introduced the names, families, medicinal components, traditional uses, phytochemical information, and pharmacological activities of the commonly used Chinese patent medicines and TCMs. In addition, some chemicals were introduced. These medicines may be potential candidates for the treatment of ischemic stroke. This work provides a reference for the research and clinical use of new drugs for ischemic stroke.

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“…Only Tiébissou and Yamoussoukro peels contained gallic acid, which was also the majority compound. Gallic acid is able to reverse oxidative damages induced by lead (Pb) and prevents ketamine-induced oxidative damages [61][62][63]. This could justify their high antioxidant power compared to pulp.…”

Section: Antioxidant Activities Of Black Plum (V Doniana) Fruit Pulp and Peel Dpph Radical Scavenging Activitymentioning

confidence: 99%

Phenolic compounds characterisation and antioxidant activity of black plum (Vitex doniana) fruit pulp and peel from Côte d’Ivoire

et al. 2020

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This study was conducted to first determine the phenolic compounds and then the antioxidant activity of black plum fruit pulp and peel. For these characterisations, classic methods were used. Moreover, the ability of extracts to scavenge free radicals and their reducing power were measured according to 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) methods, respectively. The total polyphenol, flavonoid and anthocyanin contents of pulp and peel ranged from 202.51 ± 4.19 to 463.45 ± 6.85 mg gallic acid equivalent (GAE)/100 g of Dry Weight (DW), 75.71 ± 1.03 to 145.55 ± 1.03 mg quercetin equivalent (QE)/100 g DW, and from 1.91 ± 0.08 to 8.28 ± 0.83 mg cyanidin 3-O-β-D-glucoside equivalent (C3GE)/100 g DW respectively. However, these compounds were higher in peel extracts than in pulp extracts. In addition, peel extract showed the strongest antioxidant capacities. Significant correlations were found between methods applied to determine antioxidant activity (DPPH and FRAP) in black plum pulp and peel extracts and their total phenols and flavonoids contents. Cinnamic acid and gallic acid were mains phenols in pulp and peel extracts respectively, except fruits peel from Ferke where the main phenol was cinnamic acid. Thus, peel of black plum fruit could be used as an inexpensive and natural source of antioxidants and contribute to the prevention of degenerative diseases.

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Gallic acid prevents ketamine-induced oxidative damages in brain regions and liver of rats

Cited by 25 publications

References 35 publications

Gallic Acid Prevents the Oxidative and Endoplasmic Reticulum Stresses in the Hippocampus of Adult-Onset Hypothyroid Rats

Gallic Acid Prevents the Oxidative and Endoplasmic Reticulum Stresses in the Hippocampus of Adult-Onset Hypothyroid Rats

Traditional medicine in China for ischemic stroke: bioactive components, pharmacology, and mechanisms

Phenolic compounds characterisation and antioxidant activity of black plum (Vitex doniana) fruit pulp and peel from Côte d’Ivoire

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