Gallic acid regulates immune response in a mouse model of rheumatoid arthritis

Liu, Siqin; Li, Jiajia; Feng, Le‐heng

doi:10.1002/iid3.782

Cited by 6 publications

(2 citation statements)

References 29 publications

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“…Moreover, cinnamic acid modulates inflammatory cytokines in adipose tissue, the liver, the hypothalamus, and decreases TNF-α in serum [34]. Gallic acid is known for its strong free radical scavenging activities and antiinflammatory properties; it has also shown immunomodulatory effects, as supported by a decrease in the inflammation cytokines and an increase of anti-inflammatory cytokines [35]. Additionally reported data stated that rutin has an immune regulatory effect, which can regulate cytokines and immune-related signaling pathways and cause a strong enhancement of antibody levels, increase immunoglobulin levels, and restore the functioning of leucocytes [36].…”

Section: Discussionmentioning

confidence: 99%

Galangal–Cinnamon Spice Mixture Blocks the Coronavirus Infection Pathway through Inhibition of SARS-CoV-2 MPro, Three HCoV-229E Targets; Quantum-Chemical Calculations Support In Vitro Evaluation

El-Hosari,

Hussein,

Elgendy

et al. 2023

Pharmaceuticals

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Natural products such as domestic herbal drugs which are easily accessible and cost-effective can be used as a complementary treatment in mild and moderate COVID-19 cases. This study aimed to detect and describe the efficiency of phenolics detected in the galangal–cinnamon mixture in the inhibition of SARS-CoV-2’s different protein targets. The potential antiviral effect of galangal–cinnamon aqueous extract (GCAE) against Low Pathogenic HCoV-229E was assessed using cytopathic effect inhibition assay and the crystal violet method. Low Pathogenic HCoV-229E was used as it is safer for in vitro laboratory experimentation and due to the conformation and the binding pockets similarity between HCoV-229E and SARS-CoV-2 MPro. The GCAE showed a significant antiviral effect against HCoV-229E (IC50 15.083 µg/mL). Twelve phenolic compounds were detected in the extract with ellagic, cinnamic, and gallic acids being the major identified phenolic acids, while rutin was the major identified flavonoid glycoside. Quantum-chemical calculations were made to find molecular properties using the DFT/B3LYP method with 6-311++G(2d,2p) basis set. Quantum-chemical values such as EHOMO, ELUMO, energy gap, ionization potential, chemical hardness, softness, and electronegativity values were calculated and discussed. Phenolic compounds detected by HPLC-DAD-UV in the GCAE were docked into the active site of 3 HCoV-229E targets (PDB IDs. 2ZU2, 6U7G, 7VN9, and 6WTT) to find the potential inhibitors that block the Coronavirus infection pathways from quantum and docking data for these compounds. There are good adaptations between the theoretical and experimental results showing that rutin has the highest activity against Low Pathogenic HCoV-229E in the GCAE extract.

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Section: Discussionmentioning

confidence: 99%

Galangal–Cinnamon Spice Mixture Blocks the Coronavirus Infection Pathway through Inhibition of SARS-CoV-2 MPro, Three HCoV-229E Targets; Quantum-Chemical Calculations Support In Vitro Evaluation

El-Hosari,

Hussein,

Elgendy

et al. 2023

Pharmaceuticals

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“…Besides, a shift in the Th17/Treg cell balance towards the Treg cell side has been shown to lead to increased levels of IL‐10 and TGF‐β, while decreasing IL‐17 levels 11 . The treatment of gallic acid modulates the Th17/Treg cell balance, resulting in increased expression of IL‐10 and TGF‐β, and reduced levels of IL‐17 33 . Consistent with previous studies, our findings demonstrated significant positive correlations between serum TGF‐β1 and IL‐17 and IL‐21 levels in CSU patients, while serum IL‐35 levels exhibited significant negative correlations with IL‐17 and IL‐21 levels.…”

Section: Discussionmentioning

confidence: 99%

The correlation between Th17/Treg immune dysregulation and the disease severity in chronic spontaneous urticaria patients

Yang

Wang

et al. 2023

Immunity Inflam & Disease

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Objective Chronic spontaneous urticaria (CSU) has a profound impact on the sleep quality, productivity and overall quality of life of affected individuals. This study aimed to investigate the correlation between serum Th17/Treg immune dysregulation and the severity of CSU in patients. Methods Clinical baseline data of 120 CSU patients and matched healthy controls were recorded. The pruritus level, disease severity, and quality of life of CSU patients were assessed using the visual analogue scale, weekly Urticaria Activity Score and chronic urticaria quality of life questionnaire, respectively. The Th17/Treg cell ratio was detected by flow cytometry. ELISA was used to measure the levels of serum Th17 cytokines (IL‐17, IL‐21) and Treg cytokines (TGF‐β1, IL‐35). Pearson's correlation analysis was conducted to examine the associations between these indicators. Results No significant differences were identified in terms of sex, age, and BMI between the two groups. However, CSU patients exhibited a significant increase in the Th17 cell ratio, as well as the elevated serum levels of TGF‐β1, IL‐17 and, IL‐21. Conversely, the proportion of Treg cells and the levels of IL‐35 were remarkably decreased in CSU patients. Peripheral blood Th17 cells were negatively correlated with Treg cells. The severity of pruritus, life quality, and disease severity in CSU patients were positively correlated to Th17 cell ratio, and inversely correlated with Treg cell proportion. Conclusions A positive correlation was found between the percentage of peripheral blood Th17 cell in CSU patients and the pruritus level, life quality, and disease severity. In constrast, there was a negative correlation between the proportion of peripheral blood Treg cells and these clinical parameters.

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Anti-arthritic and immunomodulatory efficacy of Micromeria biflora Benth extract and its fractions in rats by restoring oxidative stress, metalloproteinases, pro-inflammatory and anti-inflammatory cytokines network

Al-Joufi,

Uttra,

Qasim

et al. 2024

Inflammopharmacol

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Gallic acid regulates immune response in a mouse model of rheumatoid arthritis

Cited by 6 publications

References 29 publications

Galangal–Cinnamon Spice Mixture Blocks the Coronavirus Infection Pathway through Inhibition of SARS-CoV-2 MPro, Three HCoV-229E Targets; Quantum-Chemical Calculations Support In Vitro Evaluation

Galangal–Cinnamon Spice Mixture Blocks the Coronavirus Infection Pathway through Inhibition of SARS-CoV-2 MPro, Three HCoV-229E Targets; Quantum-Chemical Calculations Support In Vitro Evaluation

The correlation between Th17/Treg immune dysregulation and the disease severity in chronic spontaneous urticaria patients

Anti-arthritic and immunomodulatory efficacy of Micromeria biflora Benth extract and its fractions in rats by restoring oxidative stress, metalloproteinases, pro-inflammatory and anti-inflammatory cytokines network

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