Gallium compounds in nuclear medicine and oncology

Mikuš, Peter; Melnik, M.I.; Forgacsova, Andrea; Krajčiová, Dominika; Havránek, E

doi:10.1515/mgmc-2014-0009

Cited by 14 publications

(7 citation statements)

References 58 publications

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“…For example, lung cancers seem to be resistant to gallium compounds because of over-expression of tyrosineprotein kinase receptors (Oyewumi et al, 2014). Starting from the promising results of gallium compounds undergoing clinical trials, the development of new gallium compounds, as well as the study of their mechanism of activity, seems to be one of the key topics of anticancer research in the next years (Mikuš et al, 2014).…”

Section: Galliummentioning

confidence: 99%

Coordination compounds in cancer: Past, present and perspectives

Trudu¹,

Amato

Vaňhara³

et al. 2015

J Appl Biomed

136

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Section: Galliummentioning

confidence: 99%

Coordination compounds in cancer: Past, present and perspectives

Trudu¹,

Amato

Vaňhara³

et al. 2015

J Appl Biomed

136

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“…7 Moreover, the radioactive isotopes 67 Ga and 68 Ga are used in nuclear medicine for SPECT and PET imaging, respectively. [8][9][10][11][12] In recent years, 68 Gabased radiopharmaceuticals have been considered increasingly attractive due to their growing clinical applications. This development has been facilitated by the advancement in the application of some corresponding 177 Lu-and 90 Y-tagged radiotherapeutics, as their theranostic companions in the treatment of different tumors.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and in vitro cytotoxicity of gallium(iii)-dithiocarbamate complexes

Salvarese,

Morellato,

Gobbi

et al. 2024

Dalton Trans.

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“…Ga has several radionuclides that have been used in medicine to treat and diagnose illnesses. In addition to protein and DNA synthesis, and DNA inhibition, the activity of enzymes such as serum alkaline phosphatase is inhibited [ 5 , 6 ]. Extensive exposure to Ga concentrations is expected to improve the therapeutic index of cancer diseases.…”

Section: Introductionmentioning

confidence: 99%

Regulation of Sirtuin-3 and ERK1/2/p38MAPK by the combination Ga nanoparticles/γ-radiation low dosage: an effective approach for treatment of hepatocellular carcinoma

Abdalla

El-Mahdy

Mansour

et al. 2022

Journal of Genetic Engineering and Biotechnology

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Background Synthesized gallium nanoparticles synthesized by grape seed extract were characterized with spherical shape and size range less than100 nm, possessing the functional groups of the biological material. The purpose of this study is to evaluate gallium nanoparticles synthesized by grape seed extract, as an antitumor agent with low dose of γ-radiation against hepatocellular carcinoma in rats. Aim of work This work aimed to evaluate the antitumor effect of gallium nanoparticles synthesized (GaNPs) by grape seed extract and the co-binded treatment with low dose of γ-radiation on hepatocellular carcinoma in rats, through evaluating their effect on signaling pathways and tumor markers. Results Cytotoxic activity of GaNPs synthesized by grape seed extract was estimated by mediated cytotoxicity assay on HepG2 cell line that recorded IC50 of 388.8 μg/ml. To achieve these goals, eighty Wistar male rats (120−150 g) will be divided into eight groups, each of 10 rats. The animals are administered with diethylnitrosamine to induce hepatocellular carcinoma and then orally administered with GaNPs synthesized by grape seed extract (38.5 mg/kg) in combination with the exposure of the total body to a low dose of γ-radiation (0.5 Gy). The treatment modulated plasma vascular endothelial growth factor and alpha-fetoprotein. In addition, the immunoblotting results of nuclear factor-kappa beta showed a marked downregulation of extracellular signal-regulated kinase, mitogen-activated protein kinase, and c-Jun NH2-terminal kinase alongside, significantly elevating the level of Sirtuin-3 and caspase-3. Conclusions It can be concluded that the combined treatment with GaNPs synthesized by grape seed extract and low dose γ-radiation may have antineoplastic activity against hepatocarcinogenesis by inhibiting signal pathways extracellular signal-regulated kinase/mitogen-activated protein kinase/c-Jun NH2-terminal kinase and stimulating apoptotic protein.

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Gallium compounds in nuclear medicine and oncology

Abstract: An overview of the most important gallium compounds in nuclear medicine and oncology in the two last decades, with an emphasis on the last decade (especially the last 5 years), is given in this review. You can also find here some recent knowledge about 68

Cited by 14 publications

References 58 publications

Coordination compounds in cancer: Past, present and perspectives

Coordination compounds in cancer: Past, present and perspectives

Synthesis, characterization and in vitro cytotoxicity of gallium(iii)-dithiocarbamate complexes

Regulation of Sirtuin-3 and ERK1/2/p38MAPK by the combination Ga nanoparticles/γ-radiation low dosage: an effective approach for treatment of hepatocellular carcinoma

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