Several types of T-cell non-Hodgkin's lymphomas are characterized by liver involvement, usually in the context of generalized lymphoma disease. The aggressive neoplasm, T-cell prolymphocytic leukemia, showing a proliferation of small-to medium-sized T cells, results in massive bone marrow infiltration and marrow failure but also infiltrates the lymph nodes, liver, and spleen. Hepatic infiltrates mostly involve portal tracts, causing hepatomegaly. Hepatic involvement is a common feature of T-cell large granular lymphocytic leukemia. Liver infiltration is also known for aggressive NK cell leukemia, a systemic proliferation of NK cells almost always associated with EBV infection. The liver may be densely infiltrated by large granular lymphocytes with azurophilic granules. The generalized neoplastic T-lymphocyte process, adult T-cell leukemia/lymphoma, is frequently complicated by focal t diffuse parenchymal or portal tract infiltration of the liver. Other T-cell neoplasms variably involving the liver comprise nasal-type extranodal NK/T-cell lymphoma, hepatosplenic T-cell lymphoma, mycosis fungoides, Sézary syndrome, and peripheral T-cell lymphomas. T-Cell Prolymphocytic Leukemia ICD-O Code 9834/3 T-Cell Large Granular Lymphocytic Leukemia ICD-O Code 9831/3 T-cell receptor genes are in germline configuration and, therefore cannot be employed for clonality assessment. A part of the cases reveal clonal del (6)(q21q25) and 11q deletion.