Gallstones in Pregnancy

Celaj, Stela; Kourkoumpetis, Themistoklis

doi:10.1001/jama.2021.4502

Cited by 13 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Unlike previous reports, a higher prevalence of gallstones among men was observed in this study. Several classic epidemiologic studies have reported that pregnancy and female sex hormones place women at a higher risk [3–6]. The high prevalence of gallstones among men in our study population is an indicator of a significant shift in the epidemiology of gallstone disease.…”

Section: Discussionmentioning

confidence: 65%

“…Established risk factors for the development of cholesterol gallstones due to enhanced cholesterol synthesis and secretion include genetic background and lifestyle, as well as internal disorders such as aging, female sex, pregnancy, obesity, rapid weight loss, diabetes mellitus, and dyslipidemia [5][6][7][8][9][10]. Predominant risk factors for pigment stones include liver dysfunction [11], Crohn's disease [12], and hyperbilirubinemia due to underlying genetic predisposition [13].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Risk factors for gallstone disease onset in Japan: findings from the Shizuoka Study, a population-based cohort study

Higashizono

Nakatani

Hawke

et al. 2022

Preprint

View full text Add to dashboard Cite

In the research literature on factors associated with gallstones, large population-based cohort studies are rare. We carried out a study of this type to explore risk factors for the onset of gallstones. This study included Japanese participants aged 40-107 years who were followed prospectively from January 2012 to September 2020 using a dataset composed of two individually linked databases, one containing annual health checkup records and the other containing medical claims for beneficiaries of the National Health Insurance System and the Medical Care System for Elderly in the Latter Stage of Life in Shizuoka Prefecture, Japan. Among the 611,930 participants in the analysis set, 23,843 (3.9%) were diagnosed with gallstones during the observational period (median [max]: 5.68 [7.5] years). Multivariate analysis revealed that risk of gallstone disease was increased by male sex, cerebrovascular disease, any malignancy, dementia, rheumatic disease, chronic pulmonary disease, hypertension, and H. pylori-infected gastritis. These findings provide essential insights into the etiology of cholelithiasis and may contribute to efforts to reduce the incidence of the disease.

show abstract

Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Risk factors for gallstone disease onset in Japan: findings from the Shizuoka Study, a population-based cohort study

Higashizono

Nakatani

Hawke

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Hormonal changes during pregnancy may predispose patients to gallstone formation [ 9 ]. The literature estimates a 0.01–0.06% incidence of cholecystitis during pregnancy, though modern data are lacking [ 10 ].…”

Section: Description Of the Health Problemsmentioning

confidence: 99%

SAGES guidelines for the use of laparoscopy during pregnancy

Kumar,

Collings,

Wunker

et al. 2024

Surg Endosc

View full text Add to dashboard Cite

Background When pregnant patients present with nonobstetric pathology, the physicians caring for them may be uncertain about the optimal management strategy. The aim of this guideline is to develop evidence-based recommendations for pregnant patients presenting with common surgical pathologies including appendicitis, biliary disease, and inflammatory bowel disease (IBD). Methods The Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) Guidelines Committee convened a working group to address these issues. The group generated five key questions and completed a systematic review and meta-analysis of the literature. An expert panel then met to form evidence-based recommendations according to the Grading of Recommendations Assessment, Development, and Evaluation approach. Expert opinion was utilized when the available evidence was deemed insufficient. Results The expert panel agreed on ten recommendations addressing the management of appendicitis, biliary disease, and IBD during pregnancy. Conclusions Conditional recommendations were made in favor of appendectomy over nonoperative treatment of appendicitis, laparoscopic appendectomy over open appendectomy, and laparoscopic cholecystectomy over nonoperative treatment of biliary disease and acute cholecystitis specifically. Based on expert opinion, the panel also suggested either operative or nonoperative treatment of biliary diseases other than acute cholecystitis in the third trimester, endoscopic retrograde cholangiopancreatography rather than common bile duct exploration for symptomatic choledocholithiasis, applying the same criteria for emergent surgical intervention in pregnant and non-pregnant IBD patients, utilizing an open rather than minimally invasive approach for pregnant patients requiring emergent surgical treatment of IBD, and managing pregnant patients with active IBD flares in a multidisciplinary fashion at centers with IBD expertise. Graphical abstract

show abstract

“…Unlike previous reports, a higher prevalence of gallstones among men was observed in this study. Several classic epidemiologic studies have reported that pregnancy and female sex hormones place women at a higher risk [3][4][5][6]. The high prevalence of gallstones among men in…”

Section: Plos Onementioning

confidence: 99%

“…A variety of risk factors have been reported to be associated with gallstone formation. Established risk factors for the development of cholesterol gallstones due to enhanced cholesterol synthesis and secretion include genetic background and lifestyle, as well as internal disorders such as aging, female sex, pregnancy, obesity, rapid weight loss, diabetes mellitus, and dyslipidemia [5][6][7][8][9][10]. Predominant risk factors for pigment stones include liver dysfunction [11], Crohn's disease [12], and hyperbilirubinemia due to underlying genetic predisposition [13].…”

Section: Introductionmentioning

confidence: 99%

Risk factors for gallstone disease onset in Japan: Findings from the Shizuoka Study, a population-based cohort study

Higashizono

Nakatani²,

Hawke

et al. 2022

PLoS ONE

View full text Add to dashboard Cite

In the research literature on factors associated with gallstones, large population-based cohort studies are rare. We carried out a study of this type to explore risk factors for the onset of gallstones. This study included Japanese participants aged 40–107 years who were followed prospectively from January 2012 to September 2020 using a dataset composed of two individually linked databases, one containing annual health checkup records and the other containing medical claims for beneficiaries of the National Health Insurance System and the Medical Care System for Elderly in the Latter Stage of Life in Shizuoka Prefecture, Japan. Among the 611,930 participants in the analysis set, 23,843 (3.9%) were diagnosed with gallstones during the observational period (median [max]: 5.68 [7.5] years). Multivariate analysis revealed that risk of gallstone disease was increased by male sex, cerebrovascular disease, any malignancy, dementia, rheumatic disease, chronic pulmonary disease, hypertension, and H. pylori-infected gastritis. These findings provide essential insights into the etiology of cholelithiasis and may contribute to efforts to reduce the incidence of the disease.

show abstract

Gallstones in Pregnancy

Cited by 13 publications

References 0 publications

Risk factors for gallstone disease onset in Japan: findings from the Shizuoka Study, a population-based cohort study

Risk factors for gallstone disease onset in Japan: findings from the Shizuoka Study, a population-based cohort study

SAGES guidelines for the use of laparoscopy during pregnancy

Risk factors for gallstone disease onset in Japan: Findings from the Shizuoka Study, a population-based cohort study

Contact Info

Product

Resources

About