Gambaran Kadar Hemoglobin pada Sediaan Produk Darah Packed Red Cells (PRC) selama Masa Simpan 20 hari

Sepvianti, Wiwit; Wulandari, Meyta; Kusumaningrum, Serafica Btari Christiyani; Sunartono, Sunartono; Djafar, Taib

doi:10.30590/vol6-no2-p123-125

Cited by 2 publications

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“…Produk darah terdiri dari beberapa jenis yaitu darah lengkap (whole blood), sel darah merah pekat (packed red cells), konsentrat trombosit (thrombocyte concentrate) dan plasma darah yang dapat digunakan untuk transfusi darah. Setiap jenis produk darah yang digunakan merujuk pada indikasi medis pasien [3], [4]. Trombosit merupakan bagian terkecil dari unsur seluler sumsum tulang yang sangat penting perannya dalam proses hemostatis dan pembekuan darah.…”

Section: Pendahuluanunclassified

Evaluasi Kualitas Thrombocyte Concentrate (TC) Berdasarkan Kadar pH, Level Kekeruhan, dan Swirling Selama Masa Penyimpanan 5 Hari

Rahman,

Sepvianti,

Tirtana

et al. 2023

JKR

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Thrombocyte concentrate transfusion was one of the important medical treatments in increasing the number of thrombocytes in patients with medical indications of thrombocytopenia. The monitoring of blood product quality from upstream to downstream must be considered in order to obtain a good quality thrombocyte concentrate. Thrombocyte concentrate was prone to change during storage due to significant changes between in vitro and in vivo conditions. The changes in thrombocyte concentrate quality that commonly occur during storage were the decreased platelet levels, increased of acidity (pH) and turbidity, and loss of thrombocyte swirling in the plasma. Therefore, it was necessary to conduct research to determine the quality of thrombocyte concentrates during the 5-day shelf life to find out whether at the end of the shelf life, these blood products were still suitable for transfusion to the patients. Several tools used in this study were Hematology Analyzer, blood scales, and pH meter. The results of successive studies showed that the thrombocyte concentrate product did not meet the basic quality standards because the number of thrombocytes per unit was below the standard that was set by Regulation of the Ministry of Health of the Republic of Indonesia Number 91 Years 2015.

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Section: Pendahuluanunclassified

Evaluasi Kualitas Thrombocyte Concentrate (TC) Berdasarkan Kadar pH, Level Kekeruhan, dan Swirling Selama Masa Penyimpanan 5 Hari

Rahman,

Sepvianti,

Tirtana

et al. 2023

JKR

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“…Produk darah telah resmi ditetapkan sebagai bagian dari komoditi obat sejak tahun 2015, oleh karena itu setiap unit transfusi darah (UTD) yang memproduksi darah saat ini dipantau langsung oleh Badan Pengawas Obat dan Makanan Republik Indonesia (BPOM RI) ( Kementerian Kesehatan, 2015;BPOM, 2018;Sepvianti et al, 2019). Terdapat beberapa jenis produk darah yang diproduksi oleh unit pelayanan darah diantaranya adalah darah lengkap (whole blood), komponen sel darah merah pekat (packed red cells), komponen trombosit (thrombocyte concentrate) dan plasma segar (fresh plasma) (Nur'aini dkk., 2019).…”

Section: Pendahuluanunclassified

“…Dari keseluruhan produk darah yang ada, whole blood dan packed red cells merupakan produk darah yang memiliki komposisi serupa. Akan tetapi, frekuensi penggunaan produk darah whole blood pada transfusi cenderung lebih rendah dibandingkan penggunaan produk darah packed red cells (Artha, 2017;Sepvianti et al, 2019). Hal ini dikarenakan pada produk darah whole blood masih mengandung seluruh komponen darah secara lengkap baik itu eritrosit, leukosit, trombosit maupun plasma dan beberapa faktor pembekuan (Andriyani dkk, 2019), sehingga whole blood menjadi satu-satunya produk darah yang sangat kaya akan leukosit, sedangkan keberadaan leukosit inilah yang banyak dilaporkan sebagai penyebab terjadinya reaksi transfusi.…”

Section: Pendahuluanunclassified

Evaluasi Kualitas Sediaan Packed Red Cells Hasil Pemrosesan Metode Top and Top

Sepvianti

Kusumaningrum²,

Nafilata³

et al. 2022

JI-KES

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ABSTRAKSediaan packed red cells dapat diperoleh melalui beberapa metode pemrosesan di antaranya adalah metode top and top, top and bottom serta leukodepleted. Di antara ketiga metode tersebut metode top and top adalah metode yang paling banyak digunakan di berbagai unit pelayanan darah. Pada penelitian ini dilakukan evaluasi kualitas packed red cells metode top and top dengan parameter uji kadar hemoglobin, residual leukosit, hematokrit dan pH darah. Adapun metode penelitian yang digunakan adalah observasional. Hasil pengujian menunjukkan bahwa rerata kadar hemoglobin diperoleh sebesar 49,02Â±5,51gram/unit, telah melebihi standar minimal hemoglobin yaitu 45gram/ unit. Selaras dengan kadar hemoglobin, kadar hematokrit juga berada pada kisaran ideal 65-75% dengan rerata kadar hematokrit sebesar 70,45Â±5,36%. Nilai pH darah kantong terukur berada pada rentangan 7,348Â±0,064, nilai ini sesuai dengan kriteria packed red cells yang baik yaitu memiliki kadar pH>6,71. Adapun parameter yang belum sesuai dengan standar adalah kadar residual leukosit.Â Packed red cells yang baik seharusnya memiliki residual leukosit <1,2x109sel/unit sedangkan pada penelitian ini diperoleh rerata residual leukosit sebesar (3,66Â±0,41)x109sel/unit yang menunjukkan jumlah leukosit tertinggal masih berada pada jumlah yang cukup banyak. Berdasarkan evaluasi yang dilakukan dapat dinyatakan bahwa packed red cells hasil pemrosesan top and top memiliki kualitas baik dari segi kadar hemoglobin, hematokrit dan pH darah namun kurang baik ditinjau dari level residual leukositnya.Kata kunci: hemoglobin, hematokrit, ph darah, packed red cells, residual leukositABSTRACTPacked red cells(PRC) could be obtained by several processing methods such as top and top, top and bottom and leuko-depleted methods. However, the most widely used method in the blood service unit is the top and top method. Therefore, this research was conducted to evaluate the quality of PRC produced from the top and top method with the haemoglobin level, leukocytes residual, hematocrit, and blood pH parameters. The research method used is observational. In addition, this study was performed to know the QC standard accomplishment. The results showed that the average haemoglobin level was 49,02Â±5,51gram/unit and reached the minimum (45gram/unit).Â The average of hematocrit also reached the minimum standard (65-75%) since it obtainedÂ 70,45Â±5,36%. The pH also had included in the sufficient criteria since it had 7,348Â±0,064, as pH needs to be >6,71. However, the level of the residual leukocyte had not reached the minimum standard yet (1,2x109cells/unit) since the residual leukocytes of PRC in this research were obtained (3,66Â±0,41)x109cells/unit. It showed that there were a high proportion of leukocytes left. Overall, based on the evaluation, it was concluded that the PRC produced from the top and top method had better quality in the haemoglobin level, hematocrit, and pH but not in the residual leukocyte level.Â Keywords: hemoglobin, hematocrit, blood pH, packed red cells, residual leukocytes Â

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Gambaran Kadar Hemoglobin pada Sediaan Produk Darah Packed Red Cells (PRC) selama Masa Simpan 20 hari

Cited by 2 publications

References 0 publications

Evaluasi Kualitas Thrombocyte Concentrate (TC) Berdasarkan Kadar pH, Level Kekeruhan, dan Swirling Selama Masa Penyimpanan 5 Hari

Evaluasi Kualitas Thrombocyte Concentrate (TC) Berdasarkan Kadar pH, Level Kekeruhan, dan Swirling Selama Masa Penyimpanan 5 Hari

Evaluasi Kualitas Sediaan Packed Red Cells Hasil Pemrosesan Metode Top and Top

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