Gambir Extract (Uncaria Gambir) Decreases Inflammatory Response and Increases Gastric Mucosal Integrity in Wistar Rats - Model Gastritis

Oswari, Liniyati D; Hidayat, Rachmat; Fatmawati, Fatmawati; Hayati, Lusia; Alisa, Bella Safira

doi:10.3889/oamjms.2019.758

Cited by 10 publications

(6 citation statements)

References 21 publications

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“…14 In dental practice, clove oil, gambir, jatropha, sidaguri and bee venom have been usually used to relieve dental pain by applying them directly to the affected tooth. [4][5][6][7] A preliminary in vitro study in an animal model with periapical lesion showed that the root of sidaguri was able to decrease C-reactive protein level (CRP), one of many molecules that take part in the acute inflammatory process. 8 Another study showed that root of sidaguri was a non-selective COX inhibitor, an enzyme involved in the synthesis of prostaglandin E2.…”

Section: Discussionmentioning

confidence: 99%

Effect of sidaguri and jatropha on tooth microhardness and tooth surface: An in vitro evaluation using CLSM

Tanumiharja¹,

Natsir²,

Mattulada³

et al. 2021

J Dentomaxillofac Sci

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Objective:The purpose of this study was to evaluate the effect of herbal alternatives, extract of sidaguri (sida rhombifolia) combine with extract of jatropha sap (jatropha curcas) application on microhardness and morphology of tooth surface. Material and Methods: Twelve upper first premolar teeth were used in this study, prepared to Class I box cavities, and were then allocated into 4 groups (n=3). Group 1-3 were treated groups, applied with combined extracts of a small dose (5 mg), medium dose (25 mg), and high dose (50 mg), while group 4 was the control group. The cavities were restored with composite resin, immersed in artificial saliva, and stored at room temperature for 14 days. The fillings and extracts were removed and cleaned under running tap water. The teeth were cut in a vertical direction towards the apex, sectioned into 1 mm thickness, and evaluated using Laser Scanning Microscope (LSM), then were examined for microhardness test. Results: All treated groups showed significantly lower microhardness than the control group. Tooth porosity was observed, and its extensiveness was affected by doses of extracts. Conclusion:The application of herbal alternatives (extract of sidaguri and jatropha) lowered the microhardness of tooth structure and caused tooth porosities.

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Section: Discussionmentioning

confidence: 99%

Effect of sidaguri and jatropha on tooth microhardness and tooth surface: An in vitro evaluation using CLSM

Tanumiharja¹,

Natsir²,

Mattulada³

et al. 2021

J Dentomaxillofac Sci

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“…is an Indonesian plant that contains flavonoids, especially catechins (40%-80% of the dry extract weight), procyanidin B1, procyanidin B3, and gambirin (1%), and (-)-epicatechin (1.5%). Gambir is reported to have antibacterial, antiseptic, antioxidant, and antiinflammatory properties (Dewi et al, 2018;Oswari et al, 2019;Melia et al, 2015;Ningsih and Rahayuningsih, 2019). In animal models of liver fibrosis using white rats (Rattus norvegicus L.) induced by the hepatotoxic compound carbon tetrachloride (CCl 4 ), the gambir extract showed potency as a hepatoprotector (Fahrudin et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Structure-based screening of inhibitor platelet-derived growth factor from ethanol extract of Uncaria gambir (Hunter) Roxb. as an antifibrotic in keloid fibroblast cells

Jusman¹,

Amalia²,

Paramita³

et al. 2022

J App Pharm Sc

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This study aimed to determine the potency of the compounds in gambir [Uncaria gambir (Hunter) Roxb.] to inhibit the proliferation of keloid fibroblasts using an in silico study with molecular docking and an in vitro assay. In this study, the interaction between compounds found in the gambir plant and platelet-derived growth factor subunit A (PDGF-α) as the target protein and the percentage inhibition were analyzed to determine its potential as a candidate for herbalbased keloid therapy. The compounds found in the plant gambir [(+)-catechin, gambirin A1, gambirin A2, gambirin B1, gambirin B2, gambirin C, procyanidin B1, procyanidin B2, epigallocatechin gallate, and (+)-epicatechin] were docked to the target protein PDGF-α (PBD ID: 3MJK). An MTT assay was conducted to determine the cytotoxicity of each compound. The three compounds gambirin A1, procyanidin B2, and neooxygambirtannine had the best affinity values 10.218, and 9.129, respectively. The IC 50 of the ethanolic extract of gambir was 22.40 ± 0.071 ug/ml against keloid fibroblast cells. The potential bioactive compounds as PDGF inhibitors have been identified, namely, gambirin A1, procyanidin B2, and neooxygambirtannine. These compounds can be isolated for further research. IC 50 can be used to understand the molecular mechanism of the inhibition of the gambir extract against keloid fibroblast cells.

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“…Previous studies have reported catechu from Uncaria gambir Roxb. It possesses antioxidant [ 11 ], anti-inflammatory [ 12 ], and antimicrobial activities [ 13 ]. Unsurprisingly, the aforementioned biological activities of catechu mainly result from catechin and epicatechin [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Herbal Extracts of Catechu from Uncaria gambir in the Treatment of Chronic Diabetic Wounds

Tsai

Hsieh

et al. 2022

Pharmaceuticals

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Catechu is a dried decoction from twigs with the leaves of Uncaria gambir. Its antioxidant, anti-inflammatory, and antimicrobial activities have been previously reported because of its high catechin and epicatechin content (>21%). It is also one of the components used in traditional Chinese herbal medicine, “Jinchuang Ointment,” which has excellent efficacy in treating chronic diabetic wounds. An in vivo zebrafish embryo platform and an in vitro cell-based tube formation assay were used to measure the angiogenic activity of catechu extracts. Interestingly, for the first time, catechu extracts stimulated angiogenic activity on both platforms. The expression of the IL-8 gene was induced in HMEC1 cells after treatment with catechu extracts for 1 h only. In contrast, the upregulation of FGFR2, FGFR3, NF-κB, STAT3, and vimentin persisted for 24 h. A summary of the possible mechanisms underlying the angiogenic activity of catechu extracts in HMEC1 cells is shown. Unexpectedly, catechu extracts inhibited the migration of HaCaT cells. These results can account for the intense blood flow flux in porcine excisional wound sites in our previous studies, which provides insights into the therapeutic activity of catechu extract in chronic diabetic wounds.

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Gambir Extract (Uncaria Gambir) Decreases Inflammatory Response and Increases Gastric Mucosal Integrity in Wistar Rats - Model Gastritis

Cited by 10 publications

References 21 publications

Effect of sidaguri and jatropha on tooth microhardness and tooth surface: An in vitro evaluation using CLSM

Effect of sidaguri and jatropha on tooth microhardness and tooth surface: An in vitro evaluation using CLSM

Structure-based screening of inhibitor platelet-derived growth factor from ethanol extract of Uncaria gambir (Hunter) Roxb. as an antifibrotic in keloid fibroblast cells

Role of Herbal Extracts of Catechu from Uncaria gambir in the Treatment of Chronic Diabetic Wounds

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