Gamma knife radiosurgery in skull base meningiomas: a possible relationship between somatostatin receptor decrease and early neurological improvement without tumour shrinkage at short-term imaging follow-up

Abstract

Our preliminary findings suggest a possible relationship between a decrease in the concentration of SRs on meningioma cells at short-term functional imaging follow-up after radiosurgery and early neurological improvement.

Angiomatous Meningioma Presenting with Depression: A Case Report and Literature Review

“…It has been shown that gamma-knife stereotactic surgery does not increase the probability of malignant transformation of meningiomas [10]. Radiotherapy has an important role in causing tumor shrinkage since it inhibits the expression of VEGF and somatostatin receptors, which causes blood vessel contraction [11]. Multiple studies have proved that radiotherapy reduces the recurrence rates of these tumors [1].…”

Intracranial Angiomatous Meningioma: Case Report and Literature Review

“…The molecular basis of the effectiveness of radiation therapy is that radiotherapy can inhibit the expression of vascular endothelial growth factor (VEGF) and somatostatin receptor, which causes blood vessel contraction to reduce blood supply and then shrink the tumor [7]. Nicolato A et al reported that, in the 122 cases of cavernous sinus meningiomas who received gamma-knife stereotactic radiosurgery, 118 (97%) cases had stable clinical symptoms or greatly improved [8]. Subach et al think that patients with residual tumor, recurrent tumors, or tumor progression after subtotal resection, and inoperable patients, can receive the radiosurgery [9].…”

Radiosurgical Treatment of Intracranial Meningiomas: Update 2011

“…A major role to this regard has been played by image co-registration, morpho-functional integration (functional MRI / spectroscopy, specific metabolic PET scan mapping etc.) on one side, and by the use of "hybrid shots" with the new "Perfexion" whenever dealing with crucial targeting (7,36,50,57,58,66). 2. the introduction of dedicated algorhitms accurately "driving" the dose planning system, with probabilistic models including stockastic monitoring, quadrature-sum analysis (20) and linear-quadratic formalisms (32).…”

“…Inactivation/destruction of hormonal receptors (e.g. Octreotide-r) (57,58). Moreover, it should be stressed that meningiomas located in highly vascularized-oxygenated regions of the brain (cavernous sinus, sagittal sinus etc), due to still poorly known mechanisms (e.g.…”