Gamma-M deficiency predisposing to meningococcal septicaemia.

Hobbs, J. R.; Milner, R. D. G.; Watt, P. J.

doi:10.1136/bmj.4.5579.583

Cited by 140 publications

(67 citation statements)

References 8 publications

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“…The most common presentation is recurrent and chronic upper and lower respiratory tract infections and sepsis [2][3][4][5]23]. B cells, T cells and T cell subsets, and NK cells are normal [5,15,[21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

“…Selective IgM deficiency can be asymptomatic or may symptomatically present with infections from encapsulated bacteria and viruses, some of which can be serious and even lifethreatening infections varying from pneumonia to septicemia and meningitis [2][3][4]. Hobbs et al, [3] first described selective IgM deficiency in 2 children with fulminant meningococcus septicemia. We described an adult patient with primary selective IgM deficiency who presented with disseminated sepsis and invasive aspergilosis [5].…”

Section: Introductionmentioning

confidence: 99%

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Selective IgM Deficiency with T Cell Defects and Mycobacterium Avium Complex (MAC) Infection

Gupta¹

2012

TOIJ

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Primary selective IgM deficiency in adults is associated with normal T cell function, and patients clinically manifest with recurrent pyogenic bacterial infections. In this study, we present three patients with selective IgM deficiency with significant defects in T cells and NK cell cytotoxicity, and Mycobacterial avium intracellulare (MAC) infection. T cell defect is characterized by markedly reduced numbers of T cells and T cell subsets, decreased T cell proliferative responses to mitogens and antigens, including PPD, and significantly decreased production of IFN-; however, expression of IFN-receptors is normal. We propose that selective IgM deficiency with significant T cell functional defects might represent a distinct clinical entity, which is associated with increased susceptibility to MAC infection.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Selective IgM Deficiency with T Cell Defects and Mycobacterium Avium Complex (MAC) Infection

Gupta¹

2012

TOIJ

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“…Individuals with IgM deficiency appear at risk of disseminated meningococcal disease [22,23]. It has been demonstrated that locally produced IgM in IgA-deficient patients exhibits anti-virus activity [24].…”

Section: Total Iga Igg and Igm Antibodies Of Secretors And Non-secrementioning

confidence: 99%

Secretor status and humoral immune responses to Neisseria lactamica and Neisseria meningitidis

Zorgani¹,

Stewart²,

Blackwell³

et al. 1992

Epidemiol. Infect.

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SUMMARYNon-secretors of ABO blood group antigens are over-represented among patients with meningococcal diseases. Lower levels of secretory IgA reported for non-secretors have been suggested to compromise mucosal defences. Total serum and salivary IgG, IgA and IgM and levels of these isotypes specific for Neisseria lactamica and five isolates of meningococci were determined by ELISA for 357 pupils and staff of a secondary school in which an outbreak of meningitis occurred. There were no differences in total or specific levels of serum IgG, IgA or IgM or salivary IgG or IgA of secretors compared with non-secretors. Non-secretors had significantly lower levels of salivary IgM (P = 0022) A similar pattern was observed for levels of IgM specific for N. lactamica and five meningococcal isolates. The significance of these results is discussed with reference to the role of secretory IgM in protection of mucosal surfaces in infants.

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“…Low levels of IgM associated with both meningitis and disseminated non-progressive vaccinia have been reported and require further analysis (Hobbs, Milner & Watt, 1967). Low levels of circulating IgE associated with recurrent respiratory disease have also been described.…”

Section: Measurements Ofserum Immunoglobulin Concentrationmentioning

confidence: 99%

Primary Immunodeficiencies

Parkman¹

2005

Measuring Immunity

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Gamma-M deficiency predisposing to meningococcal septicaemia.

Cited by 140 publications

References 8 publications

Selective IgM Deficiency with T Cell Defects and Mycobacterium Avium Complex (MAC) Infection

Selective IgM Deficiency with T Cell Defects and Mycobacterium Avium Complex (MAC) Infection

Secretor status and humoral immune responses to Neisseria lactamica and Neisseria meningitidis

Primary Immunodeficiencies

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