Gamma-oryzanol prevents ethanol-induced liver injury by ameliorating oxidative stress and modulating apoptosis-related protein expression in mice

Zhu, Lijuan; Xiang, Siting; Ou, Zhaoping; Ma, Chaoyang; Yi, Xianglian; Huang, Lin; Ma, Yurong; Liang, Zengenni; Yuan, Zhihang; Wen, Lixin; Li, Rongfang; Wu, Jing; Tan, Zhuliang; Yi, Jine

doi:10.1016/j.jff.2019.103532

Cited by 14 publications

(13 citation statements)

References 61 publications

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“…Long-term heavy drinking can cause ALD, which is characterized by liver inflammation and imbalance of gut microbiota (Wrzosek et al, 2021). The process of alcohol metabolism and its derivatives could induce the body's inflammatory responses, oxidative stress, and nutritional imbalance (Zhu et al, 2019). In recent years, more and more studies have shown that the gut microbiota is an important participant in the occurrence and development of ALD by acting through the gut-liver axis and the gut-brain axis (Lim et al, 2017;Tripathi et al, 2018;Bajaj, 2019).…”

Section: Discussionmentioning

confidence: 99%

Intake of Bifidobacterium lactis Probio-M8 fermented milk protects against alcoholic liver disease

Yang

Kang³

et al. 2022

Journal of Dairy Science

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Alcoholic liver disease (ALD) is a liver disease caused by long-term heavy drinking, which is characterized by increased inflammation and oxidative stress in the liver and gut dysbiosis. The purpose of this study was to investigate the protective effect of administering ordinary and probiotic-(containing the Bifidobacterium animalis ssp. lactis Probio-M8 strain; M8) fermented milk to rats. Several biochemical parameters and the fecal metagenomes were monitored before (d 0) and after (d 42) the intervention. Our results confirmed that alcohol could cause significant changes in the liver levels of the proinflammatory cytokine IL-1β, antioxidation indicators, and liver function-related indicators; meanwhile, the gut bacterial and viral microbiota were disrupted with significant reduction in microbial diversity and richness. Feeding the rats with Probio-M8-fermented milk effectively maintained the gut microbiota stability, reduced liver inflammation and oxidative stress, and mitigated liver damages in ALD. Moreover, the Probio-M8-fermented milk reversed alcohol-induced dysbiosis by restoring the gut microbiota diversity, richness, and composition. Four predicted fecal metabolites (inositol, tryptophan, cortisol, and vitamin K2) increased after the intervention, which might help regulate liver metabolism and alleviate ALD-related symptoms. In short, our data supported that consuming Probio-M8-fermented milk effectively mitigated ALD. The protective effect against ALD could be related to changes in the gut microbiome after probiotic-fermented milk consumption. However, such observation and the causal relationship among probiotic milk consumption, changes in gut microbiome, and disease alleviation would still need to be further confirmed. Nevertheless, this study has shown in a rat model that consuming probiotic-fermented milk could protect against ALD.

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Section: Discussionmentioning

confidence: 99%

Intake of Bifidobacterium lactis Probio-M8 fermented milk protects against alcoholic liver disease

Yang

Kang³

et al. 2022

Journal of Dairy Science

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“…Diets rich in SFA increase liver fat accumulation compared with those rich in PUFAs or MUFAs, but vitamin E supplementation reduces this accumulation 82 . Additionally, the accumulation of squalene in the liver reduces local cholesterol and triglyceride concentrations, 38 and γ‐oryzanol reduces hepatic steatosis and protects against ethanol‐induced liver injury by alleviating oxidative stress in mice 83 . Finally, phytosterols are natural ingredients that protect against non‐alcoholic fatty liver disease by regulating lipid metabolism and inhibiting liver inflammation 84 .…”

Section: Discussionmentioning

confidence: 99%

Beneficial effects of monounsaturated fatty acid‐rich blended oils with an appropriate polyunsaturated/saturated fatty acid ratio and a low n‐6/n‐3 fatty acid ratio on the health of rats

Yang

Chu

et al. 2022

J Sci Food Agric

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BACKGROUND The effects of dietary fat on health are influenced by its fatty acid profile. We aimed to determine the effects of monounsaturated fatty acid (MUFA)‐rich blended oils (BO) containing a balance of polyunsaturated fatty acids (PUFAs) and saturated fatty acids (SFAs) and with a low n‐6/n‐3 PUFA ratio on the health of rats fed normal or high‐fat diets. The BO was obtained by mixing red palm oil, rice bran oil (RO), tea seed oil and flaxseed oil in appropriate proportions. RESULTS BO consumption reduced the serum low‐density lipoprotein cholesterol (LDL‐C), non‐esterified fatty acid (NEFA), insulin (INS), tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6), interleukin‐1 (IL‐1), high‐sensitivity C‐reactive protein (hs‐CRP), malondialdehyde (MDA), lipid peroxide (LPO) and oxidized LDL (ox‐LDL) concentrations and the homeostasis model assessment of insulin resistance (HOMA‐IR); it increased the high‐density lipoprotein cholesterol (HDL‐C), glutathione peroxidase (GSH‐Px) and superoxide dismutase (SOD) concentrations, and the bone mineral density (BMD) versus control oil‐containing normal and high‐fat diets. BO also reduced the triglyceride (TG), hs‐CRP, MDA, ox‐LDL and reactive oxygen species (ROS) concentrations; and increased the serum HDL‐C and SOD, and BMD versus RO‐containing high‐fat diets. Finally, BO reduced the glucose (GLU) and INS, and HOMA‐IR; it increased HDL‐C, SOD, femoral weight and BMD versus RO‐containing normal diets. CONCLUSION BOs with an appropriate fatty acid profile have beneficial effects on the glucolipid metabolism, inflammation, oxidative stress and bone quality of rats when included in both normal and high‐fat diets. © 2022 Society of Chemical Industry.

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“…As an antioxidant, GO has been applied to ameliorate oxidative stress in lung and liver. 21,24 It also exerts anxiolytic effects under high-fat diet and chronic stress circumstances. 17,18 The anti-inflammatory effect of Oryzanol is reported in glaucoma.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of Gamma Oryzanol on distant organs after kidney ischemia-reperfusion in rats: A focus on liver protection

et al. 2020

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Background: Acute kidney injury (AKI) is the main clinical concern resulted from ischemia-reperfusion injury (IRI). Ample clinical data indicates that AKI is associated with distant organ dysfunctions and poor patients’ outcomes. Oxidative stress and inflammation have a critical role in the pathogenesis of organ injuries following IRI. The objectives of this study were to determine the impact of Gamma Oryzanol (GO), extracted from rice bran oil, on distant organs in rats after IRI. Methods: Twelve out of 24 Wistar rats were treated by one dosage of GO (100mg/kg) 1 h before I/R induction through both oral gavage and intraperitoneal injection. Then, the AKI model rats were induced by IRI. Oxidative stress and antioxidant protein levels were assessed in the brain, heart, and liver tissues in the experimental groups. Furthermore, the effects of GO on IRI-induced liver dysfunction, apoptosis, and inflammation were measured by Western blot. Results: GO pretreatment could significantly restore the levels and activity of antioxidant proteins in the brain, heart, and liver tissues (P < 0.05). Moreover, GO pretreatment could decrease the inflammatory cytokine (IL-1, IL-6, and TNF-α) in the liver (P < 0.01). By reducing Bax/Bcl-2 ratio and down-regulating caspase-3, GO could significantly diminish apoptosis in the liver tissue after the kidney I/R (P < 0.01). Additionally, GO could significantly diminish the deterioration of liver function in the kidney I/R model. Conclusion: GO protects distant organs against renal IRI-induced oxidative stress. Furthermore, it ameliorates liver function and remarkably exerts anti-oxidative, anti-inflammatory, and anti-apoptotic roles in the liver as an important detoxifying organ.

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Gamma-oryzanol prevents ethanol-induced liver injury by ameliorating oxidative stress and modulating apoptosis-related protein expression in mice

Cited by 14 publications

References 61 publications

Intake of Bifidobacterium lactis Probio-M8 fermented milk protects against alcoholic liver disease

Intake of Bifidobacterium lactis Probio-M8 fermented milk protects against alcoholic liver disease

Beneficial effects of monounsaturated fatty acid‐rich blended oils with an appropriate polyunsaturated/saturated fatty acid ratio and a low n‐6/n‐3 fatty acid ratio on the health of rats

Protective effects of Gamma Oryzanol on distant organs after kidney ischemia-reperfusion in rats: A focus on liver protection

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