Gamma-poly glutamate/gelatin composite hydrogels crosslinked by proanthocyanidins for wound healing

Liu, W. C.; Wang, Huey‐Yuan; Lee, Tsung-Han; Chung, Ren‐Jei

doi:10.1016/j.msec.2019.04.018

Cited by 50 publications

(22 citation statements)

References 50 publications

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“…Since the drug was loaded into the particles the higher the amount of particles the higher the amount of drug was loaded into the fabric. It is believed that the drug not only loaded into meso and nano pores of the HAp particles but also the whole surface of the particles are coated with the drug with similar mechanisms reported in the literature [25,26].…”

Section: Hap Particle Embedment Capacity Of Cotton Fabric and The Effsupporting

confidence: 59%

Novel slow drug release bioceramic composite materials for wound dressing applications: potential of natural materials

Macha

Sultan

2020

SN Appl. Sci.

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There is a need for friendly and affordable wound dressing materials capable of uptaking and releasing active clinical agents. Proper combinations of materials that could quickly release antibiotics at the beginning, then slow and controlled release with time would make excellent materials for wound care management. In this study, cotton handwoven fabric hydroxyapatite (derived from coralline skeletons) polylactic acid composites were developed. The developed composites were characterized in terms of their physical and mechanical properties. Also, the in vitro drug release profiles for the developed composites were established. Bacteria efficacy of natural antimicrobial agents loaded composites against gram-positive bacteria Staphylococcus aureus (S. aureus) was also studied. The results suggested that the hand-weaving method has the potential to control the porosity of the fabric for different applications. Woven fabric with 1 mm pore sizes is suggested to have better particle uptake properties and moderate mechanical and physical properties suitable for wound dressing applications. Particle embedment capacity (w/w %) seemed to increase as the fabric pore sizes increases. On the other hand fabric with 1 mm pore sizes uptakes the highest amount of particles (0.174 g). A combination of coralline derived hydroxyapatite particles with cotton fabric suggested controlling the drug release rate by 30% compared with the fabric without the particles, appropriate for prolonged drug release applications. The released drug and natural antimicrobial agents from the developed composites suggested inhibiting microbial growth in which honey performed close to a clinical antibiotic. It was recommended to conduct an in vivo study for the developed composite.

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Section: Hap Particle Embedment Capacity Of Cotton Fabric and The Effsupporting

confidence: 59%

Novel slow drug release bioceramic composite materials for wound dressing applications: potential of natural materials

Macha

Sultan

2020

SN Appl. Sci.

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“…Presently, optimizing the performance of hydrogels seems to be an inevitable tendency and requires the joint efforts of researchers. In addition, synthesized materials are also diverse, including alcohols, acrylics, and their derivatives such as poly vinyl alcohol (PVA), 58 poly caprolactone (PCL), 59 polyethylene glycol (PEG), 60 poly lactic acid (PLA), 61 poly glycolic acid (PGA), 62 and poly lactic‐co‐glycolic acid (PLGA) 63 . Interestingly, these polymers are often combined with one another or with other substances to form a composite hydrogel for desirable properties.…”

Section: The Classification Preparation Of Hydrogel and Its Advantamentioning

confidence: 99%

Advances and trends of hydrogel therapy platform in localized tumor treatment: A review

Tan

Huang

et al. 2020

J Biomedical Materials Res

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Due to limitations of treatment and the stubbornness of infiltrative tumor cells, the outcome of conventional antitumor treatment is often compromised by a variety of factors, including severe side effects, unexpected recurrence, and massive tissue loss during the treatment. Hydrogel‐based therapy is becoming a promising option of cancer treatment, because of its controllability, biocompatibility, high drug loading, prolonged drug release, and specific stimuli‐sensitivity. Hydrogel‐based therapy has good malleability and can reach some areas that cannot be easily touched by surgeons. Furthermore, hydrogel can be used not only as a carrier for tumor treatment agents, but also as a scaffold for tissue repair. In this review, we presented the latest researches in hydrogel applications of localized tumor therapy and highlighted the recent progress of hydrogel‐based therapy in preventing postoperative tumor recurrence and improving tissue repair, thus proposing a new trend of hydrogel‐based technology in localized tumor therapy. And this review aims to provide a novel reference and inspire thoughts for a more accurate and individualized cancer treatment.

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“…However, some natural polyphenols are used as components of HGs for purposes different from the bioproperties mentioned before. For example, OPC were examined as a natural cross-linking reagent to make poly-γ-glutamic acid/gelatin (γ-PGA)/G) HGs, able to accelerate wound contraction and re-epithelialization in an in vivo wound healing model in rats [ 60 ].…”

Section: Potential Biomedical Applications Of (Poly)phenols Loadedmentioning

confidence: 99%

Hydrogels for the Delivery of Plant-Derived (Poly)Phenols

et al. 2020

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This review deals with hydrogels as soft and biocompatible vehicles for the delivery of plant-derived (poly)phenols, compounds with low general toxicity and an extraordinary and partially unexplored wide range of biological properties, whose use presents some major issues due to their poor bioavailability and water solubility. Hydrogels are composed of polymeric networks which are able to absorb large amounts of water or biological fluids while retaining their three-dimensional structure. Apart from this primary swelling capacity, hydrogels may be easily tailored in their properties according to the chemical structure of the polymeric component in order to obtain smart delivery systems that can be responsive to various internal/external stimuli. The functionalization of the polymeric component of hydrogels may also be widely exploited to facilitate the incorporation of bioactive compounds with different physicochemical properties into the system. Several prototype hydrogel systems have been designed for effective polyphenol delivery and potential employment in the treatment of human diseases. Therefore, the inherent features of hydrogels have been the focus of considerable research efforts over the past few decades. Herein, we review the most recent advances in (poly)phenol-loaded hydrogels by analyzing them primarily from the therapeutic perspective and highlighting the innovative aspects in terms of design and chemistry.

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Gamma-poly glutamate/gelatin composite hydrogels crosslinked by proanthocyanidins for wound healing

Cited by 50 publications

References 50 publications

Novel slow drug release bioceramic composite materials for wound dressing applications: potential of natural materials

Novel slow drug release bioceramic composite materials for wound dressing applications: potential of natural materials

Advances and trends of hydrogel therapy platform in localized tumor treatment: A review

Hydrogels for the Delivery of Plant-Derived (Poly)Phenols

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