Gamma‐Tocotrienol Attenuates the Hepatic Inflammation and Fibrosis by Suppressing Endoplasmic Reticulum Stress in Mice

Kim, Yongeun; Natarajan, Sathish Kumar; Chung, Soonkyu

doi:10.1002/mnfr.201800519

Cited by 25 publications

(47 citation statements)

References 54 publications

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“…Perhaps, TRF caused more in ammation reduction in visceral WAT and other tissues. Our results are in line with previous reports of the anti-in ammatory effect of TRF but do not con rm some previous studies about the inhibitory effect of gT3 on ER stress (16,29). These studies evaluated the effect of pure gT3 on hepatic ER stress which possibly exerts stronger effects than TRF does.…”

Section: Discussionsupporting

confidence: 74%

“…In this regard, Gregor et al showed that weight loss reduced ER stress and GRP78 in obesity (9). Moreover, a growing body of evidence has focused on functional foods with anti-in ammatory properties (15,16).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, anti-in ammatory activities are proposed for tocotrienols (T3), an important part of vitamin E family (20)(21)(22). Kim et al study demonstrated the effect of T3 on hepatic in ammation by modulating ER stress (16). However, up to the best of our knowledge, the potential inhibitory impacts of RJ and T3 on ER stress in the hypothalamus, as a regulatory tissue, and adipose tissues, as important sites balancing cytokine secretion, have not been assessed yet.…”

Section: Introductionmentioning

confidence: 99%

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The effect of royal jelly and tocotrienol-rich fraction along with calorie restriction on hypothalamic endoplasmic reticulum stress and adipose tissue inflammation in diet-induced obese rats

Irandoost

Alamdari

Saidpour

et al. 2020

Preprint

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Objectives: Endoplasmic reticulum (ER) stress causes adipose tissue dysfunction and chronic inflammation in obesity. Royal jelly (RJ) and tocotrienol-rich fraction (TRF) are reported to ameliorate inflammation. However, the improving effects of RJ and TRF on inflammation from ER stress modulating view have not been assessed so far. Hence, we investigated the effect of RJ and TRF on ER stress and some adipose tissue-derived inflammatory markers in the high-fat diet (HFD)-induced obesity. Wistar obese rats randomly allocated into 5 groups: HFD, calorie restriction diet (CRD), RJ+CRD, TRF+CRD, RJ+TRF+CRD. After 8-week intervention, adipose tissues and hypothalamus were dissected and serum was collected. Results: RJ reduced glucose-regulated protein-78 (GRP78) expression as ER stress indicator in WAT and hypothalamus compared to CRD. Besides, RJ diminished the expression of inflammatory markers in white adipose tissue (WAT) and also decreased the serum concentration of them. TRF reduced inflammatory markers in the serum without remarkable effects on ER stress. Overall, RJ has protective effect against adipose tissue dysfunction and inflammation then suggested as a therapeutic approach to reduce some obesity-related complications. The impact of TRF in this regard is lower than RJ and limited to systemic inflammation improvement without remarkable changes in adipose tissue inflammation.

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Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effect of royal jelly and tocotrienol-rich fraction along with calorie restriction on hypothalamic endoplasmic reticulum stress and adipose tissue inflammation in diet-induced obese rats

Irandoost

Alamdari

Saidpour

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…In this regard, Gregor et al have shown that weight loss reduce ER stress and GRP78 as its marker in obesity (9). Moreover, a growing body of evidence has focused on functional foods with anti-in ammatory properties (15,16).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Royal Jelly and Tocotrienol-rich Fraction Along With Calorie Restriction on Hypothalamic Endoplasmic Reticulum Stress and Adipose Tissue Inflammation in Diet-induced Obese Rats

Irandoost

Alamdari

Saidpour

et al. 2020

Preprint

View full text Add to dashboard Cite

Abstract Objectives Endoplasmic reticulum (ER) stress causes adipose tissue dysfunction and chronic inflammation in obesity. Royal jelly (RJ) and tocotrienol-rich fraction (TRF) are reported to ameliorate inflammation. However, the improving effects of RJ and TRF on inflammation from ER stress modulating view have not been assessed so far. Hence, we investigated the effect of RJ and TRF on ER stress and some adipose tissue-derived inflammatory markers in the high-fat diet (HFD)-induced obesity. Wistar obese rats randomly allocated into 5 groups: HFD, calorie restriction diet (CRD), RJ + CRD, TRF + CRD, RJ + TRF + CRD. After 8-week intervention, adipose tissues and hypothalamus were dissected and serum was collected. Results RJ reduced glucose-regulated protein-78 (GRP78) expression as ER stress indicator in WAT and hypothalamus compared to CRD. Beside RJ diminished the expression of inflammatory markers in white adipose tissue (WAT) and also decreased the serum concentration of them. TRF reduced inflammatory markers in the serum of obese rats but the effect of TRF on ER stress was not remarkable. Overall, RJ decreased WAT and hypothalamic ER stress and diminished secretion of inflammatory markers of WAT in obesity. Thereby RJ has protective effect against adipose tissue dysfunction and inflammation then suggested as a therapeutic approach to reduce some obesity-related complications.

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“…Alphatocopherol is the main form in supplements which has been widely studied. Accumulating evidence suggests that γ-tocotrienol has potential cardiovascular and metabolic health-promoting properties [12], while the biological efficiencies of other isoforms are not established.…”

mentioning

confidence: 99%

Plasma omega-3 polyunsaturated fatty acid and tocopherol statuses and their relationships with aging-related diseases

Liu¹,

Liu²,

Chen³

et al. 2020

Preprint

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Background: The beneficial effects of omega-3 polyunsaturated fatty acids (PUFAs) and tocopherols remain controversial. This study was conducted to examine the plasma levels of different analogues of omega-3 PUFAs and tocopherols, and to evaluate their relationships with aging-related diseases. Methods: 136 consecutive men with the median age of 70 (ranging from 50 to 97) years old were recruited. Plasma eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), α-, γ-, and δ-tocopherol were measured by liquid chromatography mass spectrometry. Results: Plasma omega-3 PUFAs were positively correlated with α- and γ-tocopherol (p<0.01), while the relationships between omega-3 PUFAs and δ-tocopherol were not significant (p>0.05). Increasing age was the most profound risk factor for coronary artery disease (CAD), carotid atherosclerosis (CAS), hypertension and these comorbidities (p<0.01). Age had positive associations with certain atherosclerotic parameters, including carotid intima-media thickness (p=0.046), carotid artery plague area (p<0.001) and brachial-ankle pulse wave velocity (p<0.001). In these observed isoforms, only γ-tocopherol had a mild inverse correlation with age (p=0.002). High plasma α-tocopherol concentration served as a potential protective factor for CAD (odds ratio [OR] 0.65; 95% CI 0.48-0.89; p=0.006), and was inversely associated with maximum systolic internal carotid artery (ICA) velocity (p=0.011). Plasma DHA concentration was negatively associated with carotid artery plague area (p=0.028) and ICA velocity (p=0.006), while its correlations with atherosclerosis diseases, including CAD and CAS, were not significant (p>0.05). Conclusions: Age is positively correlated with atherosclerosis, hypertension and comorbidities. Alpha-tocopherol may be a protective factor for atherosclerosis, while the correlations between omega-3 PUFAs and atherosclerosis were not significant.

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Gamma‐Tocotrienol Attenuates the Hepatic Inflammation and Fibrosis by Suppressing Endoplasmic Reticulum Stress in Mice

Abstract: γT3 supplementation is effective in attenuating NAFLD and fibrosis through a synergistic mechanism of decreased DNL and hepatic ER stress. This work strongly supports the translational potential of γT3 supplementation against NAFLD.

Cited by 25 publications

References 54 publications

The effect of royal jelly and tocotrienol-rich fraction along with calorie restriction on hypothalamic endoplasmic reticulum stress and adipose tissue inflammation in diet-induced obese rats

The effect of royal jelly and tocotrienol-rich fraction along with calorie restriction on hypothalamic endoplasmic reticulum stress and adipose tissue inflammation in diet-induced obese rats

The Effect of Royal Jelly and Tocotrienol-rich Fraction Along With Calorie Restriction on Hypothalamic Endoplasmic Reticulum Stress and Adipose Tissue Inflammation in Diet-induced Obese Rats

Plasma omega-3 polyunsaturated fatty acid and tocopherol statuses and their relationships with aging-related diseases

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