Gancao-Gansui combination impacts gut microbiota diversity and related metabolic functions

Yu, Jin-Gao; Guo, Jianming; Tao, Weiwei; Liu, Pei; Shang, Erxin; Zhu, Zhenhua; Fan, Xiu-He; Shen, Juan; Hua, Yongqing; Zhu, Kevin Y.; Tang, Yuping; Duan, Jin‐Ao

doi:10.1016/j.jep.2017.11.031

Cited by 43 publications

(27 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, we observed significant differences in gut microbiota communities between the ND group and HFD group. At the phyla level, the gut of HFD-fed mice was characterized by increased abundance of Firmicutes and Proteobacteria, decreased abundance of Bacteroidales, as well as increased ratio of F/B, the profiling of which appeared similar to previously reported "obese gut" (Alard et al, 2016;Yu et al, 2018;Zhang et al, 2019b) and obesity-driven gut dysbiosis (Anhe et al, 2019;Jeong et al, 2019). In general, both Firmicutes and Bacteroidales are relevant with energy metabolism homeostasis (Ley et al, 2005).…”

Section: Discussionsupporting

confidence: 61%

“…Chinese herbal medicine has shown powerful capacity of improving both obesity and its metabolic diseases through the regulation of gut microbiota (Hasani-Ranjbar et al, 2009). Indeed, as gut microbiota composition is essential for the occurrence of obesity, varieties of bioactive substances from herb medicine were revealed to have positive impacts on gut microbiota and therefore could be used for the prevention or treatment of lipid metabolic disorders (Yu et al, 2018;Zhang et al, 2019b). For example, it is recently reported that the therapeutic effect of ganoderma lucidum against HFD-inducing obesity is actually working through the compositional regulation of gut microbiota (Chang et al, 2015;Chang et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Traditional Chinese Medicine Formula Kang Shuai Lao Pian Improves Obesity, Gut Dysbiosis, and Fecal Metabolic Disorders in High-Fat Diet-Fed Mice

Shouliang

Wang

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Traditional Chinese Medicine Formula Kang Shuai Lao Pian Improves Obesity, Gut Dysbiosis, and Fecal Metabolic Disorders in High-Fat Diet-Fed Mice

Shouliang

Wang

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

“…In recent years, the potential application of HMs in aquatic animals and rat models has been increasingly explored. A recent study showed that Yu-Ping-Feng (Jade screen) powder (Chinese parsnip root, Astragalus membranaceus and Atractylodes macrocephala Koidz ) can regulate the intestinal microbiota of fish (Wu et al 2018 ), the combination of Gancao-Gansui impacted the gut microbiota diversity of the rat (Yu et al 2018 ), and Salvia miltiorrhiza Bge. modulated the microbiota imbalance in diabetic mice (Gu et al 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Astragalus affects fecal microbial composition of young hens as determined by 16S rRNA sequencing

et al. 2018

View full text Add to dashboard Cite

The gut microbiota play important roles in the degradation of chemical compounds of herbal medicines (HMs). However, little information regarding the interplay between HMs and the gut microbiota is available. Thus, the aim of this study was to investigate the composition of the fecal microbiota of young (age, 11 weeks) hens fed a conventional diet containing a crude Astragalus (0.5%) additive for 21 days (group A) vs. controls (group B) that were fed only conventional feed. The fecal contents of 14-week-old hens were collected for DNA extraction, and then the V3 and V4 hyper-variable regions of the 16S rRNA gene were amplified and analyzed using high-throughput sequencing technology. A distinctive difference in microbial diversity was observed between the two groups. The microbial composition of hens fed a diet supplemented with Astragalus was greater than that of the control group. At the genus level, Lactobacillus was more abundant in group A than group B (p < 0.05). Importantly, this study is the first to report the observation of a novel Romboutsia sp. in the feces of hens. However, Romboutsia was less abundant in group A than group B (17.94 vs. 33.98%, respectively, p < 0.05). The microbial community differed significantly between the two groups at the genus level, suggesting that Astragalus modulates the composition of the fecal microbiota. Based on these differences, these findings provide fresh insights into the application of Astragalus in the poultry industry, as well as a better understanding of the interplay between HMs and the gut microbiota.

show abstract

“…Recently, mounting evidence demonstrated that TCM modulation of gut microbiota structure could be one of the mechanisms by which TCM relieves disease (Tong et al, 2018;Yu et al, 2018). When orally administered, TCM ingredients, such as polysaccharides, alkaloids and organic acids, were proven to be prebiotics which could induce changes in the gut microbiota favorable for host health (Xu et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Simiao Decoction Alleviates Gouty Arthritis by Modulating Proinflammatory Cytokines and the Gut Ecosystem

et al. 2020

View full text Add to dashboard Cite

Simiao decoction, a classical traditional Chinese medicine (TCM) formula, has been widely used for thousands of years due to its safety and efficiency in treating gouty arthritis. Utilizing serum proinflammatory cytokines and gut ecosystems, this study elucidated the mechanisms of alleviating gouty arthritis by Simiao decoction. Simiao decoction (4.0, 8.0, and 16.0 g/kg) was orally administered to gouty arthritis mice and febuxostat was given as a positive control. The spleen, kidney, and liver indexes indicated that Simiao decoction was safe for the treatment of gouty arthritis in C57BL/6 mice. Besides, our study demonstrated that Simiao decoction was effective for reducing the level of serum uric acid and decreasing MPO, XOD, and ADA activity, as well as alleviating gouty-related symptoms, such as foot swelling and pain. Moreover, Simiao decoction could also reduce some specific serum proinflammatory cytokines including IL-1b, IL-9, IFN-g, MIP-1a and MIP-1b. We then surveyed the effects of Simiao decoction on the gut ecosystems in a systematic manner by combining network pharmacology, ELISA, western blot, and illumina sequencing. In the murine of model of gouty arthritis, Simiao decoction could suppress NLRP3 inflammasomes expression, reduce gut apoptosis through modulating TNF-a, Caspase 8, and AIFM1 protein expressions, affect lipid metabolism by regulating APOB, LPL, PPARa protein expressions and restore gut microbiota via reducing potential pathogens. Overall, these findings suggested that Simiao decoction was an effective therapeutic drug for gouty arthritis and the gut ecosystem might act as a potential antiinflammatory target of Simiao decoction.

show abstract

Gancao-Gansui combination impacts gut microbiota diversity and related metabolic functions

Cited by 43 publications

References 62 publications

Traditional Chinese Medicine Formula Kang Shuai Lao Pian Improves Obesity, Gut Dysbiosis, and Fecal Metabolic Disorders in High-Fat Diet-Fed Mice

Traditional Chinese Medicine Formula Kang Shuai Lao Pian Improves Obesity, Gut Dysbiosis, and Fecal Metabolic Disorders in High-Fat Diet-Fed Mice

Astragalus affects fecal microbial composition of young hens as determined by 16S rRNA sequencing

Simiao Decoction Alleviates Gouty Arthritis by Modulating Proinflammatory Cytokines and the Gut Ecosystem

Contact Info

Product

Resources

About