Ganglion Cell Complex: The Optimal Measure for Detection of Structural Progression in the Macula

Mohammadzadeh, Vahid; Su, Erica; Rabiolo, Alessandro; Shi, Liu; Zadeh, Sepideh Heydar; Law, Simon K.; Coleman, Anne L.; Weiss, Robert E.; Nouri‐Mahdavi, Kouros

doi:10.1016/j.ajo.2021.12.009

Cited by 11 publications

(5 citation statements)

References 49 publications

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“… 25 , 26 Ganglion cell/inner plexiform layer and GCC thickness measurements display strong structure-function correlations with perimetric measures in early glaucoma. 23 , 27 , 28 Spectralis OCT provides GCL thickness as the macular layer of choice for glaucoma diagnostics based on the assumption that changes in the GCL proper would be most sensitive for the detection of early damage in glaucomatous eyes. Few studies have evaluated GCL thickness measurements for the detection of early glaucoma.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Ganglion Cell Layer and Ganglion Cell/Inner Plexiform Layer Measures for Detection of Early Glaucoma

Nezhad¹,

Mohammadzadeh²,

Martinyan³

et al. 2023

Ophthalmology Glaucoma

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Section: Discussionmentioning

confidence: 99%

Comparison of Ganglion Cell Layer and Ganglion Cell/Inner Plexiform Layer Measures for Detection of Early Glaucoma

Nezhad¹,

Mohammadzadeh²,

Martinyan³

et al. 2023

Ophthalmology Glaucoma

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“… 47 Another example, and for an OCT metric, previous studies have shown that the ganglion cell complex has better repeatability as compared with other macular summary metrics and greater discriminability for both the detection and progression of glaucomatous damage, especially in cases with moderate to advanced glaucoma. 48 – 51 Ganglion cell complex summary metrics were not calculated in this study because they were not readily available. It is likely, however, that they would show similar detection performance with the GCL and GCL+ metrics.…”

Section: Discussionmentioning

confidence: 99%

Detection of Early Glaucomatous Damage: Performance of Summary Statistics From Optical Coherence Tomography and Perimetry

Tsamis

Bruna

Leshno

et al. 2022

Trans. Vis. Sci. Tech.

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Purpose To evaluate the diagnostic performance of optical coherence tomography (OCT) and visual field (VF) summary statistics (metrics) that are available in OCT and VF reports. Methods OCT disc and macular scans and 24-2 and 10-2 VFs were obtained from 56 healthy control (HC) eyes/participants and 61 eyes/patients with 24-2 mean deviation of better than –6 dB. All metrics were obtained from OCT radial, circle, and posterior pole cube scans and 24-2 and 10-2 VFs. Their diagnostic performances were evaluated, in isolation and in combinations. For specificity, the 56 HC eyes were used. For sensitivity, 40 of the 61 patient eyes were deemed likely glaucomatous based on an automated topographic method that evaluates structure–function (S–F) agreement. Any 1 of these 40 eyes not judged as abnormal by any given metric was considered a false negative. Results All single OCT and VF metrics misclassified HCs as glaucomatous and missed likely glaucomatous eyes. The best performing single metric was the temporal inferior thickness of the 3.5-mm circle scan, with 96% specificity and 83% sensitivity. Combinations of OCT–OCT and OCT–VF metrics markedly improved specificity. A newly proposed metric that evaluates structure–structure (S–S) agreement at a hemifield level had the highest accuracy. This S–S metric had 98% specificity and 80% sensitivity. Conclusions OCT and VF metrics, single or in combinations, have only moderate sensitivity for eyes with early glaucoma. Translational Relevance OCT and VF metrics combinations evaluating S–S or S–F agreement can be highly specific, which is an important implication for clinical and research purposes.

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“…In short, our results suggest that thickening of the retinal layer and disruptions to structural homeostasis should be carefully monitored in eyes with ERM. Additionally, Mohammadzadeh et al reported that GCC is the optimal macular measurement structure for the detection of structural changes in eyes with moderate to severe glaucoma ( 25 ). Therefore, measuring the true thickness of the GCC layer is critical for monitoring glaucoma progression.…”

Section: Discussionmentioning

confidence: 99%

Effect of idiopathic epiretinal membrane on macular ganglion cell complex measurement in eyes with glaucoma

Nakakura¹,

Asaoka

Oogi³

et al. 2022

Front. Med.

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Background/objectivesCo-existing idiopathic epiretinal membrane (ERM) and glaucoma complicate the estimation of glaucoma severity via optical coherence tomography (OCT). We investigated the effect of ERM and a new associated parameter, SUKIMA (space between the ERM and retinal surface), on ganglion cell complex (GCC) thickness in eyes with glaucoma, based on a matched comparison of visual field defects.Subjects/methodsWe retrospectively recruited 41 eyes from 34 glaucoma patients with idiopathic ERM and 41 eyes from 41 glaucoma patients without ERM as controls (matched by age, axial length, and mean visual field deviation). The thicknesses of GCC layers [retinal nerve fiber layer (RNFL), ganglion cell layer + inner plexiform layer (GCIPL), and GCC (RNFL + GCIPL)] were measured with swept-source OCT. We investigated the presence of SUKIMA and its effect on GCC measurements.ResultsRNFL, GCIPL, and GCC were thicker in ERM (+) eyes than in control eyes (31.0 ± 12.3 μm vs. 22.7 ± 10.8 μm, 62.6 ± 12.2 μm vs. 53.8 ± 5.9 μm, and 91.8 ± 16.6 μm vs. 76.8 ± 13.3 μm, respectively; P < 0.01). Eyes in the ERM-associated SUKIMA (+) group had thicker GCIPL and GCC than those in the ERM-associated SUKIMA (−) and control groups (P < 0.01).ConclusionERM-associated SUKIMA affects GCC thickness and can result in underestimations of glaucoma severity. We should check for the presence of ERM using a B mode scan as well as check for the SKIMA sign.

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Ganglion Cell Complex: The Optimal Measure for Detection of Structural Progression in the Macula

Cited by 11 publications

References 49 publications

Comparison of Ganglion Cell Layer and Ganglion Cell/Inner Plexiform Layer Measures for Detection of Early Glaucoma

Comparison of Ganglion Cell Layer and Ganglion Cell/Inner Plexiform Layer Measures for Detection of Early Glaucoma

Detection of Early Glaucomatous Damage: Performance of Summary Statistics From Optical Coherence Tomography and Perimetry

Effect of idiopathic epiretinal membrane on macular ganglion cell complex measurement in eyes with glaucoma

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