Ganglion Cell-Inner Plexiform Layer, Peripapillary Retinal Nerve Fiber Layer, and Macular Thickness in Eyes with Myopic<i>β</i>-Zone Parapapillary Atrophy

Kwon, Jin Woo; Choi, Jung Sik; Kim, Jung-sub; La, Tae Yoon

doi:10.1155/2016/3746791

Cited by 4 publications

(4 citation statements)

References 49 publications

(51 reference statements)

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“…In a previous study, a tilted disc was commonly found in myopic eyes, and it was associated with a decreased RNFL thickness, particularly in myopic eyes with beta-zone parapapillary atrophy. 16 That finding was consistent with our DFT analysis.…”

Section: Discussionsupporting

confidence: 91%

Fourier analysis of circumpapillary retinal nerve fiber layer thickness in optical coherence tomography for differentiating myopia and glaucoma

Hsieh

Chang

Liu

et al. 2020

Sci Rep

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Differentiating glaucoma from myopic eye is a challenge to ophthalmologists. We try to develop a new discrete Fourier transform (DFT) model for analyzing optical coherence tomography data for the circumpapillary retinal nerve fiber layer (cpRNFL), and investigate DFT as a new diagnostic tool for glaucomatous myopic eyes. The thicknesses of 12 equidistant cpRNFL points were transformed into 6 signals in the frequency domain, ranging from 1 to 6 Hz. In all 232 eyes, generalized linear model showed that 1 Hz, 2 Hz, and 4 Hz were associated with glaucoma, high myopia, and the interaction between glaucoma and high myopia. The 3 Hz signal was associated with glaucoma and high myopia exclusively. A receiver operating characteristic curve analysis of the 3 Hz signals showed areas under the curves of 0.93 (95% CI 0.90-0.96) and 0.93 (95% CI 0.88-0.98), for diagnosing glaucoma in all subjects and in the highly myopic group, respectively. The DFT model is useful to differentiate glaucoma from non-glaucomatous change and showed potential as a diagnostic tool for glaucomatous myopic eyes. Myopia is the most common ocular problem in the world. The prevalence of myopia in Asia is higher than that in Africa, Europe, or America. 1-4 Globally, it is estimated that, between the present and the year 2050, the prevalence of myopia and high myopia will continue to grow. 5 Glaucoma is one of the leading causes of blindness. It is characterized as progressive degeneration of retinal ganglion cells and thinning of the circumpapillary retinal nerve fiber layer (cpRNFL), which is the superficial layer of retina in the human eye. In recent years, optical coherence tomography (OCT) has become an important tool for detecting early anatomical changes in the cpRNFL. OCT is currently used for disease screening and progression assessments. However, in high myopic eyes, analyses of OCT images of the cpRNFL have resulted in high false-positive error rates, which makes the diagnosis of glaucoma complicated. 6,7 Clinically, visual field examination, which reveals the patient's optic nerve function, is the gold standard test to diagnose and evaluate the progression of the glaucoma. However, it takes about half an hour to perform the test in the both eyes of a patient with a whole-process accompanied technician. It was a huge burden for patients and medical system to treat glaucoma according to the visual field test. OCT investigates the structure of the optic nerve fiber layer in the eyes by non-invasive measurement, and the test takes only few minutes. In addition to the convenience, it detects the abnormality of structure changes which is more sensitive to early pathological changes than detecting the functional abnormality. Myopia, axial elongation of the eyeball, is associated with the appearance of an optic nerve crescent, disc tilt, disc torsion, and thinning of the peripapillary RNFL in some sectors, in the absence of glaucomatous change. 8-10 Those characteristic findings, which are usually associated with glaucoma, are found in high myopic ey...

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Section: Discussionsupporting

confidence: 91%

Fourier analysis of circumpapillary retinal nerve fiber layer thickness in optical coherence tomography for differentiating myopia and glaucoma

Hsieh

Chang

Liu

et al. 2020

Sci Rep

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“…Consistent with the previous reports, we found that males have a greater macular thickness after adjusting for DFD and other covariates. It has been reported that eyes with β - PPA tend to have a thinner macular thickness 36 . In line with previous studies 26 , 36 , we found that eyes with β - PPA had a thinner macular thickness and a greater DFD.…”

Section: Discussionmentioning

confidence: 98%

“…It has been reported that eyes with β - PPA tend to have a thinner macular thickness 36 . In line with previous studies 26 , 36 , we found that eyes with β - PPA had a thinner macular thickness and a greater DFD. In the multivariable analysis, however, the presence of β - PPA was not associated with macular thickness.…”

Section: Discussionmentioning

confidence: 98%

Influence of optic disc-fovea distance on macular thickness measurements with OCT in healthy myopic eyes

Qiu

Wang

Zhang

et al. 2018

Sci Rep

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Assessment of macular thickness is important in the evaluation of various eye diseases. This study aimed to determine the influence of the optic disc-fovea distance (DFD) on macular thickness in myopic eyes. We determined the DFD and the macular thickness in 138 eyes from 138 healthy myopic subjects using the Cirrus HD-OCT. Correlation analysis and multiple linear regression were performed to determine the influence of DFD, axial length, disc area, and β-PPA on macular thickness. To further remove the confounding effect of ocular magnification on the DFD and OCT scan area, a subgroup analysis was performed in eyes with a limited axial length range (24–25 mm). DFD was significantly correlated with both regional (central, inner, and outer ETDRS subfields) and overall average macular thickness at a Bonferroni corrected P value of 0.004 (r ranging from −0.27 to −0.47), except for the temporal outer (r = −0.15, P = 0.089) and inferior outer (r = −0.22, P = 0.011) macular thickness. In the multivariable analysis, DFD was significantly associated with the average inner and outer macular thickness, the central subfield thickness, and the overall macular thickness (all P < 0.001), independent of ocular magnification and other covariates. Our findings indicate that eyes with a greater DFD have a lower macular thickness.

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“…AL appears to be significantly associated with both β -PPA [ 23 ] and decreased macular vasculature [ 24 ], and the latter two variables are affected by multiple factors. However, myopic disc changes are not always accompanied by axial elongation, which varies among individuals [ 25 ], suggesting that β -PPA also plays an important role in vasculature changes. In our study, the retinal vasculature parameters were all associated with AL and β -PPA.…”

Section: Discussionmentioning

confidence: 99%

Is the Retinal Vasculature Related to β-Peripapillary Atrophy in Nonpathological High Myopia? An Optical Coherence Tomography Angiography Study in Chinese Adults

Sun

Wang

You

et al. 2018

Journal of Ophthalmology

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Purpose The association between β-peripapillary atrophy and the retinal vasculature in nonpathological high myopia is unclear. The aim of this study is to investigate whether β-peripapillary atrophy contribute to the changes of the retinal vasculature using optical coherence tomography angiography. Methods In a cross-sectional study, one hundred and thirty eyes with nonpathological high myopia were included. β-peripapillary atrophy was analysed using Image J software based on fundus photographs. A 3.0 × 3.0 mm2 grid and a 4.5 × 4.5 mm2 grid were used to scan parafoveal and peripapillary regions using optical coherence tomography angiography, respectively. Vessel density and fractal dimensions of the retina and foveal avascular zone were analysed and quantified using en face projection images. Correlations between the vascular density, foveal avascular zone, and β-peripapillary atrophy were determined. Results Using multivariate analysis, β-peripapillary atrophy was negatively correlated with the vessel density in radial peripapillary capillaries (p=0.002) even after adjusting for other variables. This relationship was also confirmed in the macula (superficial retinal plexus: p < 0.05; deep retinal plexus: p < 0.05). The vessel densities in the nasal and inferior sectors were more strongly correlated with β-peripapillary atrophy. Conclusions There was a negative correlation between β-peripapillary atrophy and the retinal vasculature in highly myopic eyes, especially in radial peripapillary capillaries and deep retinal plexus. β-peripapillary atrophy can be visualized and is a convenient structural feature that can benefit the early diagnosis and detection of chorioretinal atrophy in high myopia.

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Ganglion Cell-Inner Plexiform Layer, Peripapillary Retinal Nerve Fiber Layer, and Macular Thickness in Eyes with Myopicβ-Zone Parapapillary Atrophy

Cited by 4 publications

References 49 publications

Fourier analysis of circumpapillary retinal nerve fiber layer thickness in optical coherence tomography for differentiating myopia and glaucoma

Fourier analysis of circumpapillary retinal nerve fiber layer thickness in optical coherence tomography for differentiating myopia and glaucoma

Influence of optic disc-fovea distance on macular thickness measurements with OCT in healthy myopic eyes

Is the Retinal Vasculature Related to β-Peripapillary Atrophy in Nonpathological High Myopia? An Optical Coherence Tomography Angiography Study in Chinese Adults

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