Ganglioneuroma in the neck masquerading as a benign mesenchymal lesion on cytology: a morphological mimic

Mahajan, Nidhi; Aggarwal, Sunita; Khurana, Nita; Jain, Shyama; Gulati, Achal

doi:10.1111/j.1365-2303.2011.00904.x

Cited by 6 publications

(2 citation statements)

References 8 publications

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“…Ganglioneuroma cytopathology has been the subject of numerous small series and single case reports. [48][49][50][51][52][53][54][55] All describe the presence of spindled schwannian stroma combined with the presence of large polygonal ganglion cells, and the absence of immature neuroblastic cells, necrosis, and inflammation in smears. The number of ganglion cells varies from rare to numerous in these reports.…”

Section: Cytologic Diagnosismentioning

confidence: 99%

Benign peripheral nerve tumors: Analysis of 89 FNA cases emphasizing diagnostic accuracy and their morphologic spectrum

Wakely

2023

Cancer Cytopathology

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Introduction Benign peripheral nerve tumors (BPNTs) are a heterogenous group of soft tissue tumors that include a variety of nerve sheath tumors, granular cell tumor (GCT), and ganglioneuroma. Only a few large studies exist on cytopathology and diagnostic accuracy using fine‐needle aspiration (FNA) biopsy for this set of neoplasms. Materials and methods Both surgical and cytopathology files were searched for cases of BPNT. FNA biopsy was performed using standard techniques. Results Eighty‐nine cases from 88 patients (male:female = 1:1; age range: 16–85 years, mean age, 51 years) met inclusion criteria. FNA sites included extremities (58, 65%), head/neck (14, 16%), deep (9, 10%), and trunk (8, 10%). Aspirates were from primary neoplasms in all but one instance. There were 65 schwannomas, seven neurofibromas, seven perineuriomas, seven GCTs, and three ganglioneuromas/neuromas. Aspirates of schwannoma, GCT, neurofibroma (NF), and perineurioma (PN) were correctly diagnosed in 86%, 100%, 29%, and 0% of cases, respectively. Five tumors (6%) were interpreted as either a specific sarcoma or suspicious for sarcoma. Remaining aspirates were classified as spindle cell neoplasm, salivary gland neoplasm, and nondiagnostic. Cytologic features for schwannoma, NF, PN, and ganglioneuroma showed spindle cell–dominant smears arranged mainly in syncytial clusters. GCT aspirates contained a population of epithelioid cells harboring coarsely granular cytoplasm and bare nuclei. Immunohistochemical (IHC) staining in 55 (62%) cases showed S‐100 expression in 95%. Conclusion FNA biopsy coupled with IHC is reliable in correctly classifying schwannoma and GCT, but less so for NF. Perineurioma can be mistaken for sarcoma.

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Section: Cytologic Diagnosismentioning

confidence: 99%

Benign peripheral nerve tumors: Analysis of 89 FNA cases emphasizing diagnostic accuracy and their morphologic spectrum

Wakely

2023

Cancer Cytopathology

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“…[ 1 2 ] The occurrence of ganglioneuroma in the neck region is limited to approximately six cases in the English literature [ Table 1 ]. [ 3 4 5 6 7 8 ] Herein, we describe a rare finding of a left submandibular mass presenting with a collision tumor consisting of cervical ganglioneuroma and metastatic tumor from the primary gingival undifferentiated carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Cervical ganglioneuroma in collision with a metastatic undifferentiated carcinoma

Jabbour¹,

Zaatari²,

Salem³

et al. 2015

J Oral Maxillofac Pathol

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Cervical ganglioneuromas are extremely rare with approximately six case reports. The current report highlights a unique collision tumor between a cervical ganglioneuroma and a metastatic undifferentiated carcinoma arising from a primary gingival mass. A 53-year-old male presented with a 2 cm left gingival mass that was excised and treated with systemic chemotherapy. Consequently, 9 months later, he developed a 3.2 cm left submandibular mass followed by recurrence of the left gingival mass. From the clinicopathologic perspective, this had to be separated from the differentials: ganglioneuroblastoma or metastatic involvement of a lymph node from primary gingival undifferentiated carcinoma.

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A case of cervical ganglioneuroma incidentally detected during surgery for oral cancer

Tanaka

Sasaguri

Yada

et al. 2023

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathol

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Ganglioneuroma in the neck masquerading as a benign mesenchymal lesion on cytology: a morphological mimic

Cited by 6 publications

References 8 publications

Benign peripheral nerve tumors: Analysis of 89 FNA cases emphasizing diagnostic accuracy and their morphologic spectrum

Benign peripheral nerve tumors: Analysis of 89 FNA cases emphasizing diagnostic accuracy and their morphologic spectrum

Cervical ganglioneuroma in collision with a metastatic undifferentiated carcinoma

A case of cervical ganglioneuroma incidentally detected during surgery for oral cancer

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